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The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
[中文简述(自动翻译):]  由该基因编码的蛋白刺激的几个转录因子和核受体,包括雌激素受体α,核呼吸因子1,和糖皮质激素受体的活性。所编码的蛋白质可能参与了脂肪氧化,非氧化的葡萄糖代谢,和能量消耗的调节。这种蛋白质在前驱糖尿病和2型糖尿病患者的下调。在该基因的某些等位基因变异增加肥胖发展的风险。已发现该基因编码不同亚型三个抄本变形。 [由RefSeq的,2010年3月提供]
PPARGC1B基因(以及对应的蛋白质)的细胞分布位置:
PPARGC1B基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Obesity | 0.125081451 | 10 | 0 | BeFree_CTD_human_GAD |
| Mammary Neoplasms | 0.12272435 | 2 | 0 | CTD_human_LHGDN |
| Hyperlipidemia | 0.12 | 1 | 0 | CTD_human |
| Sepsis | 0.08 | 1 | 0 | RGD |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.010901282 | 16 | 0 | BeFree_GAD |
| Malignant neoplasm of breast | 0.004267125 | 7 | 2 | BeFree_GAD |
| Diabetes Mellitus | 0.003724241 | 6 | 0 | BeFree_GAD |
| Cardiomyopathies | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Malignant neoplasm of prostate | 0.002909916 | 2 | 0 | BeFree_GAD |
| Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
| Alzheimer's Disease | 0.002367032 | 1 | 0 | GAD |
| Narcolepsy | 0.002367032 | 1 | 0 | GAD |
| Breast Carcinoma | 0.001900093 | 7 | 2 | BeFree |
| Diabetes | 0.001357209 | 5 | 0 | BeFree |
| Heart failure | 0.001357209 | 5 | 0 | BeFree |
| Congestive heart failure | 0.001357209 | 5 | 0 | BeFree |
| Hypertensive disease | 0.000542884 | 2 | 0 | BeFree |
| Muscular Atrophy | 0.000542884 | 2 | 0 | BeFree |
| Ankylosing spondylitis | 0.000542884 | 2 | 4 | BeFree |
| Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
| Asthma | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Cholelithiasis | 0.000271442 | 1 | 0 | BeFree |
| Colonic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
| Kidney Failure, Acute | 0.000271442 | 1 | 0 | BeFree |
| melanoma | 0.000271442 | 1 | 0 | BeFree |
| Musculoskeletal Diseases | 0.000271442 | 1 | 0 | BeFree |
| Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
| Chagas Disease | 0.000271442 | 1 | 0 | BeFree |
| Atrophy, Disuse | 0.000271442 | 1 | 0 | BeFree |
| Fasting Hypoglycemia | 0.000271442 | 1 | 0 | BeFree |
| Breast Cancer, Familial | 0.000271442 | 1 | 0 | BeFree |
| Non-alcoholic Fatty Liver Disease | 0.000271442 | 1 | 0 | BeFree |
| Sleep Apnea, Obstructive | 0.000271442 | 1 | 1 | BeFree |
| Metabolic Syndrome X | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cholesterol gallstones | 0.000271442 | 1 | 0 | BeFree |
| Cholecystolithiasis | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
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