ACRBP (acrosin binding protein)
- symbol:
- ACRBP
- locus group:
- protein-coding gene
- location:
- 12p13.31
- gene_family:
- alias symbol:
- SP32|OY-TES-1|CT23
- alias name:
- proacrosin binding protein sp32|ca…
- entrez id:
- 84519
- ensembl gene id:
- ENSG00000111644
- ucsc gene id:
- uc001qpu.2
- refseq accession:
- NM_032489
- hgnc_id:
- HGNC:17195
- approved reserved:
- 2001-11-19
The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008]
由该基因编码的蛋白质类似proacrosin在小鼠中发现结合蛋白前体SP32，豚鼠和猪。该蛋白位于精子顶体并且被认为以用作结合蛋白proacrosin在顶体基质的顶体酶原的包装和冷凝。这种蛋白质是癌症/睾丸抗原族的一员，它被发现是免疫原性的。在正常组织中，该mRNA表达仅在睾丸，而它是在一个范围内的不同的肿瘤类型，如膀胱癌，乳腺癌，肺癌，肝癌和结肠癌的检测。 [由RefSeq的，2008年7月提供]
基因本体信息
ACRBP基因（以及对应的蛋白质）的细胞分布位置：
- 质膜
- 细胞质
- 细胞外
- 高尔基体
- 囊泡
- 细胞骨架
- 内质网
- 细胞核
- 内体
- 溶酶体
- 线粒体
ACRBP基因的本体（GO）信息：
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Prostatic Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Juvenile arthritis | 0.12 | 1 | 0 | CTD_human |
| Malignant neoplasm of testis | 0.000814326 | 3 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
| Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| ovarian neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
微信公众号
关注微信订阅号，实时查看信息，关注医学生物学动态。
版权所有 © 2025.Genelibs 济南弘晖生物技术有限公司 鲁ICP备13024435号-2
