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Generation of Ucp1-ires-Cre knock-in mice to enhance specificity and efficien...

Hsu(JY),Lu(WH),Chang(YY),Chiang(PC),King(P... Am J Physiol Endocrinol Met... 2026-05-01

...CRISPR-Cas9 to insert an ires-Cre sequence downstream of the UCP1 stop codon, developing the novel knock-in line, Ucp1-C...

Autophagy inhibition enhances PD-1 blockade efficacy in mismatch repair-profi...

Peng(W),Yang(ZR),Wang(Z),Zhao(YL),Tan(SS) Cancer Genet 2026-06-00

...CRISPR/Cas9 to delete the mismatch repair gene Mlh1 in CT26 colorectal cancer cells, generating CT26-dMMR cells. The par...

Influence of gRNA efficiency and inversion size on the frequency of CRISPR/Ca...

Grubben(J),Bijsterbosch(G),Visser(RGF),Sch... BMC Plant Biol 2026-03-10

...CRISPR)-Cas9 enables induction of chromosomal inversions from hundreds of base pairs to millions of base pairs, but the ...

[Construction and teaching practice of an AI- and OBE-integrated smart course...

Zou(Q),Ma(X),Sun(L),Chen(Z),Xiao(W),Huo(Y)... Sheng Wu Gong Cheng Xue Bao 2026-03-25

...CRISPR-Cas9, difficulties in transferring theoretical knowledge to experimental design, fragmentation of teaching resour...

Development and clinical validation of a CRISPR/Cas9-engineered reporter phag...

Hao(Z),Zhao(Q),Zhong(Y),Li(M),Wang(C),Wang(C) Microbiol Spectr 2026-08-06

...CRISPR/Cas9 system combined with homologous recombination. One-step growth curves, optimal multiplicity of infection, an...

Role of HIF-1α-SERPINE1 axis in hypoxia-induced trophoblast invasion and its ...

Zhang(Y),Dong(H),Wang(S),Zhang(F),Zhang(B) Tissue Cell 2026-07-27

...CRISPR/Cas9-generated SERPINE1 knockout (KO) mouse model was used to assess pregnancy outcomes with WT controls included...

SREBP-driven lipogenesis coupled with ferroptosis resistance as a therapeutic...

Hayata(Y),Matsushita(Y),Tempaku(M),Nakagaw... JHEP Rep 2026-08-29

...CRISPR-Cas9-engineered models, exhibited increased vulnerability to GPX4 inhibition. Furthermore, clinical eCCA samples ...

Oncogenic PIK3CA mutation enhances tumor immunogenicity through the IRF1-NLRC...

Su(YL),Huang(SY),Kuo(CW),Xiao(LY),Lin(CT),... J Immunother Cancer 2026-07-07

...CRISPR/Cas9-mediated knockout syngeneic murine models treated with anti-PD-L1 to assess tumor growth, immune infiltratio...

Co-Option and Conflict: The Deep Evolutionary History of ZP-Domain Proteins f...

Bezborodkina(N),Smutin(D),Adonin(L) Int J Mol Sci 2026-06-29

...CRISPR-based models are needed to resolve these questions.

Sleeping Beauty mutagenesis identifies BACH2 and other regulators of CD8+ T-c...

Lee(CJ),Larsson(AT),Jubenville(TA),Hudson(... J Immunother Cancer 2026-07-15

...CRISPR knockout screens have identified key genes enhancing T-cell persistence, employing Sleeping Beauty (SB) insertion...

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