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A loss of function variant in SLC30A8/ZnT8 drives proteomic changes associated …

Gasser(M),Cherkaoui(I),Ostinelli(G),Ferron(M… medRxiv 2026-04-20

...CRISPR/Cas9-derived heterozygous or homozygous R138X lines were differentiated into stem cell-derived islet-like cluster...

Citrate Transporter NaCT and Enamel Mineralization: The Slc13a5R337* Mouse Mode…

Smith(CE),Simmer(JP),Liang(T),Hu(Y),Animasah… Int J Mol Sci 2026-08-09

...CRISPR/Cas9 genome editing to generate Slc13a5R337* knock-in mice that terminate NaCT translation at the Arg337 codon, w...

Role of Hypoxia-Inducible Factor-1α in Regulating Muscle Degeneration After Rot…

Zhang(H),Lee(A),Liu(M),Diaz(A),Zhang(Y),Kim(… Am J Sports Med 2026-08-12

...CRISPR-Cas9 or prolyl hydroxylase domain inhibitors to evaluate FAP cell differentiation. TTDN induced significant capil...

Comparative genomic analysis of Streptococcus parasuis and Streptococcus suis r…

Zhen(Z),Baihe(M),Meiliang(G),Yuxuan(W),Lianr… Comp Immunol Microbiol Infect… 2026-08-25

...CRISPR spacer matching evidence, suggesting prior exposure to the relevant sequence space. None of the genomes met our p...

Modulation of Oncogenic NOTCH Signaling in Highly Aggressive Malignancies by Ta…

Martínez-Gascueña(P),Nueda(ML),Baladrón(V) Cells 2026-03-05

...CRISPR, CAR-T cells, and bispecific antibodies, as well as targeted delivery systems to enhance efficacy and reduce toxi...

Loss of the Coronary Artery Disease Risk Gene Leiomodin1 in Vascular Smooth Mus…

Salem(AR),Doja(J),Ge(C),Wally(A),Slivano(OJ)… bioRxiv 2026-02-17

...CRISPR). Control ( Lmod1 WT ) and VSMC-restricted Lmod1 knockout ( Lmod1 SMKO ) mice were subjected to various atherogen...

Causal circuit tracing reveals distinct computational architectures in single-c…

Kendiukhov(I) Bioinformatics 2026-07-02

...CRISPRi sign-bias-corrected excess than indirect pairs. Gene-level CRISPRi validation on Replogle K562 and the noncancer...

[Regulation of SARM1 on SNPH expression and its participation in glaucomatous o…

Zhang(XJ),Wu(JH) Zhonghua Yan Ke Za Zhi 2026-07-11

...CRISPR/Cas9 technology was used to knock down the expression of SARM1 and SNPH in mouse 661W retinal ganglion cells, res...

Grasping Molecular Biology Mechanisms to Optimize Plant Resistance and Advance …

Abd-Elgawad(MMM) Int J Mol Sci 2026-02-11

...CRISPR/Cas9 system has been effective in knocking out both the OsHPP04 gene in rice to confer resistance against Meloido...

Non-invasive radiogenomic mapping of the SMARCAL1-driven ferroptotic niche is a…

Huang(Z),He(J),Li(Y),Xu(Z),Peng(H),Gao(X),Zh… Front Immunol None

...CRISPR-Cas9 knockout of SMARCAL1 with wild-type and helicase-dead rescue in A549/H1299 cell lines, and primary human CXC...

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