BRMS1 (BRMS1 transcriptional repressor and anoikis regulator)
- symbol:
- BRMS1
- locus group:
- protein-coding gene
- location:
- 11q13.2
- gene_family:
- alias symbol:
- DKFZP564A063
- alias name:
- None
- entrez id:
- 25855
- ensembl gene id:
- ENSG00000174744
- ucsc gene id:
- uc001ohp.2
- refseq accession:
- NM_015399
- hgnc_id:
- HGNC:17262
- approved reserved:
- 2003-12-02
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
该基因降低的转移潜能，但不是瘤性人乳腺癌和黑素瘤细胞系的。由该基因编码的蛋白定位主要是细胞核和为mSin3a家庭组蛋白脱乙酰复合物（HDAC）的一个组件。蛋白质含有两个卷曲螺旋图案和一些不完善的亮氨酸拉链图案。两个转录剪接变异体导致编码不同亚型。 [由RefSeq的，2008年7月提供]
基因本体信息
BRMS1基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
BRMS1基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Neoplasm Metastasis | 0.026369588 | 59 | 0 | BeFree_LHGDN |
| Mammary Neoplasms | 0.01225461 | 9 | 0 | BeFree_LHGDN |
| Breast Carcinoma | 0.009500466 | 35 | 0 | BeFree |
| Malignant neoplasm of breast | 0.009500466 | 35 | 0 | BeFree |
| melanoma | 0.008434561 | 12 | 0 | BeFree_LHGDN |
| Lung Neoplasms | 0.005720142 | 3 | 0 | BeFree_LHGDN |
| Non-Small Cell Lung Carcinoma | 0.002171535 | 8 | 0 | BeFree |
| Tumor Progression | 0.001357209 | 5 | 0 | BeFree |
| Carcinoma breast stage IV | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000814326 | 3 | 0 | BeFree |
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