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Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial ...

Opel(Aaisha),Nobles(Muriel),Montaigne(Davi... J Biol Chem 2015-10-19

...RGS4 (RGS4(-/-)) and the normal littermate controls (RGS4(+/+)). In vivo electrophysiology using atrial burst pacing rev...

A regulator of G protein signalling (RGS) protein confers agonist-dependent r...

Fujita(S),Inanobe(A),Chachin(M),Aizawa(Y),... J Physiol 2000-09-18

...RGS4, it became dependent on [ACh] when RGS4 was co-expressed. 3. Kinetic analyses indicated that RGS4 confers to the KG...

Intrathecal RGS4 inhibitor, CCG50014, reduces nociceptive responses and enhan...

Yoon(Seo-Yeon),Woo(Jiwan),Park(Joon-Oh),Ch... Anesth Analg 2015-04-15

...RGS4 affected nociceptive responses in the formalin pain test, (2) this RGS4-mediated effect was involved in OR activati...

Breast cancer migration and invasion depend on proteasome degradation of regu...

Xie(Yan),Wolff(Dennis W),Wei(Taotao),Wang(... Cancer Res 2009-09-25

...RGS4 disrupted Rac1-dependent lamellipodia formation, a key step involved in cancer migration and invasion. RGS4 has GTP...

RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) mo...

Wydeven(Nicole),Posokhova(Ekaterina),Xia(Z... J Biol Chem 2014-03-26

...RGS4 and RGS6-Gβ5 have been implicated in these processes. Here, we used Rgs4(-/-), Rgs6(-/-), and Rgs4(-/-):Rgs6(-/-) m...

The role of regulator of G protein signaling 4 in delta-opioid receptor-media...

Dripps(Isaac J),Wang(Qin),Neubig(Richard R... Psychopharmacology (Berl) 0000-00-00

...RGS4 knockout mice in the forced swim test but not in the tail suspension test. Additionally, RGS4 knockout did not alte...

Regulator of G protein signaling 4 confers selectivity to specific G proteins...

Leontiadis(Leonidas J),Papakonstantinou(Ma... Cell Signal 2009-06-03

...RGS4. RGS4 is recruited to the plasma membrane upon opioid receptor stimulation. Expression of RGS4 in HEK293 cells atte...

Regulators of G-protein signaling (RGS) 4, insertion into model membranes and...

Ouyang(Ying-Shi),Tu(Yaping),Barker(Sheryll... J Biol Chem 2003-05-02

...RGS4 to accelerate GTPase activity in vitro. Phosphatidic acid is an effective and potent inhibitor of RGS4 in a G alpha...

MEKK1-MKK4-JNK-AP1 pathway negatively regulates Rgs4 expression in colonic sm...

Zhang(Yonggang),Li(Fang),Liu(Shu),Wang(Hon... PLoS One 2012-08-27

...Rgs4 in response to IL-1β. Mutation of the AP1-binding site within Rgs4 promoter increased the promoter activity. Wester...

Role of regulators of g-protein signaling 4 in ca signaling in mouse pancreat...

Park(Soonhong),Lee(Syng-Ill),Shin(Dong Min... Korean J Physiol Pharmacol 2012-10-02

...RGS4(-/-) mice. RGS4(-/-) acinar cells showed an enhanced stimulus intensity response to a muscarinic receptor agonist i...

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