CCL1 (C-C motif chemokine ligand 1)
- symbol:
- CCL1
- locus group:
- protein-coding gene
- location:
- 17q12
- gene_family:
- Chemokine ligands|Endogenous ligands
- alias symbol:
- I-309|TCA3|P500|SISe
- alias name:
- inflammatory cytokine I-309|T lymp…
- entrez id:
- 6346
- ensembl gene id:
- ENSG00000108702
- ucsc gene id:
- uc002hid.3
- refseq accession:
- NM_002981
- hgnc_id:
- HGNC:10609
- approved reserved:
- 1990-07-05
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]
此抗微生物基因的聚集在17号染色??体的q臂上趋化因子构成涉及免疫调节和炎症过程的分泌蛋白的超家族几个趋化因子的基因之一。该超家族分为基于成熟的肽的N末端半胱氨酸残基的排列四个亚科。该趋化因子，所述CC亚家族的成员，是由活化的T细胞，并显示趋化活性单核细胞，但不为嗜中性粒细胞分泌的。它结合趋化因子（C-C基序）受体8. [由RefSeq的，2014年9月提供]
基因本体信息
CCL1基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
CCL1基因的本体（GO）信息：
| 名称 |
|---|
| 4060 Cytokine-cytokine receptor interaction [PATH:hsa04060] |
| 4062 Chemokine signaling pathway [PATH:hsa04062] |
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Glomerulonephritis | 0.2 | 2 | 0 | CTD_human_RGD |
| Pulmonary Hypertension | 0.12 | 1 | 0 | CTD_human |
| Nephritis, Interstitial | 0.12 | 1 | 0 | CTD_human |
| Experimental Autoimmune Encephalomyelitis | 0.080271442 | 2 | 0 | BeFree_RGD |
| Nephrosis | 0.08 | 0 | 0 | RGD |
| Asthma | 0.008001298 | 5 | 0 | BeFree_GAD_LHGDN |
| Endometriosis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Chronic Obstructive Airway Disease | 0.002909916 | 2 | 0 | BeFree_GAD |
| Inflammation | 0.00272435 | 1 | 0 | LHGDN |
| Tuberculosis | 0.00272435 | 1 | 0 | LHGDN |
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