ANXA1 (annexin A1)

基因基本信息

基因基本信息

symbol:
ANXA1
locus group:
protein-coding gene
location:
9q21.13
gene_family:
Annexins|Endogenous ligands
alias symbol:
None
alias name:
None
entrez id:
301
ensembl gene id:
ENSG00000135046
ucsc gene id:
uc004ajf.2
refseq accession:
NM_000700
hgnc_id:
HGNC:533
approved reserved:
2001-06-22

基因染色体位置

基因染色体位置

9q21.13
基因染色体位置图

基因简述

基因简述

ANXA1（膜联蛋白A1）是一种属于膜联蛋白（Annexin）基因家族的钙依赖性磷脂结合蛋白，在多种生理和病理过程中发挥关键作用。该基因家族共有12个成员（ANXA1-ANXA13，其中ANXA12未被确认），其共性是通过钙离子介导与细胞膜磷脂结合，参与细胞信号传导、膜修复、炎症调控和凋亡等过程。ANXA1主要表达于免疫细胞（如中性粒细胞、巨噬细胞）、上皮细胞和内分泌组织，其表达产物是一种37kDa的蛋白质，可通过与甲酰肽受体（FPRs）相互作用发挥抗炎作用。该蛋白的N端结构域含有糖皮质激素调控位点，是其抗炎功能的核心区域。ANXA1通过抑制磷脂酶A2和核因子κB（NF-κB）通路来减少促炎因子（如白细胞介素-6、肿瘤坏死因子-α）的产生，同时促进炎症消退。突变可能导致其抗炎功能丧失，与慢性炎症性疾病（如类风湿关节炎、哮喘）和肿瘤发生相关。ANXA1过表达可增强抗炎效应，但可能抑制免疫监视功能，促进某些癌症（如乳腺癌、前列腺癌）的转移；而表达降低则会导致炎症反应失控，与自身免疫疾病和神经退行性疾病（如阿尔茨海默病）相关。该基因还参与细胞凋亡调控，过表达可诱导肿瘤细胞凋亡，但在某些环境下反而促进细胞存活。ANXA1与糖皮质激素受体相互作用，介导糖皮质激素的抗炎作用，这使得它成为炎症性疾病治疗的潜在靶点。在癌症中，ANXA1的表达具有组织特异性，既可作为抑癌基因（如在前列腺癌中），也可作为促癌因子（如在胰腺癌中），这种双重角色可能与肿瘤微环境差异有关。此外，ANXA1还参与血管生成、细胞增殖和迁移等过程，其表达水平变化会影响多种信号通路（如EGFR、MAPK）的活性。

This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]

这个基因编码能结合磷脂的膜局部化的蛋白质。该蛋白质抑制磷脂酶A2和具有抗炎活性。的功能或该基因的表达丢失已经在多种肿瘤中检测到。 [由RefSeq的，2014年12月提供]

OMIM数据库中对ANXA1基因的介绍     Wikipedia数据库中对ANXA1基因的介绍

基因序列

基因序列

ANXA1基因的碱基序列：[NCBI]
Loading Gene Browser...

基因突变

基因突变

ANXA1基因的碱基突变：           仅显示部分snp
rs9561       rs1050305       rs1131072       rs1342017       rs1342018       rs1981288       rs2310312       rs2795108       rs2795109       rs2795110       rs2795111       rs2795112       rs2795113       rs2795114       rs2795115       rs2795116       rs2795117      

基因表达

基因表达

ANXA1基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向Tm值
反向引物序列
反向Tm值
评分
GCAAGAAGGTAGAGATAAAGACAC
59
TGGATTGAAGGTAGGATAGGG
59
AACCTCAGACACATCTGGAG
59
CTGCTTCATACAAGGCCCT
60
GAAATGCCTCACAGCTATCG
59
TCCAACACCTTTCATGGCT
60
AACTTCGCAGAGTGTTTCAG
59
TCACCTTTCAACTCCAGGTC
60
GAAATGCCTCACAGCTATCG
59
TCCAACACCTTTCATGGCT
60
AGCCATCCTGGATGAAACC
60
TAGCTTGAGACCATCAAGGG
59
CCATAATGGTTAAAGGTGTGGA
59
TTGATCTGTTGACGCTGTG
59
CCATAATGGTTAAAGGTGTGGA
59
TTGATCTGTTGACGCTGTG
59
TTCTCTTGCTAAGGGTGACC
60
TCTCCTGCTTCATACAAGGC
60
CCATAATGGTTAAAGGTGTGGA
59
TTGATCTGTTGACGCTGTG
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

ANXA1基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

" d="M482.414,245.296c3.539,4.293,4.455,10.009,0.202,11 c-4.244,0.996-4.983-10.983-8.293-8.438c-5.271,4.08,9.834,12.271,5.144,17.287c-3.717,3.607-6.172-5.75-10.839-1.976 c-4.673,3.776,6.781,7.299,2.831,11.326c-4.354,4.045-6.979-1.449-9.837-5.517c-1.193-1.742-2.059-3.851-3.595-2.748 c-1.516,1.078-1.854,1.795-0.938,3.666c2.374,4.854,9.235,10.119,5.156,12.535c-5.636,3.346-5.044-8.871-9.426-7.574 c-4.388,1.291,2.557,10.66-1.245,11.141c-4.089,0.545-3.483-10.239-6.979-8.575c-2.522,1.206-0.929,3.071-0.938,4.899 c0.004,1.32-0.964,3.6-2.372,4.062c-3.593,1.171-8.544-1.065-10.251-3.59c-6.04-8.93,0.396-15.997,4.639-7.015 c3.023,4.642,5.182,0.834,2.839-2.219c-1.032-1.354-4.309-5.901-0.781-7.252c2.904-1.113,4.271,1.941,5.985,4.592 c2.61,4.016,5.485,0.117,3.031-3.414c-1.828-2.633-2.74-3.803,3.156-7.42c6.405-4.369,6.52,3.869,10.077,0.646 c2.309-1.832-4.783-5.149,0.06-8.995c2.896-2.293,5.18,6.207,7.961,3.516c3.523-2.737-7.717-7.369,0.117-11.736 C473.413,240.77,480.519,242.891,482.414,245.296z"/> Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 质膜
  • 细胞质
  • 细胞外
  • 高尔基体
  • 囊泡
  • 细胞骨架
  • 内质网
  • 细胞核
  • 内体
  • 溶酶体
  • 线粒体

ANXA1基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000733
P04083 (UniProtKB)
IEA
GO:0001533
P04083 (UniProtKB)
IDA
GO:0001780
P04083 (UniProtKB)
IMP
GO:0001891
P04083 (UniProtKB)
IEA
GO:0002250
P04083 (UniProtKB)
IEA
GO:0002548
P04083 (UniProtKB)
IDA
GO:0002685
P04083 (UniProtKB)
ISS
GO:0003697
P04083 (UniProtKB)
IEA
GO:0003727
P04083 (UniProtKB)
IEA
GO:0004386
P04083 (UniProtKB)
IEA
GO:0005102
P04083 (UniProtKB)
TAS
GO:0005198
P04083 (UniProtKB)
IDA
GO:0005509
P04083 (UniProtKB)
ISS
GO:0005515
P04083 (UniProtKB)
IPI
GO:0005515
P04083 (UniProtKB)
IPI
GO:0005543
P04083 (UniProtKB)
TAS
GO:0005544
P04083 (UniProtKB)
IDA
GO:0005576
P04083 (UniProtKB)
TAS
GO:0005576
P04083 (UniProtKB)
TAS
GO:0005576
P04083 (UniProtKB)
TAS
GO:0005576
P04083 (UniProtKB)
TAS
GO:0005576
P04083 (UniProtKB)
TAS
GO:0005576
P04083 (UniProtKB)
TAS
GO:0005576
P04083 (UniProtKB)
TAS
GO:0005576
P04083 (UniProtKB)
TAS
GO:0005615
P04083 (UniProtKB)
IDA
GO:0005615
P04083 (UniProtKB)
IDA
GO:0005615
P04083 (UniProtKB)
IDA
GO:0005615
P04083 (UniProtKB)
IDA
GO:0005615
P04083 (UniProtKB)
IDA
GO:0005634
P04083 (UniProtKB)
IDA
GO:0005654
P04083 (UniProtKB)
IDA
GO:0005737
P04083 (UniProtKB)
IDA
GO:0005737
P04083 (UniProtKB)
TAS
GO:0005737
P04083 (UniProtKB)
IDA
GO:0005737
P04083 (UniProtKB)
IDA
GO:0005737
P04083 (UniProtKB)
IDA
GO:0005768
P04083 (UniProtKB)
IDA
GO:0005886
P04083 (UniProtKB)
IDA
GO:0005925
P04083 (UniProtKB)
IDA
GO:0006909
P04083 (UniProtKB)
ISS
GO:0006954
P04083 (UniProtKB)
ISS
GO:0007165
P04083 (UniProtKB)
TAS
GO:0007166
P04083 (UniProtKB)
IEA
GO:0007187
P04083 (UniProtKB)
IMP
GO:0007187
P04083 (UniProtKB)
IDA
GO:0008360
P04083 (UniProtKB)
IDA
GO:0009986
P04083 (UniProtKB)
IDA
GO:0010165
P04083 (UniProtKB)
IEA
GO:0014839
P04083 (UniProtKB)
IEA
GO:0016323
P04083 (UniProtKB)
IEA
GO:0016324
P04083 (UniProtKB)
ISS
GO:0016328
P04083 (UniProtKB)
ISS
GO:0018149
P04083 (UniProtKB)
IDA
GO:0019834
P04083 (UniProtKB)
IDA
GO:0019834
P04083 (UniProtKB)
IDA
GO:0019898
P04083 (UniProtKB)
IDA
GO:0030073
P04083 (UniProtKB)
IEA
GO:0030216
P04083 (UniProtKB)
IDA
GO:0030659
P04083 (UniProtKB)
IEA
GO:0030674
P04083 (UniProtKB)
IDA
GO:0030850
P04083 (UniProtKB)
IEA
GO:0031018
P04083 (UniProtKB)
IEA
GO:0031232
P04083 (UniProtKB)
IDA
GO:0031313
P04083 (UniProtKB)
ISS
GO:0031340
P04083 (UniProtKB)
IDA
GO:0031394
P04083 (UniProtKB)
IEA
GO:0031514
P04083 (UniProtKB)
ISS
GO:0031532
P04083 (UniProtKB)
IDA
GO:0031901
P04083 (UniProtKB)
ISS
GO:0031966
P04083 (UniProtKB)
IEA
GO:0031982
P04083 (UniProtKB)
IDA
GO:0032355
P04083 (UniProtKB)
IEA
GO:0032508
P04083 (UniProtKB)
IEA
GO:0032652
P04083 (UniProtKB)
ISS
GO:0032743
P04083 (UniProtKB)
IDA
GO:0033031
P04083 (UniProtKB)
IEA
GO:0033676
P04083 (UniProtKB)
IEA
GO:0036292
P04083 (UniProtKB)
IEA
GO:0036310
P04083 (UniProtKB)
IEA
GO:0042063
P04083 (UniProtKB)
IEA
GO:0042102
P04083 (UniProtKB)
IDA
GO:0042383
P04083 (UniProtKB)
IEA
GO:0042493
P04083 (UniProtKB)
IEA
GO:0042629
P04083 (UniProtKB)
IEA
GO:0042803
P04083 (UniProtKB)
IEA
GO:0043066
P04083 (UniProtKB)
TAS
GO:0043234
P04083 (UniProtKB)
IEA
GO:0043434
P04083 (UniProtKB)
IEA
GO:0044849
P04083 (UniProtKB)
IEA
GO:0045087
P04083 (UniProtKB)
IEA
GO:0045627
P04083 (UniProtKB)
IDA
GO:0045629
P04083 (UniProtKB)
IDA
GO:0045920
P04083 (UniProtKB)
IMP
GO:0046632
P04083 (UniProtKB)
ISS
GO:0046883
P04083 (UniProtKB)
IMP
GO:0048306
P04083 (UniProtKB)
IPI
GO:0050482
P04083 (UniProtKB)
IEA
GO:0050727
P04083 (UniProtKB)
ISS
GO:0070062
P04083 (UniProtKB)
IDA
GO:0070062
P04083 (UniProtKB)
IDA
GO:0070062
P04083 (UniProtKB)
IDA
GO:0070062
P04083 (UniProtKB)
IDA
GO:0070062
P04083 (UniProtKB)
IDA
GO:0070062
P04083 (UniProtKB)
IDA
GO:0070301
P04083 (UniProtKB)
IEA
GO:0070365
P04083 (UniProtKB)
IEA
GO:0070459
P04083 (UniProtKB)
IEA
GO:0070555
P04083 (UniProtKB)
IEA
GO:0071385
P04083 (UniProtKB)
IDA
GO:0071621
P04083 (UniProtKB)
IDA
GO:0090303
P04083 (UniProtKB)
IDA
GO:0097350
P04083 (UniProtKB)
IMP
GO:1900087
P04083 (UniProtKB)
IEA
GO:1900138
P04083 (UniProtKB)
IEA
GO:2000483
P04083 (UniProtKB)
IMP
GO:0004859
Q5T3N0 (UniProtKB)
IEA
GO:0005509
Q5T3N0 (UniProtKB)
IEA
GO:0005544
Q5T3N0 (UniProtKB)
IEA
GO:0005654
Q5T3N0 (UniProtKB)
IDA
GO:0005737
Q5T3N0 (UniProtKB)
IDA
GO:0005886
Q5T3N0 (UniProtKB)
IDA
GO:0043086
Q5T3N0 (UniProtKB)
IEA
GO:0004859
Q5T3N1 (UniProtKB)
IEA
GO:0005509
Q5T3N1 (UniProtKB)
IEA
GO:0005544
Q5T3N1 (UniProtKB)
IEA
GO:0005654
Q5T3N1 (UniProtKB)
IDA
GO:0005737
Q5T3N1 (UniProtKB)
IDA
GO:0005886
Q5T3N1 (UniProtKB)
IDA
GO:0043086
Q5T3N1 (UniProtKB)
IEA

基因相关microRNA

基因相关microRNA

可能调控 ANXA1基因的相关microRNA：     

基因相互作用关系

基因相互作用关系

Reactome

MINT

BioGrid

IntAct

mentha

String

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因通路

基因通路

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Neoplasm Metastasis 0.202714419 11 0 BeFree_CTD_human_RGD
Mammary Neoplasms, Experimental 0.2 2 0 CTD_human_RGD
Hypertensive disease 0.2 2 0 CTD_human_RGD
Squamous cell carcinoma 0.12953026 9 0 BeFree_CTD_human_LHGDN
Prostatic Neoplasms 0.1254487 3 0 CTD_human_LHGDN
Adenocarcinoma of lung (disorder) 0.120542884 3 0 BeFree_CTD_human
Squamous cell carcinoma of esophagus 0.120542884 3 0 BeFree_CTD_human
Lymphatic Metastasis 0.120271442 2 0 BeFree_CTD_human
Neoplasm Invasiveness 0.12 1 0 CTD_human
Stomach Diseases 0.12 1 0 CTD_human

基因相关服务

基因相关服务

联系方式

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