BCAR3 (BCAR3 adaptor protein, NSP family member)
- symbol:
- BCAR3
- locus group:
- protein-coding gene
- location:
- 1p22.1
- gene_family:
- SH2 domain containing
- alias symbol:
- NSP2|SH2D3B|AND-34|MIG7
- alias name:
- migration inducting gene-7
- entrez id:
- 8412
- ensembl gene id:
- ENSG00000137936
- ucsc gene id:
- uc001dqb.5
- refseq accession:
- NM_001261408
- hgnc_id:
- HGNC:973
- approved reserved:
- 1999-04-29
Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
乳腺肿瘤最初依赖于雌激素对生长和进展，并且可以通过抗雌激素诸如他莫昔芬被抑制。然而，乳腺癌进展成为抗雌激素抗性。乳腺癌抗雌激素抗性基因3在寻求参与雌激素抗性的发展的基因被确定。的基因编码，导致雌激素非依赖性增殖的人类乳腺癌细胞的细胞内信号转导的一个组成部分。该蛋白含有推定的Src同源2（SH2）结构域，细胞酪氨酸激酶信号传导分子的一个大厅标记，并且部分是同源的细胞分裂周期蛋白CDC48。已发现该基因编码不同亚型的多个抄本变形。 [由RefSeq的，2012年5月提供]
基因本体信息
BCAR3基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
BCAR3基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Mammary Neoplasms | 0.128444493 | 5 | 0 | BeFree_CTD_human_LHGDN |
| Substance-Related Disorders | 0.12 | 1 | 0 | CTD_human |
| Breast Carcinoma | 0.002442977 | 9 | 0 | BeFree |
| Malignant neoplasm of breast | 0.002442977 | 9 | 0 | BeFree |
| Invasive breast carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Gastroenteritis | 0.000542884 | 2 | 0 | BeFree |
| Chikungunya Fever | 0.000271442 | 1 | 0 | BeFree |
| Venezuelan equine encephalomyelitis | 0.000271442 | 1 | 0 | BeFree |
| Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Severe Acute Respiratory Syndrome | 0.000271442 | 1 | 0 | BeFree |
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