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Tumor-intrinsic PD-L1 drives lung cancer progression in response to TLR stimu...

Sung(Y),Lee(HJ),Kim(MJ),Shin(JH),Kim(JY),K... Exp Hematol Oncol 2026-02-16

...CRISPR-Cas9-mediated knockout and plasmid-driven overexpression of PD-L1 were conducted in H460 and A549 cell lines to a...

SREBP-driven lipogenesis coupled with ferroptosis resistance as a therapeutic...

Hayata(Y),Matsushita(Y),Tempaku(M),Nakagaw... JHEP Rep 2026-08-29

...CRISPR-Cas9-engineered models, exhibited increased vulnerability to GPX4 inhibition. Furthermore, clinical eCCA samples ...

Profilin-1 Deficiency Activates STING to Drive T Cell-Mediated Anti-Tumor Imm...

Eder(I),Baghaei(M),Maurya(S),Yu(V),Wilson(... bioRxiv 2026-06-10

...CRISPR/Cas9 knockout (KO) model to first demonstrate that triggering Pfn1 depletion in breast cancer cells leads to feat...

Glucose transport dependency defines a therapeutic vulnerability in JAK2V617F...

Weiand(P),Chatain(N),de Toledo(MAS),Moellm... Cell Commun Signal 2026-06-23

...CRISPR-Cas9 was used to generate Slc2a1 (GLUT1) and Slc2a3 (GLUT3) knockout clones, which were subsequently characterize...

The cholesterol transporter Niemann-Pick C1 facilitates the entry of porcine ...

Li(S),Luo(H),Zhang(K),Wu(C),Jiang(Y),Zhou(... J Virol 2026-07-21

...CRISPR/Cas9 to knock out NPC1 in Huh7 cells, which significantly inhibited PEDV infection. Conversely, forced expression...

Co-Option and Conflict: The Deep Evolutionary History of ZP-Domain Proteins f...

Bezborodkina(N),Smutin(D),Adonin(L) Int J Mol Sci 2026-06-29

...CRISPR-based models are needed to resolve these questions.

Sleeping Beauty mutagenesis identifies BACH2 and other regulators of CD8+ T-c...

Lee(CJ),Larsson(AT),Jubenville(TA),Hudson(... J Immunother Cancer 2026-07-15

...CRISPR knockout screens have identified key genes enhancing T-cell persistence, employing Sleeping Beauty (SB) insertion...

Insight into the role of Sho1 in high-hydrostatic pressure and oxidative stre...

Lai(H),Hu(G),Cui(Y),Yu(X) Appl Environ Microbiol 2026-08-19

...CRISPR-Cas9 technology, we constructed a sho1 gene knockout mutant to examine its phenotypic and molecular responses to ...

Engineered Escherichia coli Nissle 1917 secreting anti-TNF-α nanobody as a si...

Zhu(Q),Feng(S),Yan(Z),Wang(Z),Huang(X),Sun... Front Immunol None

...CRISPR-Cas9-mediated chromosomal integration strategies were compared. Structural modeling and molecular dynamics simula...

TBC1D23-AAVR Interaction Drives Endosome-to-TGN Trafficking Required for rAAV...

Zhang(X),Habib(A),McFarlin(S),Richart(D),P... bioRxiv 2026-06-03

...CRISPR-mediated knockout of TBC1D23 severely impairs rAAV transduction across multiple human cell types, including polar...

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