BID (BH3 interacting domain death agonist)

基因基本信息

基因基本信息

symbol:
BID
locus group:
protein-coding gene
location:
22q11.21
gene_family:
Endogenous ligands
alias symbol:
None
alias name:
None
entrez id:
637
ensembl gene id:
ENSG00000015475
ucsc gene id:
uc002znd.3
refseq accession:
NM_197966
hgnc_id:
HGNC:1050
approved reserved:
1998-04-20

基因染色体位置

基因染色体位置

22q11.21
基因染色体位置图

基因简述

基因简述

This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

None

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

BID基因的碱基突变：           仅显示部分snp
rs11538       rs25591       rs181382       rs181383       rs181384       rs181385       rs181386       rs181387       rs181388       rs181389       rs181390       rs181391       rs181392       rs181393       rs181394       rs181395       rs181396      

基因表达

基因表达

BID基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GACTGTGAGGTCAACAACG
59
TCAGAACAGCTTTGGAGGA
59
AGCCAGAAATGGGATGGAC
60
CAGCTATACAGCTGTGACCA
60
AAGTGCTGAGGAAGAAACG
58
TTTCAGAATCACTGTCGCAG
59
TCCGTGATGTCTTTCACAC
58
CAGTCCATCCCATTTCTGG
58
GACTGTTCCAGAAACAGCC
59
GAACCGTTGTTGACTCCAG
59
TCCGTGATGTCTTTCACAC
58
CAGTCCATCCCATTTCTGG
58
GACTGTGAGGTCAACAACG
59
GTCAGAACAGCTTTGGAGG
59
TCCGTGATGTCTTTCACAC
58
CAGTCCATCCCATTTCTGG
58
TCCGTGATGTCTTTCACAC
58
CAGTCCATCCCATTTCTGG
58
GACTGTGAGGTCAACAACG
59
GTCAGAACAGCTTTGGAGG
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
HIF1A
BID
Repression
15024076
ZBTB16
BID
Repression
20731660

基因本体信息

BID基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

BID基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005737
B2ZP78 (UniProtKB)
IEA
GO:0043065
B2ZP78 (UniProtKB)
IEA
GO:0001836
P55957 (UniProtKB)
IDA
GO:0005123
P55957 (UniProtKB)
TAS
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005515
P55957 (UniProtKB)
IPI
GO:0005739
P55957 (UniProtKB)
TAS
GO:0005741
P55957 (UniProtKB)
TAS
GO:0005741
P55957 (UniProtKB)
TAS
GO:0005741
P55957 (UniProtKB)
TAS
GO:0005741
P55957 (UniProtKB)
TAS
GO:0005741
P55957 (UniProtKB)
TAS
GO:0005741
P55957 (UniProtKB)
TAS
GO:0005741
P55957 (UniProtKB)
TAS
GO:0005829
P55957 (UniProtKB)
TAS
GO:0005829
P55957 (UniProtKB)
TAS
GO:0005829
P55957 (UniProtKB)
TAS
GO:0005829
P55957 (UniProtKB)
TAS
GO:0005829
P55957 (UniProtKB)
TAS
GO:0005829
P55957 (UniProtKB)
TAS
GO:0005829
P55957 (UniProtKB)
TAS
GO:0006626
P55957 (UniProtKB)
IEA
GO:0006919
P55957 (UniProtKB)
IEA
GO:0007420
P55957 (UniProtKB)
IEA
GO:0008625
P55957 (UniProtKB)
TAS
GO:0008637
P55957 (UniProtKB)
TAS
GO:0016020
P55957 (UniProtKB)
TAS
GO:0031625
P55957 (UniProtKB)
IEA
GO:0032355
P55957 (UniProtKB)
IEA
GO:0032461
P55957 (UniProtKB)
IDA
GO:0032464
P55957 (UniProtKB)
IDA
GO:0032592
P55957 (UniProtKB)
IEA
GO:0034349
P55957 (UniProtKB)
IEA
GO:0042127
P55957 (UniProtKB)
IEA
GO:0042770
P55957 (UniProtKB)
TAS
GO:0042981
P55957 (UniProtKB)
TAS
GO:0043065
P55957 (UniProtKB)
IMP
GO:0043065
P55957 (UniProtKB)
IMP
GO:0051260
P55957 (UniProtKB)
IEA
GO:0051402
P55957 (UniProtKB)
TAS
GO:0070062
P55957 (UniProtKB)
IDA
GO:0090150
P55957 (UniProtKB)
IDA
GO:0090200
P55957 (UniProtKB)
IMP
GO:0090200
P55957 (UniProtKB)
IGI
GO:0097284
P55957 (UniProtKB)
IEA
GO:0097345
P55957 (UniProtKB)
IEA
GO:1900740
P55957 (UniProtKB)
TAS
GO:1900740
P55957 (UniProtKB)
TAS
GO:1901030
P55957 (UniProtKB)
TAS
GO:1901030
P55957 (UniProtKB)
TAS
GO:2000045
P55957 (UniProtKB)
IEA
GO:2001238
P55957 (UniProtKB)
IMP
GO:2001244
P55957 (UniProtKB)
TAS

基因相关microRNA

基因相关microRNA

可能调控 BID基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Stomach Neoplasms 0.122367032 2 0 CTD_human_GAD
Liver carcinoma 0.120271442 2 0 BeFree_CTD_human
Myocardial Reperfusion Injury 0.08 1 0 RGD
Reperfusion Injury 0.08 1 0 RGD
Mammary Neoplasms 0.008173051 3 0 LHGDN
Adenocarcinoma 0.007815732 3 0 GAD_LHGDN
Malignant neoplasm of breast 0.005819831 5 5 BeFree_GAD
melanoma 0.002995792 2 1 BeFree_LHGDN
Colonic Neoplasms 0.00272435 1 0 LHGDN
Lung Neoplasms 0.00272435 1 0 LHGDN

基因相关服务

基因相关服务

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