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Partitioning RS domain phosphorylation in an SR protein through the CLK and S...

Aubol(Brandon E),Plocinik(Ryan M),Hagopian... J Mol Biol 2013-10-01

...SRSF1 is regulated by multisite phosphorylation of a long Arg-Ser repeat in the N-terminus of the RS domain while subnuc...

Identification of alternative splicing events regulated by the oncogenic fact...

de Miguel(Fernando J),Sharma(Ravi D),Pajar... Cancer Res 2014-04-22

...SRSF1). Data were generated using two different microarray platforms. The PCR-based validation rate of the top 20 ranked...

Nuclear Speckle-related Protein 70 Binds to Serine/Arginine-rich Splicing Fac...

Kim(Chang-Hyun),Kim(Young-Dae),Choi(Eun-Ky... J Biol Chem 2016-08-08

...SRSF1 or ASF/SF2) and SRSF2 (SC35). NSrp70 mediates alternative splice site selection, targeting several pre-mRNAs, incl...

SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorige...

Fu(Yu),Huang(Binlu),Shi(Zhen),Han(Jiayu),W... EMBO Mol Med 2013-11-04

...SRSF1 and SRSF9 promote β-catenin accumulation via the recruitment of β-catenin mRNA and by enhancing its translation in...

Identification of a chemical inhibitor for nuclear speckle formation: implica...

Kurogi(Yutaro),Matsuo(Yota),Mihara(Yuki),Y... Biochem Biophys Res Commun 2014-06-07

...SRSF1/SF2 from nuclear speckles in HeLa cells. Treatment with tubercidin also decreased steady-state MALAT1 long ncRNA, ...

Isolated pseudo-RNA-recognition motifs of SR proteins can regulate splicing u...

Cléry(Antoine),Sinha(Rahul),Anczuków(Olga)... Proc Natl Acad Sci U S A 2013-10-17

...SRSF1 pseudo-RRM bound to RNA, we discovered a very unusual and sequence-specific RNA-binding mode that is centered on o...

Directional Phosphorylation and Nuclear Transport of the Splicing Factor SRSF...

Serrano(Pedro),Aubol(Brandon E),Keshwani(M... J Mol Biol 0000-00-00

...SRSF1, we showed that several residues in the RNA-binding motif 2 interact with the N-terminal region of the RS domain (...

LncRNA-splicing factor condensates regulate hypoxia-responsive pre-mRNA proce...

Song(YJ),Shinn(MK),Bangru(S),Wang(Y),Sun(Q... Mol Cell 2026-03-19

...SRSF1) and pre-mRNAs. Mechanistically, MALAT1 promotes the condensation of SRSF1, and the condensates are preferentially...

Abnormal expression of the pre-mRNA splicing regulators SRSF1, SRSF2, SRPK1 a...

Gout(Stephanie),Brambilla(Elisabeth),Boudr... PLoS One 2013-04-02

...SRSF1 and SRSF2 are overexpressed in 63% and 65% of lung adenocarcinoma (ADC) as well as in 68% and 91% of squamous cell...

Phosphorylation mechanism and structure of serine-arginine protein kinases.

Ghosh(Gourisankar),Adams(Joseph A) FEBS J 2011-03-11

...SRSF1)], a prototype for the SR protein family, is regiospecifically phosphorylated by SRPK1, a post-translational modif...

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