BAD基因详情-基因数据库-基因云馆

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BAD (BCL2 associated agonist of cell death)

symbol:: BAD
locus group:: protein-coding gene
location:: 11q13.1
gene_family:
alias symbol:: BCL2L8|BBC2
alias name:: None
entrez id:: 572
ensembl gene id:: ENSG00000002330
ucsc gene id:: uc001nzd.4
refseq accession:: NM_032989
hgnc_id:: HGNC:936
approved reserved:: 1997-10-16

11q13.1

BAD基因（BCL2-associated agonist of cell death）属于BCL-2蛋白家族，该家族成员主要调控细胞凋亡（程序性细胞死亡）过程。BAD基因编码的蛋白是一种促凋亡蛋白，通过与抗凋亡蛋白（如BCL-2和BCL-XL）结合并抑制其功能，从而促进细胞凋亡。BAD蛋白的活性受磷酸化调控，当被磷酸化时（如通过AKT或PKA激酶），它会与14-3-3蛋白结合并失去促凋亡活性；而去磷酸化则恢复其功能。BAD的主要作用位点是线粒体，它通过干扰BCL-2家族蛋白的平衡来触发线粒体外膜通透性增加，释放细胞色素C并激活凋亡信号通路。BAD基因突变可能导致其功能异常，例如失去促凋亡能力或持续激活，进而与癌症、神经退行性疾病等病理过程相关。若BAD过表达，可能增强细胞凋亡，导致组织损伤或发育异常；而降低表达则可能抑制凋亡，促进肿瘤细胞存活。BCL-2家族蛋白的共同特点是含有BH（BCL-2 homology）结构域，通过蛋白间相互作用调控凋亡。该家族包括促凋亡（如BAX、BAK）和抗凋亡（如BCL-2、BCL-XL）成员，共同维持细胞生死平衡。

The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]

由该基因编码的蛋白质是BCL-2家族的一个成员。 BCL-2的FAMILY成员是已知的程序性细胞死亡的调节剂。该蛋白通过与BCL-xL和BCL-2的异二聚体，并且扭转他们??的死亡阻抑物活性正调节细胞凋亡。这种蛋白质的促凋亡活性是通过其磷酸化调节。蛋白激酶AKT和MAP激酶，以及蛋白磷酸酶钙调磷酸酶被发现参与该蛋白质的调节。该基因导致两个转录变体，其编码相同的同种型的选择性剪接。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CCND1基因的介绍 Wikipedia数据库中对CCND1基因的介绍

CCND1基因的碱基序列：[NCBI]

Loading Gene Browser...

BAD基因的碱基突变：仅显示部分snp

rs10556 rs15934 rs477895 rs652611 rs660442 rs671976 rs687735 rs876064 rs887314 rs1050029 rs1199424 rs1213140 rs1468558 rs2286615 rs2286616 rs2510066 rs3729933

BAD基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

ACAGCTTCACAGAAACTGG

GAAGTCCCTTCTTAAAGGAGTC

TCATGGAGGGAGAACTTCG

TACATTCTCTGCGTGTTGG

ACTCCTTTAAGAAGGGACTTCC

CACCAGGACTGGAAGACTC

ACTCCTTTAAGAAGGGACTTCC

CACCAGGACTGGAAGACTC

TCATGGAGGGAGAACTTCG

TACATTCTCTGCGTGTTGG

CAGCTTCACAGAAACTGGG

GAAGTCCCTTCTTAAAGGAGTC

GTGAGCAGGAAGACTCCAG

AAGTCCCTTCTCCATGATGG

GGAGCTGAGATTAACGTCG

AAGTCCCTTCTTAAAGGAGTC

CTCCTTTAAGAAGGGACTTCCT

CACCAGGACTGGAAGACTC

ATCATGGAGGGAGAACTTCG

TGTTGGGCTTCTGAGTCAG

转录因子

影响基因

影响类型

参考文献链接（PubMed）

NR3C1

BAD

Activation

17496926

PPARG

BAD

Activation

14960510

RELA

BAD

Activation

20596645

BAD基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

BAD基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0006915

A8MXU7 (UniProtKB)

IEA

GO:0006915

F5GYS3 (UniProtKB)

IEA

GO:0006915

F5H1R6 (UniProtKB)

IEA

GO:0006915

F5H3B1 (UniProtKB)

IEA

GO:0001836

Q92934 (UniProtKB)

IEA

GO:0001844

Q92934 (UniProtKB)

TAS

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005515

Q92934 (UniProtKB)

IPI

GO:0005543

Q92934 (UniProtKB)

IMP

GO:0005739

Q92934 (UniProtKB)

IDA

GO:0005741

Q92934 (UniProtKB)

IDA

GO:0005741

Q92934 (UniProtKB)

TAS

GO:0005741

Q92934 (UniProtKB)

TAS

GO:0005741

Q92934 (UniProtKB)

TAS

GO:0005829

Q92934 (UniProtKB)

IDA

GO:0005829

Q92934 (UniProtKB)

TAS

GO:0005829

Q92934 (UniProtKB)

TAS

GO:0005829

Q92934 (UniProtKB)

TAS

GO:0005829

Q92934 (UniProtKB)

TAS

GO:0005829

Q92934 (UniProtKB)

TAS

GO:0006007

Q92934 (UniProtKB)

IEA

GO:0006915

Q92934 (UniProtKB)

IDA

GO:0006915

Q92934 (UniProtKB)

TAS

GO:0006919

Q92934 (UniProtKB)

ISS

GO:0007283

Q92934 (UniProtKB)

IEA

GO:0008289

Q92934 (UniProtKB)

IDA

GO:0008625

Q92934 (UniProtKB)

IEA

GO:0008630

Q92934 (UniProtKB)

IEA

GO:0008656

Q92934 (UniProtKB)

IDA

GO:0009749

Q92934 (UniProtKB)

IEA

GO:0010508

Q92934 (UniProtKB)

TAS

GO:0010918

Q92934 (UniProtKB)

ISS

GO:0019050

Q92934 (UniProtKB)

IEA

GO:0019221

Q92934 (UniProtKB)

IEA

GO:0019901

Q92934 (UniProtKB)

IPI

GO:0021987

Q92934 (UniProtKB)

IEA

GO:0030346

Q92934 (UniProtKB)

IEA

GO:0032024

Q92934 (UniProtKB)

ISS

GO:0032355

Q92934 (UniProtKB)

IEA

GO:0032570

Q92934 (UniProtKB)

IEA

GO:0033133

Q92934 (UniProtKB)

ISS

GO:0033574

Q92934 (UniProtKB)

IEA

GO:0034201

Q92934 (UniProtKB)

IEA

GO:0035774

Q92934 (UniProtKB)

IEA

GO:0042493

Q92934 (UniProtKB)

IEA

GO:0042542

Q92934 (UniProtKB)

IEA

GO:0042593

Q92934 (UniProtKB)

ISS

GO:0043065

Q92934 (UniProtKB)

IMP

GO:0043065

Q92934 (UniProtKB)

IDA

GO:0043065

Q92934 (UniProtKB)

TAS

GO:0043200

Q92934 (UniProtKB)

IEA

GO:0043280

Q92934 (UniProtKB)

IDA

GO:0043422

Q92934 (UniProtKB)

IEA

GO:0044342

Q92934 (UniProtKB)

ISS

GO:0045471

Q92934 (UniProtKB)

IEA

GO:0045579

Q92934 (UniProtKB)

IEA

GO:0045582

Q92934 (UniProtKB)

IEA

GO:0045862

Q92934 (UniProtKB)

IDA

GO:0045918

Q92934 (UniProtKB)

IMP

GO:0046031

Q92934 (UniProtKB)

ISS

GO:0046034

Q92934 (UniProtKB)

ISS

GO:0046902

Q92934 (UniProtKB)

IMP

GO:0046931

Q92934 (UniProtKB)

IDA

GO:0046931

Q92934 (UniProtKB)

IDA

GO:0046982

Q92934 (UniProtKB)

IEA

GO:0050679

Q92934 (UniProtKB)

IMP

GO:0051384

Q92934 (UniProtKB)

IEA

GO:0051592

Q92934 (UniProtKB)

IEA

GO:0060139

Q92934 (UniProtKB)

IEA

GO:0060154

Q92934 (UniProtKB)

IEA

GO:0071247

Q92934 (UniProtKB)

IEA

GO:0071260

Q92934 (UniProtKB)

IEP

GO:0071316

Q92934 (UniProtKB)

IDA

GO:0071396

Q92934 (UniProtKB)

IEA

GO:0071456

Q92934 (UniProtKB)

IEP

GO:0071889

Q92934 (UniProtKB)

IEA

GO:0090200

Q92934 (UniProtKB)

IMP

GO:0097191

Q92934 (UniProtKB)

IMP

GO:0097192

Q92934 (UniProtKB)

IEA

GO:0097193

Q92934 (UniProtKB)

IMP

GO:0097202

Q92934 (UniProtKB)

IDA

GO:1900740

Q92934 (UniProtKB)

TAS

GO:1901216

Q92934 (UniProtKB)

IEA

GO:2000078

Q92934 (UniProtKB)

ISS

GO:2001244

Q92934 (UniProtKB)

TAS

可能调控 BAD基因的相关microRNA：

hsa-miR-126 hsa-miR-126* hsa-miR-15a hsa-miR-15a* hsa-miR-15b hsa-miR-15b* hsa-miR-16 hsa-miR-205 hsa-miR-21* hsa-miR-330-5p

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
4014 Ras signaling pathway [PATH:hsa04014]
4012 ErbB signaling pathway [PATH:hsa04012]
4370 VEGF signaling pathway [PATH:hsa04370]
4024 cAMP signaling pathway [PATH:hsa04024]
4022 cGMP - PKG signaling pathway [PATH:hsa04022]
4151 PI3K-Akt signaling pathway [PATH:hsa04151]
4210 Apoptosis [PATH:hsa04210]
4510 Focal adhesion [PATH:hsa04510]
4910 Insulin signaling pathway [PATH:hsa04910]
4919 Thyroid hormone signaling pathway [PATH:hsa04919]
4722 Neurotrophin signaling pathway [PATH:hsa04722]
5200 Pathways in cancer [PATH:hsa05200]
5203 Viral carcinogenesis [PATH:hsa05203]
5210 Colorectal cancer [PATH:hsa05210]
5212 Pancreatic cancer [PATH:hsa05212]
5221 Acute myeloid leukemia [PATH:hsa05221]
5220 Chronic myeloid leukemia [PATH:hsa05220]
5218 Melanoma [PATH:hsa05218]
5215 Prostate cancer [PATH:hsa05215]
5213 Endometrial cancer [PATH:hsa05213]
5223 Non-small cell lung cancer [PATH:hsa05223]
5010 Alzheimer's disease [PATH:hsa05010]
5014 Amyotrophic lateral sclerosis (ALS) [PATH:hsa05014]
5152 Tuberculosis [PATH:hsa05152]
5161 Hepatitis B [PATH:hsa05161]
5160 Hepatitis C [PATH:hsa05160]
5145 Toxoplasmosis [PATH:hsa05145]

名称
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Adaptive Immune System
AKT phosphorylates targets in the cytosol
Apoptosis
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Cell death signalling via NRAGE, NRIF and NADE
Constitutive Signaling by AKT1 E17K in Cancer
DAP12 interactions
DAP12 signaling
Disease
Diseases of signal transduction
Downstream signal transduction
Downstream signaling events of B Cell Receptor (BCR)
Downstream signaling of activated FGFR1
Downstream signaling of activated FGFR2
Downstream signaling of activated FGFR3
Downstream signaling of activated FGFR4
Fc epsilon receptor (FCERI) signaling
GAB1 signalosome
Immune System
Innate Immune System
Intrinsic Pathway for Apoptosis
NGF signalling via TRKA from the plasma membrane
NRAGE signals death through JNK
p75 NTR receptor-mediated signalling
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
PI3K events in ERBB2 signaling
PI3K events in ERBB4 signaling
PI3K/AKT activation
PI3K/AKT Signaling in Cancer
PIP3 activates AKT signaling
Programmed Cell Death
Role of LAT2/NTAL/LAB on calcium mobilization
Signal Transduction
Signaling by EGFR
Signaling by ERBB2
Signaling by ERBB4
Signaling by FGFR
Signaling by FGFR1
Signaling by FGFR2
Signaling by FGFR3
Signaling by FGFR4
Signaling by PDGF
Signaling by SCF-KIT
Signaling by the B Cell Receptor (BCR)
Signalling by NGF

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Prostatic Neoplasms	0.128715934	6	0	BeFree_CTD_human_LHGDN
Transient Ischemic Attack	0.12	1	0	CTD_human
leukemia	0.12	1	0	CTD_human
Platelet mean volume finding	0.12	1	1	GWASCAT
Colonic Neoplasms	0.088173051	4	0	LHGDN_RGD
Glioma	0.081357209	6	0	BeFree_RGD
Hypothyroidism	0.08	1	0	RGD
Seizures	0.08	1	0	RGD
Gastric ulcer	0.08	1	0	RGD
Insulin Resistance	0.08	1	0	RGD

联系方式

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更新于2天前

BAD (BCL2 associated agonist of cell death)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

联系方式

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