CASP3基因详情-基因数据库-基因云馆

登录系统

CASP3 (caspase 3)

symbol:: CASP3
locus group:: protein-coding gene
location:: 4q35.1
gene_family:: Caspases
alias symbol:: CPP32|CPP32B|Yama|apopain
alias name:: None
entrez id:: 836
ensembl gene id:: ENSG00000164305
ucsc gene id:: uc003iwi.4
refseq accession:: NM_004346
hgnc_id:: HGNC:1504
approved reserved:: 1996-07-22

4q35.1

CASP3（半胱天冬酶3，caspase-3）是一种关键的凋亡执行蛋白酶，属于半胱天冬酶（caspase）家族。该家族成员均含有半胱氨酸活性位点，并在天冬氨酸残基后切割底物蛋白，参与细胞凋亡（程序性细胞死亡）和炎症反应。CASP3作为凋亡的“刽子手”，其功能是将细胞推入不可逆的凋亡阶段。它通常以无活性的酶原形式存在，被上游caspase（如CASP8、CASP9）激活后，切割多种关键底物（如PARP、核纤层蛋白），导致DNA断裂、细胞皱缩和凋亡小体形成。CASP3的主要作用位点包括细胞质和细胞核。突变可能导致其功能丧失或异常激活，前者可能抑制凋亡（与癌症发生相关），后者可能引发过度凋亡（如神经退行性疾病）。该基因与阿尔茨海默病、帕金森病等神经疾病密切相关，也参与肿瘤耐药性调控。CASP3过表达会加速凋亡，导致组织损伤（如心肌梗死后的细胞死亡）；而表达不足则可能使癌细胞逃避凋亡，促进肿瘤发展。CASP3还通过调控其他凋亡相关基因（如BCL-2家族）发挥作用。其家族成员（如CASP1、CASP8）共享保守的C末端催化结构域，但功能分化：CASP1主要参与炎症，CASP8侧重死亡受体介导的凋亡起始。

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]

这个基因编码的蛋白质是半胱氨酸天冬氨酸蛋白酶（胱天蛋白酶）家族的一个成员。胱天蛋白酶的顺序激活在细胞凋亡的执行阶段发挥中心作用。胱天蛋白酶存在其中在保守天冬氨酸残基经受蛋白水解加工以产生两个亚基，大，小，即二聚化以形成活性酶作为无活性酶原。该蛋白质裂解和激活胱天蛋白酶6,7和9，以及该蛋白质本身是由胱天蛋白酶8,9和10。它是一种参与β-淀粉样4A的前体蛋白，其与神经元死亡相关的裂解的主要蛋白酶处理阿尔茨海默氏病。该基因导致两个转录变异体，其编码相同蛋白质的选择性剪接。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CASP3基因的介绍 Wikipedia数据库中对CASP3基因的介绍

CASP3基因的碱基序列：[NCBI]

Loading Gene Browser...

CASP3基因的碱基突变：仅显示部分snp

rs6948 rs8549 rs1049210 rs1049216 rs1049253 rs1405937 rs1405938 rs1405942 rs1405944 rs1830254 rs2019978 rs2310103 rs2696040 rs2696048 rs2696056 rs2696057 rs2696060

CASP3基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

AAATGGATTATCCTGAGATGGG

GACCGAGATGTCATTCCAG

AAATGGATTATCCTGAGATGGG

GACCGAGATGTCATTCCAG

AAATGGATTATCCTGAGATGGG

GACCGAGATGTCATTCCAG

AAATGGATTATCCTGAGATGGG

GACCGAGATGTCATTCCAG

AGCACCTGGTTATTATTCTTGG

ATACTGTTTCAGCATGGCAC

AGCACCTGGTTATTATTCTTGG

ATACTGTTTCAGCATGGCAC

AAATGGATTATCCTGAGATGGG

GACCGAGATGTCATTCCAG

GATGATGACATGGCGTGTC

AGAATAATAACCAGGTGCTGTG

AATGGATTATCCTGAGATGGGT

AGACCGAGATGTCATTCCAG

AATGGATTATCCTGAGATGGGT

AGACCGAGATGTCATTCCAG

转录因子

影响基因

影响类型

参考文献链接（PubMed）

ING1

CASP3

Activation

15662138

ING4

CASP3

Activation

19895734

NFKB1

CASP3

Unknown

20056115

PHF10

CASP3

Unknown

20530714

PML

CASP3

Activation

16253165

RELA

CASP3

Unknown

20056115

RUNX3

CASP3

Activation

15930301; 19290488

SIM2

CASP3

Activation

21729534

SP1

CASP3

Unknown

11773055

TP53

CASP3

Unknown

21859835

CASP3基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

CASP3基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0004197

A0A087WU32 (UniProtKB)

IEA

GO:0005737

A0A087WU32 (UniProtKB)

IEA

GO:0006508

A0A087WU32 (UniProtKB)

IEA

GO:0006915

A0A087WU32 (UniProtKB)

IEA

GO:0004197

A8MVM1 (UniProtKB)

IEA

GO:0005737

A8MVM1 (UniProtKB)

IEA

GO:0006508

A8MVM1 (UniProtKB)

IEA

GO:0006915

A8MVM1 (UniProtKB)

IEA

GO:0004197

C9JXR7 (UniProtKB)

IEA

GO:0005737

C9JXR7 (UniProtKB)

IEA

GO:0006508

C9JXR7 (UniProtKB)

IEA

GO:0006915

C9JXR7 (UniProtKB)

IEA

GO:0001666

P42574 (UniProtKB)

IEA

GO:0001782

P42574 (UniProtKB)

IEA

GO:0002020

P42574 (UniProtKB)

IEA

GO:0004190

P42574 (UniProtKB)

EXP

GO:0004197

P42574 (UniProtKB)

IDA

GO:0004197

P42574 (UniProtKB)

IDA

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004197

P42574 (UniProtKB)

TAS

GO:0004861

P42574 (UniProtKB)

IEA

GO:0005123

P42574 (UniProtKB)

IEA

GO:0005515

P42574 (UniProtKB)

IPI

GO:0005515

P42574 (UniProtKB)

IPI

GO:0005515

P42574 (UniProtKB)

IPI

GO:0005515

P42574 (UniProtKB)

IPI

GO:0005515

P42574 (UniProtKB)

IPI

GO:0005515

P42574 (UniProtKB)

IPI

GO:0005515

P42574 (UniProtKB)

IPI

GO:0005515

P42574 (UniProtKB)

IPI

GO:0005515

P42574 (UniProtKB)

IPI

GO:0005515

P42574 (UniProtKB)

IPI

GO:0005515

P42574 (UniProtKB)

IPI

GO:0005515

P42574 (UniProtKB)

IPI

GO:0005634

P42574 (UniProtKB)

IDA

GO:0005654

P42574 (UniProtKB)

TAS

GO:0005654

P42574 (UniProtKB)

TAS

GO:0005654

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

IDA

GO:0005829

P42574 (UniProtKB)

IDA

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005829

P42574 (UniProtKB)

TAS

GO:0005886

P42574 (UniProtKB)

TAS

GO:0005886

P42574 (UniProtKB)

TAS

GO:0005886

P42574 (UniProtKB)

TAS

GO:0005886

P42574 (UniProtKB)

TAS

GO:0006309

P42574 (UniProtKB)

TAS

GO:0006508

P42574 (UniProtKB)

IDA

GO:0006915

P42574 (UniProtKB)

TAS

GO:0006919

P42574 (UniProtKB)

TAS

GO:0006921

P42574 (UniProtKB)

TAS

GO:0006974

P42574 (UniProtKB)

IEA

GO:0007507

P42574 (UniProtKB)

IEA

GO:0007605

P42574 (UniProtKB)

IEA

GO:0007611

P42574 (UniProtKB)

IEA

GO:0008233

P42574 (UniProtKB)

IDA

GO:0008233

P42574 (UniProtKB)

IDA

GO:0008635

P42574 (UniProtKB)

TAS

GO:0008656

P42574 (UniProtKB)

TAS

GO:0009411

P42574 (UniProtKB)

IEA

GO:0009749

P42574 (UniProtKB)

IEA

GO:0010165

P42574 (UniProtKB)

IEA

GO:0016005

P42574 (UniProtKB)

IEA

GO:0016241

P42574 (UniProtKB)

TAS

GO:0021766

P42574 (UniProtKB)

IEA

GO:0030182

P42574 (UniProtKB)

IBA

GO:0030216

P42574 (UniProtKB)

IBA

GO:0030218

P42574 (UniProtKB)

IDA

GO:0030218

P42574 (UniProtKB)

TAS

GO:0030220

P42574 (UniProtKB)

TAS

GO:0030889

P42574 (UniProtKB)

IEA

GO:0031264

P42574 (UniProtKB)

IEA

GO:0032025

P42574 (UniProtKB)

IEA

GO:0032355

P42574 (UniProtKB)

IEA

GO:0032403

P42574 (UniProtKB)

IEA

GO:0032496

P42574 (UniProtKB)

IEA

GO:0034349

P42574 (UniProtKB)

IEA

GO:0034349

P42574 (UniProtKB)

IEA

GO:0034612

P42574 (UniProtKB)

TAS

GO:0035094

P42574 (UniProtKB)

IEA

GO:0035329

P42574 (UniProtKB)

TAS

GO:0042060

P42574 (UniProtKB)

IEA

GO:0042493

P42574 (UniProtKB)

IEA

GO:0042542

P42574 (UniProtKB)

IEA

GO:0043029

P42574 (UniProtKB)

IEA

GO:0043066

P42574 (UniProtKB)

IGI

GO:0043200

P42574 (UniProtKB)

IEA

GO:0043525

P42574 (UniProtKB)

IEA

GO:0045121

P42574 (UniProtKB)

IEA

GO:0045165

P42574 (UniProtKB)

IEA

GO:0045736

P42574 (UniProtKB)

IEA

GO:0046007

P42574 (UniProtKB)

IEA

GO:0046677

P42574 (UniProtKB)

IEA

GO:0048011

P42574 (UniProtKB)

IDA

GO:0051384

P42574 (UniProtKB)

IEA

GO:0051402

P42574 (UniProtKB)

IEA

GO:0071407

P42574 (UniProtKB)

IEA

GO:0097153

P42574 (UniProtKB)

IMP

GO:0097153

P42574 (UniProtKB)

IDA

GO:0097190

P42574 (UniProtKB)

TAS

GO:0097192

P42574 (UniProtKB)

TAS

GO:0097194

P42574 (UniProtKB)

IMP

GO:0097194

P42574 (UniProtKB)

IDA

GO:0097200

P42574 (UniProtKB)

IMP

可能调控 CASP3基因的相关microRNA：

hsa-miR-128 hsa-miR-221 hsa-miR-26b hsa-miR-375 hsa-let-7e hsa-let-7e* hsa-miR-126 hsa-miR-126* hsa-miR-16 hsa-miR-181a

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
4010 MAPK signaling pathway [PATH:hsa04010]
4668 TNF signaling pathway [PATH:hsa04668]
4210 Apoptosis [PATH:hsa04210]
4115 p53 signaling pathway [PATH:hsa04115]
4650 Natural killer cell mediated cytotoxicity [PATH:hsa04650]
4726 Serotonergic synapse [PATH:hsa04726]
5200 Pathways in cancer [PATH:hsa05200]
5206 MicroRNAs in cancer [PATH:hsa05206]
5205 Proteoglycans in cancer [PATH:hsa05205]
5203 Viral carcinogenesis [PATH:hsa05203]
5210 Colorectal cancer [PATH:hsa05210]
5010 Alzheimer's disease [PATH:hsa05010]
5012 Parkinson's disease [PATH:hsa05012]
5014 Amyotrophic lateral sclerosis (ALS) [PATH:hsa05014]
5016 Huntington's disease [PATH:hsa05016]
5416 Viral myocarditis [PATH:hsa05416]
4932 Non-alcoholic fatty liver disease (NAFLD) [PATH:hsa04932]
5120 Epithelial cell signaling in Helicobacter pylori infection [PATH:hsa05120]
5133 Pertussis [PATH:hsa05133]
5134 Legionellosis [PATH:hsa05134]
5152 Tuberculosis [PATH:hsa05152]
5161 Hepatitis B [PATH:hsa05161]
5168 Herpes simplex infection [PATH:hsa05168]
5146 Amoebiasis [PATH:hsa05146]
5145 Toxoplasmosis [PATH:hsa05145]

名称
Activation of caspases through apoptosome-mediated cleavage
Activation of DNA fragmentation factor
Apoptosis
Apoptosis induced DNA fragmentation
Apoptotic cleavage of cell adhesion proteins
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Apoptotic factor-mediated response
Caspase activation via extrinsic apoptotic signalig pathway
Caspase-mediated cleavage of cytoskeletal proteins
Cell death signalling via NRAGE, NRIF and NADE
Cytochrome c-mediated apoptotic response
Degradation of the extracellular matrix
Extracellular matrix organization
Intrinsic Pathway for Apoptosis
Ligand-independent caspase activation via DCC
NADE modulates death signalling
p75 NTR receptor-mediated signalling
Programmed Cell Death
Signal Transduction
Signaling by Hippo
Signalling by NGF
SMAC binds to IAPs
SMAC-mediated apoptotic response
SMAC-mediated dissociation of IAP:caspase complexes
Stimulation of the cell death response by PAK-2p34

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Diabetes Mellitus, Experimental	0.2	2	0	CTD_human_RGD
Diabetic Retinopathy	0.2	2	0	CTD_human_RGD
Reperfusion Injury	0.2	2	0	CTD_human_RGD
Diabetic Neuropathies	0.2	2	0	CTD_human_RGD
Status Epilepticus	0.2	3	0	CTD_human_RGD
Myocardial Reperfusion Injury	0.2	2	0	CTD_human_RGD
Alzheimer's Disease	0.128163119	13	0	BeFree_CTD_human_LHGDN
Brain Ischemia	0.12272435	3	0	CTD_human_LHGDN
Ulcerative Colitis	0.120271442	2	0	BeFree_CTD_human
Mycoplasma Infections	0.120271442	1	0	BeFree_CTD_human

联系方式

山东省济南市章丘区文博路2号齐鲁师范学院 genelibs生信实验室

山东省济南市高新区舜华路750号大学科技园北区F座4单元2楼

电话： 0531-88819269

E-mail: product@genelibs.com

微信公众号

关注微信订阅号，实时查看信息，关注医学生物学动态。

更新于2天前

CASP3 (caspase 3)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

联系方式

微信公众号