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This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
[中文简述(自动翻译):]  该基因编码的蛋白质的沉默调节蛋白家族中的一员,其同源酵母Sir2的蛋白质。沉默调节蛋白家族成员的特征在于沉默调节核心结构域和分组为四个类。人类沉默调节蛋白的功能尚未确定;然而,酵母蛋白质的sirtuin已知表观遗传调控基因沉默和压抑的rDNA重组。研究表明,人类可能乙酰化酶功能的单ADP核糖基转移酶的活性细胞内调控蛋白。由该基因编码的蛋白质包含在沉默调节蛋白家族的I类。几个转录变体是由于该基因的选择性剪接。 [由RefSeq的,2010年7月提供]
SIRT2基因(以及对应的蛋白质)的细胞分布位置:
SIRT2基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Glioma | 0.086534468 | 5 | 0 | BeFree_LHGDN_RGD |
| Intermittent Claudication | 0.08 | 1 | 0 | RGD |
| Non-alcoholic Fatty Liver Disease | 0.08 | 1 | 0 | RGD |
| Parkinson Disease | 0.00272435 | 1 | 0 | LHGDN |
| Carcinogenesis | 0.001357209 | 5 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Neurodegenerative Disorders | 0.000814326 | 3 | 0 | BeFree |
| Anemia, Pernicious | 0.000542884 | 2 | 0 | BeFree |
| Rheumatoid Arthritis | 0.000542884 | 2 | 0 | BeFree |
| Asthma | 0.000542884 | 2 | 0 | BeFree |
| Diabetes | 0.000542884 | 2 | 0 | BeFree |
| Diabetes Mellitus | 0.000542884 | 2 | 0 | BeFree |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.000542884 | 2 | 0 | BeFree |
| Huntington Disease | 0.000542884 | 2 | 0 | BeFree |
| Hypothyroidism | 0.000542884 | 2 | 0 | BeFree |
| Lupus Erythematosus, Systemic | 0.000542884 | 2 | 0 | BeFree |
| Obesity | 0.000542884 | 2 | 0 | BeFree |
| Sarcoidosis | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
| Granulomatosis | 0.000542884 | 2 | 0 | BeFree |
| Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Hashimoto Disease | 0.000542884 | 2 | 0 | BeFree |
| Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Amyotrophic Lateral Sclerosis | 0.000271442 | 1 | 0 | BeFree |
| Bacterial Infections | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
| Female Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Rectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of skin | 0.000271442 | 1 | 0 | BeFree |
| Cardiovascular Diseases | 0.000271442 | 1 | 0 | BeFree |
| Celiac Disease | 0.000271442 | 1 | 0 | BeFree |
| Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
| Primary biliary cirrhosis | 0.000271442 | 1 | 0 | BeFree |
| Chondrosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Congenital chromosomal disease | 0.000271442 | 1 | 0 | BeFree |
| Ulcerative Colitis | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Mental Depression | 0.000271442 | 1 | 1 | BeFree |
| Depressive disorder | 0.000271442 | 1 | 1 | BeFree |
| Diabetes Mellitus, Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
| Endocrine Gland Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Graves Disease | 0.000271442 | 1 | 0 | BeFree |
| Hodgkin Disease | 0.000271442 | 1 | 0 | BeFree |
| leiomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| leukemia | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
| Chronic Obstructive Airway Disease | 0.000271442 | 1 | 2 | BeFree |
| Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
| Multiple Myeloma | 0.000271442 | 1 | 0 | BeFree |
| Nervous System Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Ovarian Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Parathyroid Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Polymyalgia Rheumatica | 0.000271442 | 1 | 0 | BeFree |
| Psoriasis | 0.000271442 | 1 | 0 | BeFree |
| Rett Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Rhabdomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Localized scleroderma | 0.000271442 | 1 | 0 | BeFree |
| Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
| Shy-Drager Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Ankylosing spondylitis | 0.000271442 | 1 | 0 | BeFree |
| synovial sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Giant Cell Arteritis | 0.000271442 | 1 | 0 | BeFree |
| Lymphoma, T-Cell, Cutaneous | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of gallbladder | 0.000271442 | 1 | 0 | BeFree |
| Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
| childhood soft tissue sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Premature aging syndrome | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of female breast | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of male breast | 0.000271442 | 1 | 0 | BeFree |
| Systemic Inflammatory Response Syndrome | 0.000271442 | 1 | 0 | BeFree |
| Muscular Dystrophy, Oculopharyngeal | 0.000271442 | 1 | 0 | BeFree |
| Cervix carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Multiple System Atrophy | 0.000271442 | 1 | 0 | BeFree |
| Mood Disorders | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of kidney | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of ovary | 0.000271442 | 1 | 0 | BeFree |
| Sarcoma | 0.000271442 | 1 | 0 | BeFree |
| Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Cancer Cell Growth | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
| Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Disturbance in mood | 0.000271442 | 1 | 0 | BeFree |
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