BCL2 (BCL2 apoptosis regulator)

基因基本信息

基因基本信息

symbol:
BCL2
locus group:
protein-coding gene
location:
18q21.33
gene_family:
Protein phosphatase 1 regulatory subunits
alias symbol:
Bcl-2|PPP1R50
alias name:
protein phosphatase 1, regulatory …
entrez id:
596
ensembl gene id:
ENSG00000171791
ucsc gene id:
uc002liu.2
refseq accession:
NM_000633|NM_000657
hgnc_id:
HGNC:990
approved reserved:
2001-06-22

基因染色体位置

基因染色体位置

18q21.33
基因染色体位置图

基因简述

基因简述

BCL2（B细胞淋巴瘤2基因）属于BCL2基因家族，该家族主要调控细胞凋亡（程序性细胞死亡）过程，在维持细胞存活与死亡的平衡中起关键作用。BCL2基因编码的蛋白质是一种抗凋亡蛋白，通过抑制线粒体外膜通透性（MOMP）阻止细胞色素C的释放，从而阻断凋亡信号的传递，延长细胞存活时间。其主要作用位点在线粒体膜上，通过与促凋亡蛋白（如BAX、BAK）结合来抑制它们的活性。BCL2基因的突变可能导致其功能异常，例如在某些淋巴瘤中发现的染色体易位t(14;18)会使BCL2过表达，抑制正常凋亡过程，促进癌细胞存活，这与滤泡性淋巴瘤和慢性淋巴细胞白血病等疾病密切相关。如果BCL2过表达，会过度抑制细胞凋亡，可能导致肿瘤发生或对化疗药物产生耐药性；而降低表达则可能使细胞对凋亡信号过于敏感，导致组织损伤或加速神经退行性疾病（如阿尔茨海默病）的进程。BCL2基因家族成员通常含有BH（BCL2同源）结构域，分为抗凋亡蛋白（如BCL2、BCL-XL）和促凋亡蛋白（如BAX、BAK）两类，它们通过相互作用调控细胞命运。该家族在发育、免疫系统稳态和癌症中具有广泛影响，针对BCL2的药物（如 Venetoclax）已被开发用于治疗某些血液系统恶性肿瘤。

None

无

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

BCL2基因的碱基突变：           仅显示部分snp
rs596876       rs720321       rs720849       rs726510       rs726511       rs731014       rs744569       rs765102       rs765479       rs768058       rs899964       rs899965       rs899966       rs899967       rs899968       rs949037       rs954954      

基因表达

基因表达

BCL2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GAACAGGGTACGATAACCG
57
CTCTGCGACAGCTTATAATGG
59
GGATGCCTTTGTGGAACTG
59
GTCTTCAGAGACAGCCAGG
59
AGAACAGGGTACGATAACCG
59
TCTGCGACAGCTTATAATGGA
59
GGATGCCTTTGTGGAACTG
59
CTTCAGAGACAGCCAGGAG
59
GGATGCCTTTGTGGAACTG
59
CAGCCAGGAGAAATCAAACAG
59
AGAACAGGGTACGATAACCG
59
TCTGCGACAGCTTATAATGG
57

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
ABL1
BCL2
Repression
11753601
ATF1
BCL2
Unknown
10542244
ATF5
BCL2
Activation
21212266
ATM
BCL2
Repression
16214353
BACH2
BCL2
Unknown
18929412
CEBPA
BCL2
Repression
12970736
CREB1
BCL2
Activation
17290286
CREB1
BCL2
Unknown
10542244; 19626458
DDB2
BCL2
Repression
20013802
DEK
BCL2
Activation
17685435

基因本体信息

BCL2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

BCL2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000209
P10415 (UniProtKB)
IDA
GO:0001503
P10415 (UniProtKB)
IEA
GO:0001541
P10415 (UniProtKB)
IEA
GO:0001656
P10415 (UniProtKB)
IEA
GO:0001658
P10415 (UniProtKB)
IEA
GO:0001662
P10415 (UniProtKB)
IEA
GO:0001782
P10415 (UniProtKB)
IEA
GO:0001836
P10415 (UniProtKB)
NAS
GO:0001836
P10415 (UniProtKB)
ISS
GO:0001952
P10415 (UniProtKB)
IEA
GO:0002020
P10415 (UniProtKB)
IDA
GO:0002320
P10415 (UniProtKB)
IEA
GO:0002326
P10415 (UniProtKB)
IEA
GO:0002931
P10415 (UniProtKB)
IEA
GO:0003014
P10415 (UniProtKB)
IEA
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005515
P10415 (UniProtKB)
IPI
GO:0005634
P10415 (UniProtKB)
IDA
GO:0005634
P10415 (UniProtKB)
IDA
GO:0005737
P10415 (UniProtKB)
IDA
GO:0005737
P10415 (UniProtKB)
IDA
GO:0005739
P10415 (UniProtKB)
IDA
GO:0005739
P10415 (UniProtKB)
IDA
GO:0005741
P10415 (UniProtKB)
IDA
GO:0005741
P10415 (UniProtKB)
IDA
GO:0005741
P10415 (UniProtKB)
TAS
GO:0005741
P10415 (UniProtKB)
TAS
GO:0005741
P10415 (UniProtKB)
TAS
GO:0005741
P10415 (UniProtKB)
TAS
GO:0005783
P10415 (UniProtKB)
IDA
GO:0005789
P10415 (UniProtKB)
IEA
GO:0005829
P10415 (UniProtKB)
IEA
GO:0006470
P10415 (UniProtKB)
IEA
GO:0006582
P10415 (UniProtKB)
IEA
GO:0006808
P10415 (UniProtKB)
IEA
GO:0006915
P10415 (UniProtKB)
IDA
GO:0006915
P10415 (UniProtKB)
IDA
GO:0006959
P10415 (UniProtKB)
TAS
GO:0006974
P10415 (UniProtKB)
IMP
GO:0007015
P10415 (UniProtKB)
IEA
GO:0007409
P10415 (UniProtKB)
IEA
GO:0007565
P10415 (UniProtKB)
NAS
GO:0007569
P10415 (UniProtKB)
IEA
GO:0008134
P10415 (UniProtKB)
IEA
GO:0008584
P10415 (UniProtKB)
IEA
GO:0008625
P10415 (UniProtKB)
IDA
GO:0008630
P10415 (UniProtKB)
IBA
GO:0008631
P10415 (UniProtKB)
IEA
GO:0009314
P10415 (UniProtKB)
NAS
GO:0009636
P10415 (UniProtKB)
IDA
GO:0009636
P10415 (UniProtKB)
IDA
GO:0009791
P10415 (UniProtKB)
IEA
GO:0010039
P10415 (UniProtKB)
IDA
GO:0010224
P10415 (UniProtKB)
IEA
GO:0010332
P10415 (UniProtKB)
IEA
GO:0010468
P10415 (UniProtKB)
IEA
GO:0010507
P10415 (UniProtKB)
TAS
GO:0010523
P10415 (UniProtKB)
IEA
GO:0010559
P10415 (UniProtKB)
IEA
GO:0014031
P10415 (UniProtKB)
IEA
GO:0014042
P10415 (UniProtKB)
IEA
GO:0014911
P10415 (UniProtKB)
IEA
GO:0015267
P10415 (UniProtKB)
IDA
GO:0016020
P10415 (UniProtKB)
IDA
GO:0016049
P10415 (UniProtKB)
IEA
GO:0016248
P10415 (UniProtKB)
IDA
GO:0018105
P10415 (UniProtKB)
IEA
GO:0018107
P10415 (UniProtKB)
IEA
GO:0021747
P10415 (UniProtKB)
IEA
GO:0022612
P10415 (UniProtKB)
IEA
GO:0022898
P10415 (UniProtKB)
IDA
GO:0030279
P10415 (UniProtKB)
IEA
GO:0030307
P10415 (UniProtKB)
IDA
GO:0030308
P10415 (UniProtKB)
IEA
GO:0030318
P10415 (UniProtKB)
IEA
GO:0030336
P10415 (UniProtKB)
IEA
GO:0030890
P10415 (UniProtKB)
IMP
GO:0031069
P10415 (UniProtKB)
IEA
GO:0031103
P10415 (UniProtKB)
IEA
GO:0031625
P10415 (UniProtKB)
IPI
GO:0031647
P10415 (UniProtKB)
IEA
GO:0031965
P10415 (UniProtKB)
IDA
GO:0031965
P10415 (UniProtKB)
IDA
GO:0031965
P10415 (UniProtKB)
IDA
GO:0031965
P10415 (UniProtKB)
IDA
GO:0032469
P10415 (UniProtKB)
TAS
GO:0032835
P10415 (UniProtKB)
IEA
GO:0032848
P10415 (UniProtKB)
IDA
GO:0033033
P10415 (UniProtKB)
IEA
GO:0033077
P10415 (UniProtKB)
IEA
GO:0033138
P10415 (UniProtKB)
IEA
GO:0033689
P10415 (UniProtKB)
IEA
GO:0034097
P10415 (UniProtKB)
IDA
GO:0035094
P10415 (UniProtKB)
IDA
GO:0035265
P10415 (UniProtKB)
IEA
GO:0040018
P10415 (UniProtKB)
IEA
GO:0042100
P10415 (UniProtKB)
IDA
GO:0042149
P10415 (UniProtKB)
IEA
GO:0042493
P10415 (UniProtKB)
IMP
GO:0042493
P10415 (UniProtKB)
IDA
GO:0042542
P10415 (UniProtKB)
IEA
GO:0042802
P10415 (UniProtKB)
IPI
GO:0042802
P10415 (UniProtKB)
IPI
GO:0042803
P10415 (UniProtKB)
IPI
GO:0043029
P10415 (UniProtKB)
IEA
GO:0043066
P10415 (UniProtKB)
IDA
GO:0043066
P10415 (UniProtKB)
IDA
GO:0043066
P10415 (UniProtKB)
IDA
GO:0043066
P10415 (UniProtKB)
IDA
GO:0043066
P10415 (UniProtKB)
IMP
GO:0043066
P10415 (UniProtKB)
IMP
GO:0043066
P10415 (UniProtKB)
IDA
GO:0043066
P10415 (UniProtKB)
IDA
GO:0043066
P10415 (UniProtKB)
IMP
GO:0043066
P10415 (UniProtKB)
IDA
GO:0043066
P10415 (UniProtKB)
IDA
GO:0043066
P10415 (UniProtKB)
IDA
GO:0043066
P10415 (UniProtKB)
IDA
GO:0043066
P10415 (UniProtKB)
IGI
GO:0043085
P10415 (UniProtKB)
IEA
GO:0043209
P10415 (UniProtKB)
IEA
GO:0043375
P10415 (UniProtKB)
IEA
GO:0043496
P10415 (UniProtKB)
IDA
GO:0043497
P10415 (UniProtKB)
IDA
GO:0043524
P10415 (UniProtKB)
IDA
GO:0043565
P10415 (UniProtKB)
IDA
GO:0043583
P10415 (UniProtKB)
IEA
GO:0045069
P10415 (UniProtKB)
IEA
GO:0045636
P10415 (UniProtKB)
IEA
GO:0046671
P10415 (UniProtKB)
IEA
GO:0046902
P10415 (UniProtKB)
ISS
GO:0046930
P10415 (UniProtKB)
IDA
GO:0046982
P10415 (UniProtKB)
IPI
GO:0048041
P10415 (UniProtKB)
IEA
GO:0048536
P10415 (UniProtKB)
IEA
GO:0048538
P10415 (UniProtKB)
IEA
GO:0048546
P10415 (UniProtKB)
IEA
GO:0048599
P10415 (UniProtKB)
IEA
GO:0048743
P10415 (UniProtKB)
IEA
GO:0048753
P10415 (UniProtKB)
IEA
GO:0048873
P10415 (UniProtKB)
IEA
GO:0050853
P10415 (UniProtKB)
IMP
GO:0051384
P10415 (UniProtKB)
IEA
GO:0051402
P10415 (UniProtKB)
TAS
GO:0051434
P10415 (UniProtKB)
IPI
GO:0051434
P10415 (UniProtKB)
IPI
GO:0051607
P10415 (UniProtKB)
IDA
GO:0051721
P10415 (UniProtKB)
IEA
GO:0051881
P10415 (UniProtKB)
ISS
GO:0051902
P10415 (UniProtKB)
TAS
GO:0051924
P10415 (UniProtKB)
IDA
GO:0055085
P10415 (UniProtKB)
IEA
GO:0070059
P10415 (UniProtKB)
IDA
GO:0071310
P10415 (UniProtKB)
IEA
GO:0071456
P10415 (UniProtKB)
IEA
GO:0072593
P10415 (UniProtKB)
IEA
GO:0097192
P10415 (UniProtKB)
IEA
GO:1900740
P10415 (UniProtKB)
TAS
GO:2000134
P10415 (UniProtKB)
IEA
GO:2000378
P10415 (UniProtKB)
IEA
GO:2000811
P10415 (UniProtKB)
IMP
GO:2001234
P10415 (UniProtKB)
IMP
GO:2001240
P10415 (UniProtKB)
IGI
GO:2001243
P10415 (UniProtKB)
IDA
GO:2001244
P10415 (UniProtKB)
TAS

基因相关microRNA

基因相关microRNA

可能调控 BCL2基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Lymphoma, Follicular 0.343804516 358 5 BeFree_CTD_human_GAD_LHGDN_ORPHANET
Chronic Lymphocytic Leukemia 0.297966465 170 2 BeFree_CTD_human_GAD_GWASCAT_LHGDN
Colonic Neoplasms 0.209801702 12 0 BeFree_CTD_human_LHGDN_RGD
Reperfusion Injury 0.2054487 5 0 CTD_human_LHGDN_RGD
Alzheimer's Disease 0.203724241 9 0 BeFree_CTD_human_GAD_RGD
Diabetes Mellitus, Non-Insulin-Dependent 0.200542884 4 0 BeFree_CTD_human_RGD
Hypertensive disease 0.200271442 3 0 BeFree_CTD_human_RGD
Polycystic Ovary Syndrome 0.200271442 2 0 BeFree_CTD_human_RGD
Diabetes Mellitus, Experimental 0.2 4 0 CTD_human_RGD
Erectile dysfunction 0.2 2 0 CTD_human_RGD

基因相关服务

基因相关服务

联系方式

山东省济南市 高新区 崇华路359号 三庆世纪财富中心C1115室

电话： 0531-88819269

E-mail: product@genelibs.com

微信公众号

关注微信订阅号，实时查看信息，关注医学生物学动态。

版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2