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Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors, which is a GTPase that plays a role at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA . Its role in the regulation of normal mitochondrial function and in disease states attributed to mitochondrial dysfunction is not known. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
[中文简述(自动翻译):]  真核生物含有两种蛋白质的平移系统,一个在细胞质中,一个在线粒体中。线粒体翻译是在呼吸链氧化磷酸化系统和受损维护线粒体DNA的维持线粒体功能和突变在本系统中导致击穿至关重要。该基因编码的线粒体翻译延伸因子,它是通过从信使RNA介导的核糖体的拆卸起着在线粒体翻译终止的一个角色的GTP酶之一。其在正常的线粒体功能的调节和归因于线粒体功能障碍的疾病状态的作用是未知的。在多个转录剪接变异体结果不同编码的亚型。 [由RefSeq的,2013年7月提供]
GFM2基因(以及对应的蛋白质)的细胞分布位置:
GFM2基因的本体(GO)信息:
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