AKT3基因详情-基因数据库-基因云馆

AKT3 (AKT serine/threonine kinase 3)

symbol:: AKT3
locus group:: protein-coding gene
location:: 1q43-q44
gene_family:: Pleckstrin homology domain containing
alias symbol:: PKBG|RAC-gamma|PRKBG
alias name:: protein kinase B, gamma
entrez id:: 10000
ensembl gene id:: ENSG00000117020
ucsc gene id:: uc057qvr.1
refseq accession:: NM_181690
hgnc_id:: HGNC:393
approved reserved:: 1999-11-16

1q43-q44

AKT3（也称为蛋白激酶Bγ或PKBγ）是AKT丝氨酸/苏氨酸激酶家族的成员之一，属于PI3K-AKT-mTOR信号通路的关键组成部分。AKT家族包括AKT1、AKT2和AKT3三个亚型，它们共享高度保守的结构域，包括PH结构域（用于膜定位）、激酶结构域（催化活性）和调节结构域（调控激酶活性）。AKT家族的主要功能是通过磷酸化下游靶蛋白调控细胞存活、增殖、代谢和生长。AKT3主要在神经系统高表达，尤其在发育中的大脑和成年大脑的某些区域（如海马和皮层）发挥重要作用。AKT3通过抑制凋亡、促进神经元存活和突触可塑性来维持神经功能。突变或表达异常可能导致多种疾病，例如AKT3功能获得性突变与巨脑畸形（大脑过度生长）相关，而功能丧失性突变可能与小头畸形或神经发育障碍有关。AKT3过表达可能促进细胞存活和增殖，增加癌症风险（如胶质瘤），同时可能通过激活mTOR通路导致代谢异常。相反，AKT3表达降低可能导致神经元凋亡增加，影响认知功能或神经发育。AKT3与其他AKT亚型功能部分冗余，但AKT3在神经系统中的作用更为特异。在癌症中，AKT3的异常激活可能与其他基因（如PTEN缺失）协同促进肿瘤进展。此外，AKT3还参与血管生成和胰岛素信号调控，但其作用较AKT2弱。研究AKT3有助于理解神经发育疾病和癌症的机制，并为靶向治疗提供潜在方向。

The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

由该基因编码的蛋白质是AKT的成员，也称为PKB，丝氨酸/苏氨酸蛋白激酶家族。 AKT激酶是已知的细胞信号传导的调节以响应胰岛素和生长因子。它们涉及多种生物学过程，包括细胞增殖，分化，细胞凋亡，肿瘤发生，以及糖原合成和糖摄取。这种激酶已经显示出通过血小板衍生的生长因子（PDGF），胰岛素和胰岛素样生长因子1（IGF1）刺激。可替代地剪接编码不同同种型的转录变体已有描述。 [由RefSeq的，2008年7月提供]

OMIM数据库中对AKT3基因的介绍 Wikipedia数据库中对AKT3基因的介绍

AKT3基因的碱基序列：[NCBI]

Loading Gene Browser...

AKT3基因的碱基突变：仅显示部分snp

rs14403 rs14403 rs16356 rs16356 rs167661 rs167661 rs172777 rs172777 rs184395 rs184395 rs184397 rs184397 rs186480 rs186480 rs188868 rs188868 rs188869

AKT3基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

CTCAAGATGTGGATTTACCTTATCC

60

TTTGGCTTTGGTCGTTCTG

59

CATCCTTGAAATATTCCTTCCAGAC

60

AGAGCGAAACTCCATCTCG

60

ACAGATGGCTCATTCATAGGA

59

AACATAACACTACTTGCCACTG

59

CTGAAGGCTCAGATGATCC

57

CCTCTTCTAACCTAGACTTGG

57

TCTATGGTGCAGAAATTGTCTC

59

GATTCTCCAACTTGAGATCACG

59

TCTATGGTGCAGAAATTGTCTC

59

GATTCTCCAACTTGAGATCACG

59

AATCAGATGTCTCCAGTGGAC

60

TCTGTCCATTCTTCCCTTTCC

60

TCTATGGTGCAGAAATTGTCTC

59

GATTCTCCAACTTGAGATCACG

59

TCTATGGTGCAGAAATTGTCTC

59

GATTCTCCAACTTGAGATCACG

59

AATCAGATGTCTCCAGTGGAC

60

TCTGTCCATTCTTCCCTTTCC

60

尚未收录相关数据

AKT3基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

AKT3基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0000002

Q9Y243 (UniProtKB)

IMP

GO:0004672

Q9Y243 (UniProtKB)

TAS

GO:0004674

Q9Y243 (UniProtKB)

IDA

GO:0005515

Q9Y243 (UniProtKB)

IPI

GO:0005515

Q9Y243 (UniProtKB)

IPI

GO:0005515

Q9Y243 (UniProtKB)

IPI

GO:0005515

Q9Y243 (UniProtKB)

IPI

GO:0005515

Q9Y243 (UniProtKB)

IPI

GO:0005515

Q9Y243 (UniProtKB)

IPI

GO:0005524

Q9Y243 (UniProtKB)

IDA

GO:0005622

Q9Y243 (UniProtKB)

IBA

GO:0005654

Q9Y243 (UniProtKB)

IDA

GO:0005737

Q9Y243 (UniProtKB)

IDA

GO:0005794

Q9Y243 (UniProtKB)

IDA

GO:0005886

Q9Y243 (UniProtKB)

IDA

GO:0006468

Q9Y243 (UniProtKB)

TAS

GO:0007165

Q9Y243 (UniProtKB)

IMP

GO:0018105

Q9Y243 (UniProtKB)

IBA

GO:0035556

Q9Y243 (UniProtKB)

IBA

可能调控 AKT3基因的相关microRNA：

hsa-miR-124 hsa-miR-29c hsa-miR-122 hsa-miR-122* hsa-miR-15a hsa-miR-15a* hsa-miR-16 hsa-miR-221 hsa-miR-221* hsa-miR-222

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
4014 Ras signaling pathway [PATH:hsa04014]
4015 Rap1 signaling pathway [PATH:hsa04015]
4010 MAPK signaling pathway [PATH:hsa04010]
4012 ErbB signaling pathway [PATH:hsa04012]
4370 VEGF signaling pathway [PATH:hsa04370]
4630 Jak-STAT signaling pathway [PATH:hsa04630]
4668 TNF signaling pathway [PATH:hsa04668]
4066 HIF-1 signaling pathway [PATH:hsa04066]
4068 FoxO signaling pathway [PATH:hsa04068]
4071 Sphingolipid signaling pathway [PATH:hsa04071]
4024 cAMP signaling pathway [PATH:hsa04024]
4022 cGMP - PKG signaling pathway [PATH:hsa04022]
4151 PI3K-Akt signaling pathway [PATH:hsa04151]
4152 AMPK signaling pathway [PATH:hsa04152]
4150 mTOR signaling pathway [PATH:hsa04150]
4210 Apoptosis [PATH:hsa04210]
4510 Focal adhesion [PATH:hsa04510]
4530 Tight junction [PATH:hsa04530]
4550 Signaling pathways regulating pluripotency of stem cells [PATH:hsa04550]
4611 Platelet activation [PATH:hsa04611]
4620 Toll-like receptor signaling pathway [PATH:hsa04620]
4660 T cell receptor signaling pathway [PATH:hsa04660]
4662 B cell receptor signaling pathway [PATH:hsa04662]
4664 Fc epsilon RI signaling pathway [PATH:hsa04664]
4666 Fc gamma R-mediated phagocytosis [PATH:hsa04666]
4062 Chemokine signaling pathway [PATH:hsa04062]
4910 Insulin signaling pathway [PATH:hsa04910]
4922 Glucagon signaling pathway [PATH:hsa04922]
4920 Adipocytokine signaling pathway [PATH:hsa04920]
4915 Estrogen signaling pathway [PATH:hsa04915]
4914 Progesterone-mediated oocyte maturation [PATH:hsa04914]
4917 Prolactin signaling pathway [PATH:hsa04917]
4919 Thyroid hormone signaling pathway [PATH:hsa04919]
4261 Adrenergic signaling in cardiomyocytes [PATH:hsa04261]
4973 Carbohydrate digestion and absorption [PATH:hsa04973]
4725 Cholinergic synapse [PATH:hsa04725]
4728 Dopaminergic synapse [PATH:hsa04728]
4722 Neurotrophin signaling pathway [PATH:hsa04722]
4380 Osteoclast differentiation [PATH:hsa04380]
5200 Pathways in cancer [PATH:hsa05200]
5230 Central carbon metabolism in cancer [PATH:hsa05230]
5231 Choline metabolism in cancer [PATH:hsa05231]
5205 Proteoglycans in cancer [PATH:hsa05205]
5210 Colorectal cancer [PATH:hsa05210]
5212 Pancreatic cancer [PATH:hsa05212]
5214 Glioma [PATH:hsa05214]
5221 Acute myeloid leukemia [PATH:hsa05221]
5220 Chronic myeloid leukemia [PATH:hsa05220]
5218 Melanoma [PATH:hsa05218]
5211 Renal cell carcinoma [PATH:hsa05211]
5215 Prostate cancer [PATH:hsa05215]
5213 Endometrial cancer [PATH:hsa05213]
5222 Small cell lung cancer [PATH:hsa05222]
5223 Non-small cell lung cancer [PATH:hsa05223]
4932 Non-alcoholic fatty liver disease (NAFLD) [PATH:hsa04932]
5152 Tuberculosis [PATH:hsa05152]
5166 HTLV-I infection [PATH:hsa05166]
5162 Measles [PATH:hsa05162]
5164 Influenza A [PATH:hsa05164]
5161 Hepatitis B [PATH:hsa05161]
5160 Hepatitis C [PATH:hsa05160]
5169 Epstein-Barr virus infection [PATH:hsa05169]
5145 Toxoplasmosis [PATH:hsa05145]
5142 Chagas disease (American trypanosomiasis) [PATH:hsa05142]

名称
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Adaptive Immune System
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
AKT-mediated inactivation of FOXO1A
Apoptosis
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
Constitutive Signaling by AKT1 E17K in Cancer
Costimulation by the CD28 family
CTLA4 inhibitory signaling
DAP12 interactions
DAP12 signaling
Developmental Biology
Disease
Diseases of signal transduction
Downregulation of ERBB2:ERBB3 signaling
Downstream signal transduction
Downstream signaling events of B Cell Receptor (BCR)
Downstream signaling of activated FGFR1
Downstream signaling of activated FGFR2
Downstream signaling of activated FGFR3
Downstream signaling of activated FGFR4
Fc epsilon receptor (FCERI) signaling
G beta:gamma signalling through PI3Kgamma
G-protein beta:gamma signalling
GAB1 signalosome
Gene Expression
Generic Transcription Pathway
GPCR downstream signaling
GPVI-mediated activation cascade
Hemostasis
Immune System
Innate Immune System
Intrinsic Pathway for Apoptosis
Negative regulation of the PI3K/AKT network
NGF signalling via TRKA from the plasma membrane
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
PI3K events in ERBB2 signaling
PI3K events in ERBB4 signaling
PI3K/AKT activation
PI3K/AKT Signaling in Cancer
PIP3 activates AKT signaling
Platelet activation, signaling and aggregation
Programmed Cell Death
Regulation of beta-cell development
Regulation of gene expression in beta cells
Role of LAT2/NTAL/LAB on calcium mobilization
Signal Transduction
Signaling by EGFR
Signaling by ERBB2
Signaling by ERBB4
Signaling by FGFR
Signaling by FGFR1
Signaling by FGFR2
Signaling by FGFR3
Signaling by FGFR4
Signaling by GPCR
Signaling by PDGF
Signaling by SCF-KIT
Signaling by the B Cell Receptor (BCR)
Signaling by VEGF
Signalling by NGF
TP53 Regulates Metabolic Genes
Transcriptional Regulation by TP53
VEGFA-VEGFR2 Pathway
VEGFR2 mediated vascular permeability

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Hemimegalencephaly	0.121085767	4	0	BeFree_ORPHANET
Malformations of Cortical Development	0.120271442	2	0	BeFree_CTD_human
Schizophrenia	0.12	1	1	GWASCAT
MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2	0.12	2	0	UNIPROT
Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome	0.12	1	0	CTD_human
melanoma	0.010616028	9	0	BeFree_LHGDN
Mammary Neoplasms	0.003267234	3	0	BeFree_LHGDN
ovarian neoplasm	0.002995792	1	0	BeFree_LHGDN
Cardiomegaly	0.00272435	1	0	LHGDN
Squamous cell carcinoma	0.00272435	1	0	LHGDN

AKT3 (AKT serine/threonine kinase 3)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

尚未收录相关数据

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

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