BCAR4 (breast cancer anti-estrogen resistance 4)
- symbol:
- BCAR4
- locus group:
- non-coding RNA
- location:
- 16p13.13
- gene_family:
- alias symbol:
- None
- alias name:
- None
- entrez id:
- 400500
- ensembl gene id:
- ENSG00000262117
- ucsc gene id:
- uc059qxb.1
- refseq accession:
- NR_024049
- hgnc_id:
- HGNC:22170
- approved reserved:
- 2006-05-09
This gene produces a spliced long non-coding RNA (lncRNA) that has been implicated in breast cancer metastasis. It was originally identified in a screen for genes responsible for the development of resistance to anti-estrogens in breast cancer cells. It is thought that release of CCL21 enables this lncRNA to bind to the SNIP1 and PNUTS transcription factors, thereby activating a non-canonical GLI-dependent hedgehog signaling pathway that promotes cancer cell migration and invasion. A similar gene in cow expresses a protein in mature oocytes and preimplantation embryos. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2015]
该基因产生已在乳腺癌转移被牵连拼接长链非编码RNA（lncRNA）。它在对负责抗性的发展，以在乳腺癌细胞中的抗雌激素基因的屏幕最初被鉴定。据认为，CCL21的释放使此lncRNA绑定到SNIP1和PNUTS转录因子，从而激活一个非经典的GLI依赖性hedgehog信号传导途径，促进癌细胞的迁移和侵袭。在奶牛类似的基因表达成熟的卵母细胞和植入前胚胎的蛋白质。可变剪接转录物变体也已确定。 [由RefSeq的，2015年4月提供]
基因本体信息
BCAR4基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
BCAR4基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Mammary Neoplasms | 0.123267234 | 3 | 0 | BeFree_CTD_human_LHGDN |
| Breast Carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Malignant neoplasm of breast | 0.001357209 | 5 | 0 | BeFree |
| Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
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