ADCY3基因详情-基因数据库-基因云馆

登录系统

ADCY3 (adenylate cyclase 3)

symbol:: ADCY3
locus group:: protein-coding gene
location:: 2p23.3
gene_family:: Adenylate cyclases
alias symbol:: AC3
alias name:: None
entrez id:: 109
ensembl gene id:: ENSG00000138031
ucsc gene id:: uc002rfs.5
refseq accession:: NM_001320613
hgnc_id:: HGNC:234
approved reserved:: 1994-07-22

2p23.3

ADCY3（腺苷酸环化酶3）是一种重要的膜结合酶，属于腺苷酸环化酶（AC）基因家族，该家族共有9个成员（ADCY1-9）。腺苷酸环化酶家族的共性是将ATP转化为第二信使cAMP（环磷酸腺苷），从而参与多种细胞信号传导通路，调控包括代谢、细胞增殖、分化和基因表达在内的多种生理过程。ADCY3主要表达于大脑、脂肪组织和嗅觉上皮等部位，其生物学功能与嗅觉信号传导、能量代谢调节和神经元活动密切相关。在嗅觉系统中，ADCY3是嗅觉受体信号通路的关键组分，负责将气味分子激活的G蛋白偶联受体信号转化为cAMP信号，进而触发嗅觉神经元反应。在脂肪组织中，ADCY3通过调节cAMP水平影响脂肪分解和能量代谢，与肥胖和代谢综合征的发生发展相关。ADCY3的突变可能导致其功能异常，例如某些错义突变会降低酶活性，与肥胖风险增加有关，而另一些突变可能影响嗅觉功能，导致嗅觉障碍。研究发现ADCY3基因敲除小鼠表现出肥胖表型、嗅觉缺失以及葡萄糖代谢异常，表明该基因在能量平衡和感觉功能中的重要作用。ADCY3过表达可能增强cAMP信号通路活性，促进脂肪分解和能量消耗，但也可能导致信号通路过度激活引发异常细胞反应；而ADCY3表达降低则可能减少cAMP产生，抑制脂肪分解，促进脂肪堆积，增加肥胖风险。此外，ADCY3与多种疾病相关，包括肥胖症、2型糖尿病、嗅觉功能障碍以及某些神经系统疾病。在癌症中，ADCY3的表达异常可能影响肿瘤细胞的增殖和迁移。由于其在代谢和神经系统中的重要作用，ADCY3被认为是治疗代谢性疾病和某些神经疾病的潜在靶点。

This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. [provided by RefSeq, Jul 2008]

这个基因编码的腺苷酸环化酶3，其是一种膜相关酶和催化第二信使环磷酸腺苷（cAMP）的形成。这种蛋白质似乎在各种人组织进行广泛表达，并可能参与许多生理学和病理生理学的代谢过程。 [由RefSeq的，2008年7月提供]

OMIM数据库中对ADCY3基因的介绍 Wikipedia数据库中对ADCY3基因的介绍

ADCY3基因的碱基序列：[NCBI]

Loading Gene Browser...

ADCY3基因的碱基突变：仅显示部分snp

rs7945 rs753529 rs876186 rs916484 rs916485 rs916486 rs934608 rs934610 rs934611 rs1044040 rs1056074 rs1056075 rs1058064 rs1077640 rs1077641 rs1077642 rs1127568

ADCY3基因在不同组织中的表达： [UniProt]

正向引物序列

正向Tm值

反向引物序列

反向Tm值

评分

GACATGAAGAAAGACGAGAGC

AAGAGGATGCTGACGTTCTC

GTCCTACTACATGGCTGAC

AAAGCATGAGGTTCTCCTG

GGAATTTAGTTCTAGCTGATCAGTG

CTGAGGGCCTCTTCTTGTC

GAGCTGTACAGGCTAATGAC

ATCCAAGTTGAGAAGGCCA

CAACATTCAGTGGCGTCTG

TCTACCACCTGGAAACTGC

ATTGGCAGCACGTATATGG

GACTTGTCTTCCTTGTTGGAG

GACATGAAGAAAGACGAGAGC

AAGAGGATGCTGACGTTCTC

AGAGATGAGGAGCTGTATAGC

GTAGAAGTCAGCAAAGTTGGG

ATCATCTCCGTGGTCTCCT

AAAGCATGAGGTTCTCCTCC

CCACCATCAACCTCTATGC

CCATAGGTAAGTCGTGCTC

尚未收录相关数据

ADCY3基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

质膜
细胞质
细胞外
高尔基体
囊泡
细胞骨架
内质网
细胞核
内体
溶酶体
线粒体

ADCY3基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0000166

A0A0A0MSC1 (UniProtKB)

IEA

GO:0004016

A0A0A0MSC1 (UniProtKB)

IEA

GO:0005622

A0A0A0MSC1 (UniProtKB)

IEA

GO:0005886

A0A0A0MSC1 (UniProtKB)

IEA

GO:0006171

A0A0A0MSC1 (UniProtKB)

IEA

GO:0016021

A0A0A0MSC1 (UniProtKB)

IEA

GO:0035556

A0A0A0MSC1 (UniProtKB)

IEA

GO:0016021

C9J969 (UniProtKB)

IEA

GO:0000166

C9JLX3 (UniProtKB)

IEA

GO:0005622

C9JLX3 (UniProtKB)

IEA

GO:0009190

C9JLX3 (UniProtKB)

IEA

GO:0016021

C9JLX3 (UniProtKB)

IEA

GO:0016849

C9JLX3 (UniProtKB)

IEA

GO:0035556

C9JLX3 (UniProtKB)

IEA

GO:0005622

C9JYB5 (UniProtKB)

IEA

GO:0009190

C9JYB5 (UniProtKB)

IEA

GO:0016021

C9JYB5 (UniProtKB)

IEA

GO:0016849

C9JYB5 (UniProtKB)

IEA

GO:0035556

C9JYB5 (UniProtKB)

IEA

GO:0000166

H7C1A6 (UniProtKB)

IEA

GO:0005622

H7C1A6 (UniProtKB)

IEA

GO:0009190

H7C1A6 (UniProtKB)

IEA

GO:0016849

H7C1A6 (UniProtKB)

IEA

GO:0035556

H7C1A6 (UniProtKB)

IEA

GO:0016021

H7C1S5 (UniProtKB)

IEA

GO:0003091

O60266 (UniProtKB)

TAS

GO:0004016

O60266 (UniProtKB)

ISS

GO:0004016

O60266 (UniProtKB)

TAS

GO:0005516

O60266 (UniProtKB)

IEA

GO:0005524

O60266 (UniProtKB)

IEA

GO:0005634

O60266 (UniProtKB)

IEA

GO:0005737

O60266 (UniProtKB)

IDA

GO:0005794

O60266 (UniProtKB)

ISS

GO:0005886

O60266 (UniProtKB)

IDA

GO:0005886

O60266 (UniProtKB)

TAS

GO:0005886

O60266 (UniProtKB)

TAS

GO:0005886

O60266 (UniProtKB)

TAS

GO:0005886

O60266 (UniProtKB)

TAS

GO:0005886

O60266 (UniProtKB)

TAS

GO:0005886

O60266 (UniProtKB)

TAS

GO:0005886

O60266 (UniProtKB)

TAS

GO:0005886

O60266 (UniProtKB)

TAS

GO:0005886

O60266 (UniProtKB)

TAS

GO:0005886

O60266 (UniProtKB)

TAS

GO:0005886

O60266 (UniProtKB)

TAS

GO:0005886

O60266 (UniProtKB)

TAS

GO:0005886

O60266 (UniProtKB)

TAS

GO:0005887

O60266 (UniProtKB)

TAS

GO:0005929

O60266 (UniProtKB)

ISS

GO:0006171

O60266 (UniProtKB)

ISS

GO:0007143

O60266 (UniProtKB)

IEA

GO:0007165

O60266 (UniProtKB)

TAS

GO:0007189

O60266 (UniProtKB)

ISS

GO:0007189

O60266 (UniProtKB)

IBA

GO:0007189

O60266 (UniProtKB)

TAS

GO:0007190

O60266 (UniProtKB)

TAS

GO:0007193

O60266 (UniProtKB)

IBA

GO:0007193

O60266 (UniProtKB)

TAS

GO:0007338

O60266 (UniProtKB)

ISS

GO:0007340

O60266 (UniProtKB)

ISS

GO:0007608

O60266 (UniProtKB)

ISS

GO:0008294

O60266 (UniProtKB)

IEA

GO:0008355

O60266 (UniProtKB)

ISS

GO:0016020

O60266 (UniProtKB)

IDA

GO:0016021

O60266 (UniProtKB)

ISS

GO:0019933

O60266 (UniProtKB)

IBA

GO:0030317

O60266 (UniProtKB)

ISS

GO:0034199

O60266 (UniProtKB)

TAS

GO:0045121

O60266 (UniProtKB)

IEA

GO:0046872

O60266 (UniProtKB)

IEA

GO:0071377

O60266 (UniProtKB)

TAS

GO:1904322

O60266 (UniProtKB)

ISS

GO:0000166

U3KQ91 (UniProtKB)

IEA

GO:0005622

U3KQ91 (UniProtKB)

IEA

GO:0009190

U3KQ91 (UniProtKB)

IEA

GO:0016021

U3KQ91 (UniProtKB)

IEA

GO:0016849

U3KQ91 (UniProtKB)

IEA

GO:0035556

U3KQ91 (UniProtKB)

IEA

GO:0005622

U3KQR1 (UniProtKB)

IEA

GO:0009190

U3KQR1 (UniProtKB)

IEA

GO:0016849

U3KQR1 (UniProtKB)

IEA

GO:0035556

U3KQR1 (UniProtKB)

IEA

可能调控 ADCY3基因的相关microRNA：

hsa-miR-124 hsa-miR-1296 hsa-miR-1301 hsa-miR-877

Reactome

BioGrid

IntAct

mentha

String

序号	作用方式	资源库来源/分值	基因名称	基因名称

KEGG
Reactomepathway

名称
230 Purine metabolism [PATH:hsa00230]
4015 Rap1 signaling pathway [PATH:hsa04015]
4020 Calcium signaling pathway [PATH:hsa04020]
4024 cAMP signaling pathway [PATH:hsa04024]
4022 cGMP - PKG signaling pathway [PATH:hsa04022]
4114 Oocyte meiosis [PATH:hsa04114]
4540 Gap junction [PATH:hsa04540]
4611 Platelet activation [PATH:hsa04611]
4062 Chemokine signaling pathway [PATH:hsa04062]
4911 Insulin secretion [PATH:hsa04911]
4912 GnRH signaling pathway [PATH:hsa04912]
4913 Ovarian Steroidogenesis [PATH:hsa04913]
4915 Estrogen signaling pathway [PATH:hsa04915]
4914 Progesterone-mediated oocyte maturation [PATH:hsa04914]
4921 Oxytocin signaling pathway [PATH:hsa04921]
4918 Thyroid hormone synthesis [PATH:hsa04918]
4916 Melanogenesis [PATH:hsa04916]
4261 Adrenergic signaling in cardiomyocytes [PATH:hsa04261]
4270 Vascular smooth muscle contraction [PATH:hsa04270]
4970 Salivary secretion [PATH:hsa04970]
4971 Gastric acid secretion [PATH:hsa04971]
4972 Pancreatic secretion [PATH:hsa04972]
4976 Bile secretion [PATH:hsa04976]
4962 Vasopressin-regulated water reabsorption [PATH:hsa04962]
4724 Glutamatergic synapse [PATH:hsa04724]
4727 GABAergic synapse [PATH:hsa04727]
4725 Cholinergic synapse [PATH:hsa04725]
4723 Retrograde endocannabinoid signaling [PATH:hsa04723]
4740 Olfactory transduction [PATH:hsa04740]
4750 Inflammatory mediator regulation of TRP channels [PATH:hsa04750]
4713 Circadian entrainment [PATH:hsa04713]
5200 Pathways in cancer [PATH:hsa05200]
5032 Morphine addiction [PATH:hsa05032]
5414 Dilated cardiomyopathy (DCM) [PATH:hsa05414]
5110 Vibrio cholerae infection [PATH:hsa05110]
5166 HTLV-I infection [PATH:hsa05166]

名称
Activation of GABAB receptors
Activation of NMDA receptor upon glutamate binding and postsynaptic events
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
Aquaporin-mediated transport
Ca-dependent events
Calmodulin induced events
CaM pathway
CREB phosphorylation through the activation of Adenylate Cyclase
DAG and IP3 signaling
DAP12 interactions
DAP12 signaling
Downstream signal transduction
Downstream signaling of activated FGFR1
Downstream signaling of activated FGFR2
Downstream signaling of activated FGFR3
Downstream signaling of activated FGFR4
EGFR interacts with phospholipase C-gamma
G alpha (i) signalling events
G alpha (s) signalling events
G alpha (z) signalling events
G-protein mediated events
GABA B receptor activation
GABA receptor activation
Glucagon signaling in metabolic regulation
GPCR downstream signaling
Hedgehog 'off' state
Immune System
Inhibition of adenylate cyclase pathway
Innate Immune System
Integration of energy metabolism
Metabolism
Neuronal System
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
NGF signalling via TRKA from the plasma membrane
Opioid Signalling
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Phospholipase C-mediated cascade: FGFR1
PKA activation
PKA activation in glucagon signalling
PKA-mediated phosphorylation of CREB
PLC beta mediated events
PLC-gamma1 signalling
PLCG1 events in ERBB2 signaling
Post NMDA receptor activation events
Signal Transduction
Signaling by EGFR
Signaling by ERBB2
Signaling by FGFR
Signaling by FGFR1
Signaling by FGFR2
Signaling by FGFR3
Signaling by FGFR4
Signaling by GPCR
Signaling by Hedgehog
Signaling by PDGF
Signalling by NGF
Transmembrane transport of small molecules
Transmission across Chemical Synapses
Vasopressin regulates renal water homeostasis via Aquaporins

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Inflammatory Bowel Diseases	0.120271442	2	1	BeFree_GWASCAT
Olfaction Disorders	0.08	1	0	RGD
Female infertility	0.08	1	0	RGD
Obesity	0.002909916	2	0	BeFree_GAD
Diabetes Mellitus, Non-Insulin-Dependent	0.002638474	1	0	BeFree_GAD
Alcoholic Intoxication, Chronic	0.002367032	1	0	GAD
Overweight	0.000271442	1	0	BeFree
Major Depressive Disorder	0.000271442	1	2	BeFree
Carcinogenesis	0.000271442	1	0	BeFree
Malignant neoplasm of stomach	0.000271442	1	0	BeFree

联系方式

山东省济南市章丘区文博路2号齐鲁师范学院 genelibs生信实验室

山东省济南市高新区舜华路750号大学科技园北区F座4单元2楼

电话： 0531-88819269

E-mail: product@genelibs.com

微信公众号

关注微信订阅号，实时查看信息，关注医学生物学动态。

更新于2天前

ADCY3 (adenylate cyclase 3)

基因基本信息

基因基本信息

基因染色体位置

基因染色体位置

基因简述

基因简述

基因序列

基因序列

基因突变

基因突变

基因表达

基因表达

基因引物

基因引物

转录因子

转录因子

尚未收录相关数据

基因本体信息

基因相关microRNA

基因相关microRNA

基因相互作用关系

基因相互作用关系

基因通路

基因通路

基因相关疾病

基因相关疾病

基因相关服务

基因相关服务

联系方式

微信公众号