AKT2基因详情-基因数据库-基因云馆

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AKT2 (AKT serine/threonine kinase 2)

symbol:: AKT2
locus group:: protein-coding gene
location:: 19q13.2
gene_family:: Pleckstrin homology domain containing
alias symbol:: PKBβ
alias name:: None
entrez id:: 208
ensembl gene id:: ENSG00000105221
ucsc gene id:: uc002onf.3
refseq accession:: NM_001626
hgnc_id:: HGNC:392
approved reserved:: 1992-11-05

19q13.2

AKT2（也称为蛋白激酶Bβ）是AKT丝氨酸/苏氨酸激酶家族的重要成员，属于AGC激酶超家族。AKT家族包括AKT1、AKT2和AKT3三个亚型，它们在结构上高度相似，都含有PH结构域、激酶结构域和调控结构域，并通过PI3K信号通路被激活。AKT家族的主要功能是调控细胞存活、增殖、代谢和生长，尤其在胰岛素信号传导中发挥核心作用。AKT2在胰岛素敏感组织中（如肌肉、脂肪和肝脏）表达较高，主要负责调控葡萄糖代谢。它通过促进GLUT4转运到细胞膜上来增强葡萄糖摄取，并抑制糖异生，从而维持血糖平衡。AKT2的突变或功能异常与多种疾病密切相关，尤其是胰岛素抵抗和2型糖尿病。例如，AKT2的功能缺失突变会导致罕见的遗传性胰岛素抵抗综合征，表现为严重的高血糖和高胰岛素血症。此外，AKT2的异常激活与多种癌症（如乳腺癌、卵巢癌和胰腺癌）的发生发展有关，因为它能促进肿瘤细胞的存活和增殖。当AKT2过表达时，会增强细胞增殖和存活信号，可能导致肿瘤发生或加剧胰岛素抵抗；而AKT2表达降低则可能引起葡萄糖代谢紊乱，增加糖尿病风险。AKT2还与其他基因和通路相互作用，比如抑制FOXO转录因子、激活mTORC1，从而影响蛋白质合成和细胞生长。在癌症中，AKT2的过表达常伴随PTEN或PIK3CA的突变，进一步放大致癌信号。AKT家族成员的冗余功能使得单一亚型的缺失可能被其他亚型部分补偿，但AKT2在代谢调控中的独特作用使其成为糖尿病和癌症治疗的重要靶点。

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]

此基因是编码属于含有SH2结构状（Src同源2样）结构域的丝氨酸/苏氨酸激酶亚家族的蛋白质的推定的癌基因。该基因被示出被放大，并在2 8的卵巢癌细胞株和2 15的原发性卵巢肿瘤中过表达。过表达有助于人类胰腺导管癌的一个子集的恶性表型。所编码的蛋白质能够phophorylating几种已知的蛋白质的一般蛋白激酶。 [由RefSeq的，2008年7月提供]

OMIM数据库中对CCND1基因的介绍 Wikipedia数据库中对CCND1基因的介绍

CCND1基因的碱基序列：[NCBI]

Loading Gene Browser...

AKT2基因的碱基突变：仅显示部分snp

rs748236 rs873143 rs892118 rs892119 rs892120 rs969531 rs1138528 rs1991823 rs2288917 rs2304186 rs2304187 rs2304188 rs2304189 rs2356230 rs3730050 rs3730051 rs3730052

AKT2基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

TAGCCATTGTCCAGTTTAACC

GCAGAGCTAAGGAAACAAGG

GGTCCAGAAGAAGCTCCTG

TCATCTTGTGTCGACCTCG

GTCATCATTGCCAAGCTGG

GTCAGTGATCTTGATGTGGC

CATAGGCTAATGTCGAGGGA

TCTTTGTCCAGCATGAGGT

TTATCAGACCCTATGGGTGC

TAGAACCGACTTCACCGTC

GGTCCAGAAGAAGCTCCTG

GGTGTGATTGTGATGGACTG

CATGGACTACAAGTGTGGC

ATTCATGGTCACTTTAGCCC

CTAGGTGACAGCGTACCAC

GTCTTGATGTATTCACCACGC

ATGTTGTTTCTAAGGGCTGGA

AGGAGAATCGCTTGAACCC

TCATTGGGTACAAGGAGAGG

TTCATCAGCTGGCATTCTG

转录因子

影响基因

影响类型

参考文献链接（PubMed）

NFKB1

AKT2

Repression

20514445

PROX1

AKT2

Repression

22982861

RELA

AKT2

Repression

20514445

TWIST1

AKT2

Activation

21876555; 22982861

AKT2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

AKT2基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0004672

C9JHS6 (UniProtKB)

IEA

GO:0005524

C9JHS6 (UniProtKB)

IEA

GO:0006468

C9JHS6 (UniProtKB)

IEA

GO:0004674

J3QKW1 (UniProtKB)

IEA

GO:0005524

J3QKW1 (UniProtKB)

IEA

GO:0006468

J3QKW1 (UniProtKB)

IEA

GO:0004674

J3QL45 (UniProtKB)

IEA

GO:0005524

J3QL45 (UniProtKB)

IEA

GO:0006468

J3QL45 (UniProtKB)

IEA

GO:0004674

M0R0P9 (UniProtKB)

IEA

GO:0005524

M0R0P9 (UniProtKB)

IEA

GO:0006468

M0R0P9 (UniProtKB)

IEA

GO:0004672

M0R275 (UniProtKB)

IEA

GO:0005524

M0R275 (UniProtKB)

IEA

GO:0006468

M0R275 (UniProtKB)

IEA

GO:0004674

M0R283 (UniProtKB)

IEA

GO:0005524

M0R283 (UniProtKB)

IEA

GO:0006468

M0R283 (UniProtKB)

IEA

GO:0001934

P31751 (UniProtKB)

ISS

GO:0004674

P31751 (UniProtKB)

IDA

GO:0004674

P31751 (UniProtKB)

TAS

GO:0004674

P31751 (UniProtKB)

TAS

GO:0004674

P31751 (UniProtKB)

TAS

GO:0004674

P31751 (UniProtKB)

TAS

GO:0005080

P31751 (UniProtKB)

IEA

GO:0005515

P31751 (UniProtKB)

IPI

GO:0005515

P31751 (UniProtKB)

IPI

GO:0005515

P31751 (UniProtKB)

IPI

GO:0005515

P31751 (UniProtKB)

IPI

GO:0005515

P31751 (UniProtKB)

IPI

GO:0005515

P31751 (UniProtKB)

IPI

GO:0005515

P31751 (UniProtKB)

IPI

GO:0005515

P31751 (UniProtKB)

IPI

GO:0005515

P31751 (UniProtKB)

IPI

GO:0005515

P31751 (UniProtKB)

IPI

GO:0005515

P31751 (UniProtKB)

IPI

GO:0005524

P31751 (UniProtKB)

IDA

GO:0005634

P31751 (UniProtKB)

IDA

GO:0005634

P31751 (UniProtKB)

TAS

GO:0005654

P31751 (UniProtKB)

TAS

GO:0005769

P31751 (UniProtKB)

IEA

GO:0005829

P31751 (UniProtKB)

TAS

GO:0005829

P31751 (UniProtKB)

TAS

GO:0005829

P31751 (UniProtKB)

TAS

GO:0005829

P31751 (UniProtKB)

TAS

GO:0005886

P31751 (UniProtKB)

ISS

GO:0005886

P31751 (UniProtKB)

TAS

GO:0005938

P31751 (UniProtKB)

ISS

GO:0005978

P31751 (UniProtKB)

IEA

GO:0006006

P31751 (UniProtKB)

IEA

GO:0006417

P31751 (UniProtKB)

IEA

GO:0006464

P31751 (UniProtKB)

TAS

GO:0006970

P31751 (UniProtKB)

IEA

GO:0007165

P31751 (UniProtKB)

TAS

GO:0008286

P31751 (UniProtKB)

IMP

GO:0008286

P31751 (UniProtKB)

TAS

GO:0008643

P31751 (UniProtKB)

IEA

GO:0009967

P31751 (UniProtKB)

IEA

GO:0010748

P31751 (UniProtKB)

IMP

GO:0010907

P31751 (UniProtKB)

IMP

GO:0014850

P31751 (UniProtKB)

IEA

GO:0018105

P31751 (UniProtKB)

IBA

GO:0030334

P31751 (UniProtKB)

TAS

GO:0030335

P31751 (UniProtKB)

IEA

GO:0031340

P31751 (UniProtKB)

ISS

GO:0031667

P31751 (UniProtKB)

IEA

GO:0032000

P31751 (UniProtKB)

IMP

GO:0032287

P31751 (UniProtKB)

IEA

GO:0032587

P31751 (UniProtKB)

ISS

GO:0032593

P31751 (UniProtKB)

IEA

GO:0032869

P31751 (UniProtKB)

IMP

GO:0033119

P31751 (UniProtKB)

IEA

GO:0033138

P31751 (UniProtKB)

IEA

GO:0035556

P31751 (UniProtKB)

IBA

GO:0043154

P31751 (UniProtKB)

IEA

GO:0043491

P31751 (UniProtKB)

IEA

GO:0045429

P31751 (UniProtKB)

IEA

GO:0045444

P31751 (UniProtKB)

TAS

GO:0045725

P31751 (UniProtKB)

IMP

GO:0045944

P31751 (UniProtKB)

IEA

GO:0046326

P31751 (UniProtKB)

IMP

GO:0050927

P31751 (UniProtKB)

IEA

GO:0060644

P31751 (UniProtKB)

TAS

GO:0065002

P31751 (UniProtKB)

ISS

GO:0071156

P31751 (UniProtKB)

TAS

GO:0071407

P31751 (UniProtKB)

IEA

GO:0072659

P31751 (UniProtKB)

IEA

GO:0090314

P31751 (UniProtKB)

ISS

GO:0090630

P31751 (UniProtKB)

IEA

GO:2000147

P31751 (UniProtKB)

IMP

GO:2001275

P31751 (UniProtKB)

IEA

可能调控 AKT2基因的相关microRNA：

hsa-miR-124 hsa-let-7a hsa-let-7b hsa-let-7b* hsa-let-7c hsa-let-7c* hsa-let-7d hsa-let-7d* hsa-let-7e hsa-let-7e*

Reactome

MINT

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
4014 Ras signaling pathway [PATH:hsa04014]
4015 Rap1 signaling pathway [PATH:hsa04015]
4010 MAPK signaling pathway [PATH:hsa04010]
4012 ErbB signaling pathway [PATH:hsa04012]
4370 VEGF signaling pathway [PATH:hsa04370]
4630 Jak-STAT signaling pathway [PATH:hsa04630]
4668 TNF signaling pathway [PATH:hsa04668]
4066 HIF-1 signaling pathway [PATH:hsa04066]
4068 FoxO signaling pathway [PATH:hsa04068]
4071 Sphingolipid signaling pathway [PATH:hsa04071]
4024 cAMP signaling pathway [PATH:hsa04024]
4022 cGMP - PKG signaling pathway [PATH:hsa04022]
4151 PI3K-Akt signaling pathway [PATH:hsa04151]
4152 AMPK signaling pathway [PATH:hsa04152]
4150 mTOR signaling pathway [PATH:hsa04150]
4210 Apoptosis [PATH:hsa04210]
4510 Focal adhesion [PATH:hsa04510]
4530 Tight junction [PATH:hsa04530]
4550 Signaling pathways regulating pluripotency of stem cells [PATH:hsa04550]
4611 Platelet activation [PATH:hsa04611]
4620 Toll-like receptor signaling pathway [PATH:hsa04620]
4660 T cell receptor signaling pathway [PATH:hsa04660]
4662 B cell receptor signaling pathway [PATH:hsa04662]
4664 Fc epsilon RI signaling pathway [PATH:hsa04664]
4666 Fc gamma R-mediated phagocytosis [PATH:hsa04666]
4062 Chemokine signaling pathway [PATH:hsa04062]
4910 Insulin signaling pathway [PATH:hsa04910]
4922 Glucagon signaling pathway [PATH:hsa04922]
4920 Adipocytokine signaling pathway [PATH:hsa04920]
4915 Estrogen signaling pathway [PATH:hsa04915]
4914 Progesterone-mediated oocyte maturation [PATH:hsa04914]
4917 Prolactin signaling pathway [PATH:hsa04917]
4919 Thyroid hormone signaling pathway [PATH:hsa04919]
4261 Adrenergic signaling in cardiomyocytes [PATH:hsa04261]
4973 Carbohydrate digestion and absorption [PATH:hsa04973]
4725 Cholinergic synapse [PATH:hsa04725]
4728 Dopaminergic synapse [PATH:hsa04728]
4722 Neurotrophin signaling pathway [PATH:hsa04722]
4380 Osteoclast differentiation [PATH:hsa04380]
5200 Pathways in cancer [PATH:hsa05200]
5230 Central carbon metabolism in cancer [PATH:hsa05230]
5231 Choline metabolism in cancer [PATH:hsa05231]
5205 Proteoglycans in cancer [PATH:hsa05205]
5210 Colorectal cancer [PATH:hsa05210]
5212 Pancreatic cancer [PATH:hsa05212]
5214 Glioma [PATH:hsa05214]
5221 Acute myeloid leukemia [PATH:hsa05221]
5220 Chronic myeloid leukemia [PATH:hsa05220]
5218 Melanoma [PATH:hsa05218]
5211 Renal cell carcinoma [PATH:hsa05211]
5215 Prostate cancer [PATH:hsa05215]
5213 Endometrial cancer [PATH:hsa05213]
5222 Small cell lung cancer [PATH:hsa05222]
5223 Non-small cell lung cancer [PATH:hsa05223]
4932 Non-alcoholic fatty liver disease (NAFLD) [PATH:hsa04932]
5152 Tuberculosis [PATH:hsa05152]
5166 HTLV-I infection [PATH:hsa05166]
5162 Measles [PATH:hsa05162]
5164 Influenza A [PATH:hsa05164]
5161 Hepatitis B [PATH:hsa05161]
5160 Hepatitis C [PATH:hsa05160]
5169 Epstein-Barr virus infection [PATH:hsa05169]
5145 Toxoplasmosis [PATH:hsa05145]
5142 Chagas disease (American trypanosomiasis) [PATH:hsa05142]

名称
Activation of BAD and translocation to mitochondria
Activation of BH3-only proteins
Activation of PKB
Adaptive Immune System
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
AKT-mediated inactivation of FOXO1A
Apoptosis
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
Constitutive Signaling by AKT1 E17K in Cancer
Costimulation by the CD28 family
CTLA4 inhibitory signaling
DAP12 interactions
DAP12 signaling
deactivation of the beta-catenin transactivating complex
Developmental Biology
Disease
Diseases of signal transduction
Downregulation of ERBB2:ERBB3 signaling
Downstream signal transduction
Downstream signaling events of B Cell Receptor (BCR)
Downstream signaling of activated FGFR1
Downstream signaling of activated FGFR2
Downstream signaling of activated FGFR3
Downstream signaling of activated FGFR4
Fc epsilon receptor (FCERI) signaling
G beta:gamma signalling through PI3Kgamma
G-protein beta:gamma signalling
GAB1 signalosome
Gene Expression
Generic Transcription Pathway
GPCR downstream signaling
GPVI-mediated activation cascade
Hemostasis
IGF1R signaling cascade
Immune System
Inhibition of HSL
Inhibition of TSC complex formation by PKB
Innate Immune System
Insulin receptor signalling cascade
Intrinsic Pathway for Apoptosis
IRS-mediated signalling
IRS-related events
IRS-related events triggered by IGF1R
Membrane Trafficking
mTOR signalling
Negative regulation of the PI3K/AKT network
NGF signalling via TRKA from the plasma membrane
PDE3B signalling
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
PI3K Cascade
PI3K events in ERBB2 signaling
PI3K events in ERBB4 signaling
PI3K/AKT activation
PI3K/AKT Signaling in Cancer
PIP3 activates AKT signaling
PKB-mediated events
Platelet activation, signaling and aggregation
Programmed Cell Death
Regulation of beta-cell development
Regulation of gene expression in beta cells
Role of LAT2/NTAL/LAB on calcium mobilization
Signal Transduction
Signaling by EGFR
Signaling by ERBB2
Signaling by ERBB4
Signaling by FGFR
Signaling by FGFR1
Signaling by FGFR2
Signaling by FGFR3
Signaling by FGFR4
Signaling by GPCR
Signaling by Insulin receptor
Signaling by PDGF
Signaling by SCF-KIT
Signaling by the B Cell Receptor (BCR)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Signaling by VEGF
Signaling by Wnt
Signalling by NGF
TCF dependent signaling in response to WNT
TP53 Regulates Metabolic Genes
Transcriptional Regulation by TP53
Translocation of GLUT4 to the plasma membrane
VEGFA-VEGFR2 Pathway
VEGFR2 mediated vascular permeability
Vesicle-mediated transport

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Diabetes Mellitus, Non-Insulin-Dependent	0.440814326	4	1	BeFree_CLINVAR_CTD_human_MGD_UNIPROT
HYPOINSULINEMIC HYPOGLYCEMIA WITH HEMIHYPERTROPHY	0.24	1	0	ORPHANET_UNIPROT
Mammary Neoplasms	0.1254487	3	0	CTD_human_LHGDN
Nasopharyngeal carcinoma	0.12	1	0	CTD_human
Familial partial lipodystrophy	0.12	1	0	CTD_human
Glioma	0.087620235	9	0	BeFree_LHGDN_RGD
Liver carcinoma	0.083810118	6	0	BeFree_LHGDN_RGD
Polycystic Ovary Syndrome	0.083181358	3	0	BeFree_GAD_MGD
Obesity	0.080271442	2	0	BeFree_RGD
Myocardial Reperfusion Injury	0.08	1	0	RGD

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更新于2天前

AKT2 (AKT serine/threonine kinase 2)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

联系方式

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