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Additional sex combs-like 2 is required for polycomb repressive complex 2 bin...

Lai(Hsiao-Lei),Wang(Q Tian) PLoS One 2014-06-15

...ASXL2 target genes in the heart and investigate the mechanism by which ASXL2 facilitates their repression. We show that ...

Reciprocal regulation of LXRα activity by ASXL1 and ASXL2 in lipogenesis.

Park(Ui-Hyun),Seong(Mi-ran),Kim(Eun-Joo),H... Biochem Biophys Res Commun 2014-03-10

...ASXL2 in regulating LXRα activity. We found that ASXL1 suppressed ligand-induced LXRα transcriptional activity, whereas ...

WTIP interacts with ASXL2 and blocks ASXL2-mediated activation of retinoic ac...

Khan(Farida F),Li(Yanyang),Balyan(Arjun),W... Biochem Biophys Res Commun 2014-12-08

...ASXL2 and WTIP. In HeLa cells, ASXL2 enhances retinoic acid-dependent luciferase activity, while WTIP represses it. Furt...

Clinical significance of ESR1 gene copy number changes in breast cancer as me...

Lin(Ching-Hung),Liu(Jacqueline M),Lu(Yen-S... J Clin Pathol 2013-03-22

...ASXL2 as a reference.,FISH revealed ESR1 amplification in six cases (4.0%) and ESR1 gain in 13 cases (8.7%) from a total...

Functional and cancer genomics of ASXL family members.

Katoh(M) Br J Cancer 2013-10-17

...ASXL2 occur in prostate cancer, pancreatic cancer and breast cancer and those of ASXL3 are observed in melanoma. EPC1-AS...

Maintenance of adult cardiac function requires the chromatin factor Asxl2.

Lai(Hsiao-Lei),Grachoff(Milana),McGinley(A... J Mol Cell Cardiol 2013-03-22

...Asxl2 is highly expressed in the murine heart both during development and adulthood. In the absence of Asxl2, there is a...

The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigenetics.

Abdel-Wahab(O),Dey(A) Leukemia 2013-02-28

...ASXL2, but the functional importance of this interaction has remained elusive. Here, we highlight recent work revealing ...

Loss of the tumor suppressor BAP1 causes myeloid transformation.

Dey(Anwesha),Seshasayee(Dhaya),Noubade(Raj... Science 2012-10-09

...ASXL2 in vivo. OGT and HCF-1 levels were decreased by Bap1 deletion, indicating a critical role for BAP1 in stabilizing ...

The HARE-HTH and associated domains: novel modules in the coordination of epi...

Aravind(L),Iyer(Lakshminarayan M) Cell Cycle 2012-09-18

...ASXL2) and the Bohring-Opitz syndrome, a developmental disorder (ASXL1). Using sensitive sequence and structure comparis...

Mouse genome-wide association and systems genetics identify Asxl2 as a regula...

Farber(Charles R),Bennett(Brian J),Orozco(... PLoS Genet 2011-08-18

...Asxl2) gene that was predicted to be functional. The involvement of Asxl2 in the regulation of bone mass was confirmed b...

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