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This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009]
[中文简述(自动翻译):]  此基因编码一种维生素K依赖性血浆蛋白,其功能,作为抗凝血剂蛋白酶的辅因子,活化的蛋白C(APC),以抑制血液凝固。它在血浆中都一个自由的,功能活性形式也与C4b的结合蛋白复合非活性形式找到。突变这个基因导致常染色体显性遗传性血栓形成倾向。该位点的非活性假位于相邻区域上[由RefSeq的,2009年2月提供] 3号染色体
PROS1基因(以及对应的蛋白质)的细胞分布位置:
PROS1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL DOMINANT | 0.24 | 23 | 9 | CTD_human_UNIPROT |
| THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL RECESSIVE | 0.24 | 1 | 2 | CLINVAR_UNIPROT |
| Thrombosis | 0.127815732 | 4 | 0 | CTD_human_GAD_LHGDN |
| Activated Protein C Resistance | 0.127815732 | 4 | 0 | CTD_human_GAD_LHGDN |
| Thromboembolism | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| IGA Glomerulonephritis | 0.12 | 1 | 0 | CTD_human |
| Sagittal Sinus Thrombosis | 0.12 | 1 | 0 | CTD_human |
| Juvenile arthritis | 0.12 | 1 | 0 | CTD_human |
| Liver Cirrhosis, Experimental | 0.08 | 1 | 0 | RGD |
| Malignant neoplasm of prostate | 0.058360002 | 215 | 1 | BeFree |
| Prostate carcinoma | 0.058360002 | 215 | 1 | BeFree |
| Protein S Deficiency | 0.02969036 | 27 | 1 | BeFree_GAD_LHGDN |
| Venous Thrombosis | 0.017641179 | 6 | 0 | GAD_LHGDN |
| Neoplasm Metastasis | 0.007328931 | 27 | 0 | BeFree |
| Cardiovascular Diseases | 0.005091382 | 2 | 0 | GAD_LHGDN |
| Prostatic Neoplasms | 0.00408156 | 6 | 0 | BeFree_LHGDN |
| Benign Prostatic Hyperplasia | 0.004071628 | 15 | 0 | BeFree |
| Deep Vein Thrombosis | 0.003452799 | 5 | 0 | BeFree_GAD |
| Thrombophilia | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Respiratory Tract Infections | 0.00272435 | 1 | 0 | LHGDN |
| Uremia | 0.00272435 | 1 | 0 | LHGDN |
| Venous Thromboembolism | 0.00272435 | 1 | 0 | LHGDN |
| Infection | 0.00272435 | 1 | 0 | LHGDN |
| Coronary heart disease | 0.002638474 | 1 | 0 | BeFree_GAD |
| Hereditary protein S deficiency | 0.002442977 | 9 | 0 | BeFree |
| Abortion, Habitual | 0.002367032 | 1 | 0 | GAD |
| Carotid Stenosis | 0.002367032 | 1 | 0 | GAD |
| Chorioamnionitis | 0.002367032 | 1 | 0 | GAD |
| Fetal Membranes, Premature Rupture | 0.002367032 | 1 | 0 | GAD |
| Inflammation | 0.002367032 | 1 | 0 | GAD |
| Premature Obstetric Labor | 0.002367032 | 1 | 0 | GAD |
| Pre-Eclampsia | 0.002367032 | 1 | 0 | GAD |
| Cerebrovascular accident | 0.002367032 | 1 | 0 | GAD |
| Premature Birth | 0.002367032 | 1 | 0 | GAD |
| Pregnancy loss | 0.002367032 | 1 | 0 | GAD |
| Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 0.002367032 | 1 | 0 | GAD |
| Tumor Progression | 0.001628651 | 6 | 0 | BeFree |
| Adenocarcinoma of prostate | 0.001357209 | 5 | 0 | BeFree |
| Hormone refractory prostate cancer | 0.001357209 | 5 | 0 | BeFree |
| Salivary Gland Pleomorphic Adenoma | 0.001357209 | 5 | 0 | BeFree |
| Adenocarcinoma | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of breast | 0.001085767 | 4 | 0 | BeFree |
| Prostatic Diseases | 0.001085767 | 4 | 0 | BeFree |
| Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| androgen independent prostate cancer | 0.001085767 | 4 | 0 | BeFree |
| Prostate cancer recurrent | 0.000814326 | 3 | 0 | BeFree |
| Deep vein thrombosis of lower limb | 0.000814326 | 3 | 0 | BeFree |
| Secondary malignant neoplasm of lymph node | 0.000814326 | 3 | 0 | BeFree |
| Colitis | 0.000542884 | 2 | 0 | BeFree |
| Herpes Simplex Infections | 0.000542884 | 2 | 0 | BeFree |
| Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
| Tumor Immunity | 0.000542884 | 2 | 0 | BeFree |
| Prostate cancer, familial | 0.000542884 | 2 | 0 | BeFree |
| Anaplasia | 0.000271442 | 1 | 0 | BeFree |
| Anxiety Disorders | 0.000271442 | 1 | 0 | BeFree |
| Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
| Epilepsy | 0.000271442 | 1 | 0 | BeFree |
| Psoriasis | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Embolism | 0.000271442 | 1 | 0 | BeFree |
| Urinary tract infection | 0.000271442 | 1 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
| Deep thrombophlebitis | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of tongue | 0.000271442 | 1 | 0 | BeFree |
| Hereditary pancreatitis | 0.000271442 | 1 | 0 | BeFree |
| Psoriasis vulgaris | 0.000271442 | 1 | 0 | BeFree |
| Disorder of soft tissue | 0.000271442 | 1 | 0 | BeFree |
| Idiopathic generalized epilepsy | 0.000271442 | 1 | 0 | BeFree |
| Erythroblastosis | 0.000271442 | 1 | 0 | BeFree |
| Cancer of Head and Neck | 0.000271442 | 1 | 0 | BeFree |
| Prostatic Intraepithelial Neoplasias | 0.000271442 | 1 | 0 | BeFree |
| Oncocytoma, renal | 0.000271442 | 1 | 0 | BeFree |
| Tongue Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Renal thrombosis | 0.000271442 | 1 | 0 | BeFree |
| ovarian neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Chromophobe Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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