CALCA (calcitonin related polypeptide alpha)

基因基本信息

基因基本信息

symbol:
CALCA
locus group:
protein-coding gene
location:
11p15.2
gene_family:
Endogenous ligands
alias symbol:
CGRP|CGRP-alpha
alias name:
calcitonin
entrez id:
796
ensembl gene id:
ENSG00000110680
ucsc gene id:
uc001mlt.2
refseq accession:
NM_001741
hgnc_id:
HGNC:1437
approved reserved:
1986-01-01

基因染色体位置

基因染色体位置

11p15.2
基因染色体位置图

基因简述

基因简述

CALCA基因（Calcitonin-related polypeptide alpha，降钙素相关多肽α）编码降钙素（Calcitonin）和降钙素基因相关肽（CGRP，Calcitonin Gene-Related Peptide），这两种产物通过选择性RNA剪接产生，具有不同的生物学功能。降钙素主要由甲状腺C细胞分泌，参与钙磷代谢调节，通过抑制破骨细胞活性降低血钙水平；而CGRP是一种强效血管舒张神经肽，广泛分布于中枢和周围神经系统，参与疼痛传递、炎症反应及心血管调节（如扩张血管、调节血压）。CALCA基因突变可能导致降钙素或CGRP功能异常，例如降钙素分泌异常与甲状腺髓样癌（MTC）相关，而CGRP失调与偏头痛、高血压和心力衰竭等疾病密切相关。若CALCA过表达，可能因CGRP过量引发血管过度舒张（如偏头痛发作），或降钙素异常升高导致低钙血症；表达降低则可能影响骨代谢（如骨质疏松）或加剧心血管疾病风险。该基因属于降钙素基因家族（Calcitonin gene family），家族成员还包括CALCB（编码CGRP-β）等，共性为编码多肽激素或神经肽，参与代谢、神经信号传导和心血管调控。目前针对CGRP的抗体药物（如erenumab）已用于偏头痛治疗，体现了该基因的临床价值。

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

该基??因编码的肽类激素降钙素，降钙素基因相关肽和由该基因转录的组织特异性选择性RNA剪接和无活性的前体蛋白的裂解钙抑肽。降钙素参与钙调节，其作用是调节磷代谢。降钙素基因相关肽用作血管扩张剂和作为同时钙抑肽抗微生物肽是钙降肽??。多个转录变异体的编码不同亚型也发现了这种基因。[由RefSeq的，2014年8月提供]

OMIM数据库中对CALCA基因的介绍     Wikipedia数据库中对CALCA基因的介绍

基因序列

基因序列

CALCA基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

CALCA基因的碱基突变：           仅显示部分snp
rs2956       rs5237       rs5238       rs5239       rs5240       rs5241       rs5242       rs5243       rs924099       rs1010042       rs1553005       rs2071411       rs2644688       rs2644689       rs2644690       rs3758761       rs3781718      

基因表达

基因表达

CALCA基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CAACAAGTTTCACACGTTCC
58
GCAATGATTATGAGGGCGA
58
ACTGGTGCAGGACTATGTG
59
TTCTGGGCAATGATTCTGGA
59
CTATGTGCAGATGAAGGCC
58
TACTCAGATTACCGCACCG
59
ACTGGTGCAGGACTATGTG
59
TCTGGGCAATGATTCTGGAG
59
TATGTGCAGATGAAGGCCA
59
GTACTCAGATTACCGCACC
57
ACAAGTTTCACACGTTCCC
58
GGCAATGATTATGAGGGCG
59
ACTGGTGCAGGACTATGTG
59
TCTGGGCAATGATTCTGGA
58
TATGTGCAGATGAAGGCCA
59
TACTCAGATTACCGCACCG
59
ACAAGTTTCACACGTTCCC
58
GCAATGATTATGAGGGCGA
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

CALCA基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

CALCA基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0001984
P01258 (UniProtKB)
IEA
GO:0002027
P01258 (UniProtKB)
IEA
GO:0002548
P01258 (UniProtKB)
IDA
GO:0005179
P01258 (UniProtKB)
IEA
GO:0005515
P01258 (UniProtKB)
IPI
GO:0005515
P01258 (UniProtKB)
IPI
GO:0005576
P01258 (UniProtKB)
TAS
GO:0005576
P01258 (UniProtKB)
TAS
GO:0005576
P01258 (UniProtKB)
TAS
GO:0005576
P01258 (UniProtKB)
TAS
GO:0005576
P01258 (UniProtKB)
TAS
GO:0005576
P01258 (UniProtKB)
TAS
GO:0005615
P01258 (UniProtKB)
IDA
GO:0005634
P01258 (UniProtKB)
IEA
GO:0005737
P01258 (UniProtKB)
IEA
GO:0006954
P01258 (UniProtKB)
IEA
GO:0006954
P01258 (UniProtKB)
IEA
GO:0007189
P01258 (UniProtKB)
IEA
GO:0007190
P01258 (UniProtKB)
IEA
GO:0007204
P01258 (UniProtKB)
IDA
GO:0007218
P01258 (UniProtKB)
IEA
GO:0007566
P01258 (UniProtKB)
IDA
GO:0007568
P01258 (UniProtKB)
IEA
GO:0007631
P01258 (UniProtKB)
IEA
GO:0009408
P01258 (UniProtKB)
IEA
GO:0030279
P01258 (UniProtKB)
IEA
GO:0031645
P01258 (UniProtKB)
IEA
GO:0031716
P01258 (UniProtKB)
IPI
GO:0031716
P01258 (UniProtKB)
IPI
GO:0031716
P01258 (UniProtKB)
IPI
GO:0032147
P01258 (UniProtKB)
IDA
GO:0042802
P01258 (UniProtKB)
IPI
GO:0043025
P01258 (UniProtKB)
IEA
GO:0043025
P01258 (UniProtKB)
IEA
GO:0043195
P01258 (UniProtKB)
IEA
GO:0044267
P01258 (UniProtKB)
TAS
GO:0045762
P01258 (UniProtKB)
IDA
GO:0045762
P01258 (UniProtKB)
IDA
GO:0045778
P01258 (UniProtKB)
IEA
GO:0045779
P01258 (UniProtKB)
IDA
GO:0045892
P01258 (UniProtKB)
IDA
GO:0045986
P01258 (UniProtKB)
IEA
GO:0045986
P01258 (UniProtKB)
IEA
GO:0048265
P01258 (UniProtKB)
IEA
GO:0050965
P01258 (UniProtKB)
IEA
GO:0051482
P01258 (UniProtKB)
IDA
GO:0071356
P01258 (UniProtKB)
IEA
GO:1990090
P01258 (UniProtKB)
IEA
GO:1990090
P01258 (UniProtKB)
IEA
GO:0001878
P06881 (UniProtKB)
IDA
GO:0001935
P06881 (UniProtKB)
IDA
GO:0001944
P06881 (UniProtKB)
IDA
GO:0001976
P06881 (UniProtKB)
IDA
GO:0002031
P06881 (UniProtKB)
IDA
GO:0005102
P06881 (UniProtKB)
IDA
GO:0005179
P06881 (UniProtKB)
IEA
GO:0005515
P06881 (UniProtKB)
IPI
GO:0005515
P06881 (UniProtKB)
IPI
GO:0005515
P06881 (UniProtKB)
IPI
GO:0005515
P06881 (UniProtKB)
IPI
GO:0005576
P06881 (UniProtKB)
TAS
GO:0005576
P06881 (UniProtKB)
TAS
GO:0005576
P06881 (UniProtKB)
TAS
GO:0005576
P06881 (UniProtKB)
TAS
GO:0005615
P06881 (UniProtKB)
IDA
GO:0005737
P06881 (UniProtKB)
IDA
GO:0006468
P06881 (UniProtKB)
IDA
GO:0007159
P06881 (UniProtKB)
IDA
GO:0007190
P06881 (UniProtKB)
IDA
GO:0007190
P06881 (UniProtKB)
IDA
GO:0007267
P06881 (UniProtKB)
TAS
GO:0008217
P06881 (UniProtKB)
NAS
GO:0010523
P06881 (UniProtKB)
IDA
GO:0019731
P06881 (UniProtKB)
IDA
GO:0019732
P06881 (UniProtKB)
IDA
GO:0030819
P06881 (UniProtKB)
IDA
GO:0030819
P06881 (UniProtKB)
IDA
GO:0031623
P06881 (UniProtKB)
IDA
GO:0032403
P06881 (UniProtKB)
IDA
GO:0032730
P06881 (UniProtKB)
IDA
GO:0032757
P06881 (UniProtKB)
IDA
GO:0043542
P06881 (UniProtKB)
IDA
GO:0045087
P06881 (UniProtKB)
IDA
GO:0045651
P06881 (UniProtKB)
IDA
GO:0045671
P06881 (UniProtKB)
IDA
GO:0045776
P06881 (UniProtKB)
IDA
GO:0045779
P06881 (UniProtKB)
IDA
GO:0045909
P06881 (UniProtKB)
IDA
GO:0050829
P06881 (UniProtKB)
IDA
GO:0050830
P06881 (UniProtKB)
IDA
GO:0051480
P06881 (UniProtKB)
IDA
GO:0051482
P06881 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 CALCA基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Hyperalgesia 0.2 4 0 CTD_human_RGD
Inflammation 0.2 2 0 CTD_human_RGD
Migraine Disorders 0.133787454 25 0 BeFree_CTD_human_GAD_LHGDN
Hypertensive disease 0.128815624 9 0 BeFree_CTD_human_GAD_LHGDN
Prostatic Neoplasms 0.126263026 5 0 BeFree_CTD_human_LHGDN
Degenerative polyarthritis 0.122909916 3 0 BeFree_CTD_human_GAD
Hypercalcemia 0.121357209 7 0 BeFree_CTD_human
Pulmonary Hypertension 0.120542884 3 0 BeFree_CTD_human
Arthritis, Experimental 0.12 1 0 CTD_human
Intellectual Disability 0.12 1 0 CTD_human

基因相关服务

基因相关服务

联系方式

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