BCAR1 (BCAR1 scaffold protein, Cas family member)

基因基本信息

基因基本信息

symbol:
BCAR1
locus group:
protein-coding gene
location:
16q23.1
gene_family:
Cas scaffolding proteins
alias symbol:
P130Cas|Crkas|CAS|CASS1
alias name:
Crk-associated substrate|Cas scaff…
entrez id:
9564
ensembl gene id:
ENSG00000050820
ucsc gene id:
uc002fdv.4
refseq accession:
NM_014567
hgnc_id:
HGNC:971
approved reserved:
1999-04-29

基因染色体位置

基因染色体位置

16q23.1
基因染色体位置图

基因简述

基因简述

BCAR1（Breast Cancer Anti-Estrogen Resistance 1）是一种多功能支架蛋白，主要参与细胞黏附、迁移和信号转导过程。它也被称为p130Cas（Crk-associated substrate），属于CAS（Crk-associated substrate）基因家族。该家族成员（如NEDD9、HEF1、EFS）的共同特点是含有多个蛋白相互作用结构域，如SH3结合域、底物结构域（SD）和富含脯氨酸的区域，这些结构域使其能够与多种信号分子结合，参与细胞骨架重组、增殖和存活等过程。BCAR1在整合素介导的信号通路中起关键作用，通过与Crk、FAK（黏着斑激酶）和SRC等蛋白相互作用，调控细胞外基质感知和细胞运动。突变或异常表达可能影响其功能，例如某些突变会导致BCAR1失去与Crk的结合能力，从而破坏下游信号传导，影响细胞迁移和侵袭。BCAR1的过表达与多种癌症相关，尤其是乳腺癌、肺癌和胶质母细胞瘤，因为它能增强肿瘤细胞的侵袭性和抗药性（如对抗雌激素治疗的抵抗）。此外，BCAR1高表达可能激活PI3K/AKT和MAPK通路，促进细胞存活和增殖。相反，降低BCAR1表达会抑制肿瘤转移，但可能影响正常细胞的黏附功能。在非病理状态下，BCAR1对胚胎发育、免疫细胞功能和血管生成也有重要作用。其表达水平受转录因子（如ETS1）和表观遗传调控影响。研究还发现BCAR1与炎症性疾病（如关节炎）相关，因其参与白细胞迁移。总体而言，BCAR1是细胞行为的关键调节因子，其功能失衡可能导致疾病，尤其是癌症进展。

BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM, May 2009]

BCAR1，或CAS，是参与各种细胞的活动，包括迁移，存活，转化和侵袭中的Src（MIM 190090）家族激酶基板（泽田等，2006 [考研17129785]）通过提供OMIM，2009年5月]

OMIM数据库中对CCND1基因的介绍     Wikipedia数据库中对CCND1基因的介绍

基因序列

基因序列

CCND1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

BCAR1基因的碱基突变：           仅显示部分snp
rs5842       rs730367       rs889514       rs1035539       rs1035540       rs1469121       rs1862737       rs1862738       rs2059249       rs2081214       rs2278020       rs2870471       rs2870472       rs3169330       rs3743613       rs3743614       rs3784938      

基因表达

基因表达

BCAR1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
CAAGGCCTCTACCAAGTCC
60
TTCGAGAAGGTGGATGTCTG
60
ATAAAGGCATCTGCTGTGG
58
AAGATCTTGAGGCGGTTCC
60
TTGAGAAGACCCAGAAGGAG
59
TTCAAACTGCTTCAGCTGC
59
GCAAGGGTGACATCATGAC
59
AAGATCTTGAGGCGGTTCC
60
AGGGCTATGTATACGAGGC
58
TGTGTCATACACCTCCTGG
59
CTATGTATACGAGGCCGCC
60
GAACGTCGTAGACCTCCTG
60
AGTTCTGGACTTCTCTGGC
59
CTAATCACTACTGCCCTGGG
60
GGCTTCTAAGAGGAGGCAG
60
CACATTGTCATAGAGCGCT
58
CAAGGCCTCTACCAAGTCC
60
TCGAGAAGGTGGATGTCTG
59
GGCTTCTAAGAGGAGGCAG
60
ATTGTCATAGAGCGCTTTGG
59

转录因子

转录因子

转录因子
影响基因
影响类型
参考文献链接（PubMed）
EGR1
BCAR1
Activation
22431919
NAB2
BCAR1
Activation
22431919

基因本体信息

BCAR1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

BCAR1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004871
H3BN62 (UniProtKB)
IEA
GO:0007165
H3BN62 (UniProtKB)
IEA
GO:0004871
H3BQJ7 (UniProtKB)
IEA
GO:0007165
H3BQJ7 (UniProtKB)
IEA
GO:0004871
H3BSB2 (UniProtKB)
IEA
GO:0007165
H3BSB2 (UniProtKB)
IEA
GO:0004871
H3BSY4 (UniProtKB)
IEA
GO:0007165
H3BSY4 (UniProtKB)
IEA
GO:0004871
H3BTB0 (UniProtKB)
IEA
GO:0007165
H3BTB0 (UniProtKB)
IEA
GO:0004871
H3BTL5 (UniProtKB)
IEA
GO:0007165
H3BTL5 (UniProtKB)
IEA
GO:0004871
H3BU42 (UniProtKB)
IEA
GO:0007165
H3BU42 (UniProtKB)
IEA
GO:0004871
H3BVF0 (UniProtKB)
IEA
GO:0007165
H3BVF0 (UniProtKB)
IEA
GO:0001558
P56945 (UniProtKB)
TAS
GO:0001726
P56945 (UniProtKB)
IDA
GO:0004871
P56945 (UniProtKB)
IEA
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005515
P56945 (UniProtKB)
IPI
GO:0005730
P56945 (UniProtKB)
IDA
GO:0005737
P56945 (UniProtKB)
IDA
GO:0005737
P56945 (UniProtKB)
IDA
GO:0005829
P56945 (UniProtKB)
TAS
GO:0005829
P56945 (UniProtKB)
TAS
GO:0005829
P56945 (UniProtKB)
TAS
GO:0005829
P56945 (UniProtKB)
TAS
GO:0005829
P56945 (UniProtKB)
TAS
GO:0005829
P56945 (UniProtKB)
TAS
GO:0005829
P56945 (UniProtKB)
TAS
GO:0005829
P56945 (UniProtKB)
TAS
GO:0005829
P56945 (UniProtKB)
TAS
GO:0005886
P56945 (UniProtKB)
IDA
GO:0005925
P56945 (UniProtKB)
ISS
GO:0005925
P56945 (UniProtKB)
IDA
GO:0005925
P56945 (UniProtKB)
IDA
GO:0007015
P56945 (UniProtKB)
IDA
GO:0007155
P56945 (UniProtKB)
IEA
GO:0007173
P56945 (UniProtKB)
ISS
GO:0007186
P56945 (UniProtKB)
ISS
GO:0007186
P56945 (UniProtKB)
NAS
GO:0007229
P56945 (UniProtKB)
IDA
GO:0008283
P56945 (UniProtKB)
TAS
GO:0008286
P56945 (UniProtKB)
ISS
GO:0010595
P56945 (UniProtKB)
IDA
GO:0015629
P56945 (UniProtKB)
IEA
GO:0016477
P56945 (UniProtKB)
IDA
GO:0017124
P56945 (UniProtKB)
IEA
GO:0019901
P56945 (UniProtKB)
IPI
GO:0019901
P56945 (UniProtKB)
IPI
GO:0019901
P56945 (UniProtKB)
IPI
GO:0019901
P56945 (UniProtKB)
IPI
GO:0019901
P56945 (UniProtKB)
IPI
GO:0019901
P56945 (UniProtKB)
IPI
GO:0030027
P56945 (UniProtKB)
IEA
GO:0030335
P56945 (UniProtKB)
IDA
GO:0035729
P56945 (UniProtKB)
IMP
GO:0042981
P56945 (UniProtKB)
TAS
GO:0048008
P56945 (UniProtKB)
ISS
GO:0048010
P56945 (UniProtKB)
IMP
GO:0048010
P56945 (UniProtKB)
TAS
GO:0048011
P56945 (UniProtKB)
ISS
GO:0048012
P56945 (UniProtKB)
IMP
GO:0050851
P56945 (UniProtKB)
IDA
GO:0050852
P56945 (UniProtKB)
NAS
GO:0050853
P56945 (UniProtKB)
IDA
GO:0051301
P56945 (UniProtKB)
NAS
GO:0060326
P56945 (UniProtKB)
IMP
GO:0005886
P56945 (UniProtKB)
IDA

基因相关microRNA

基因相关microRNA

可能调控 BCAR1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Pancreatic Neoplasm 0.122367032 1 1 CTD_human_GAD
Neoplasm Invasiveness 0.12 1 0 CTD_human
Malignant neoplasm of pancreas 0.12 1 1 GWASCAT
Mammary Neoplasms 0.009801702 8 0 BeFree_LHGDN
Malignant neoplasm of breast 0.007328931 27 0 BeFree
Breast Carcinoma 0.006786047 25 0 BeFree
melanoma 0.006534468 4 0 BeFree_LHGDN
Liver carcinoma 0.003267234 3 0 BeFree_LHGDN
Colonic Neoplasms 0.00272435 1 0 LHGDN
Prostatic Neoplasms 0.00272435 1 0 LHGDN

基因相关服务

基因相关服务

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