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Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]
[中文简述(自动翻译):]  脑信号是一个大家族,包括分泌和膜相关蛋白,其中许多已被暗示为在轴突寻路,颤和分支,以及目标选择抑制剂或chemorepellents。所有脑信号具有一个脑信号蛋白(Sema结构)结构域和PSI结构域在N-末端胞外部分(在丛蛋白,脑信号蛋白和整联找到)。另外的序列基序的C-末端到脑信号蛋白域允许分类成不同的亚家族。结果表明,跨膜信号蛋白,如分泌的人,可以作为排斥轴突导向线索。该基因编码的一类脊椎动物6跨膜信号蛋白,演示了选择性剪接。几个转录变异体已经鉴定和不同编码同种型的表达被认为以组织和发展依赖的方式进行调节。 [由RefSeq的,2010年11月提供]
SEMA6D基因(以及对应的蛋白质)的细胞分布位置:
SEMA6D基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Substance-Related Disorders | 0.12 | 1 | 0 | CTD_human |
| Inflammatory Bowel Diseases | 0.002367032 | 1 | 1 | GAD |
| Kidney Failure, Chronic | 0.000271442 | 1 | 2 | BeFree |
| Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Kidney Failure | 0.000271442 | 1 | 2 | BeFree |
| Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
| Malignant Pleural Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
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