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NFKBIZ mediates neuroprotection and maintains blood-brain barrier integrity in …

Huang(C),Mo(X),Liu(Y),Hu(D),Li(C),Zhao(Y),Wa… Exp Neurol 2026-04-00

...NFKBIZ activity. Our findings indicate that NFKBIZ is essential for maintaining BBB integrity. Overexpression of NFKBIZ ...

NFKBIZ and CW6 in Adalimumab Response Among Psoriasis Patients: Genetic Associa…

Coto-Segura(P),González-Lara(L),Batalla(A),E… Mol Diagn Ther 2019-00-00

...NFKBIZ alternative transcript in patients with a positive versus negative response. We genotyped a common NFKBIZ polymor...

IL-17 Cytokines Induce IκBζ in Dermal Fibroblasts to Promote Pro-Inflammatory G…

Svraka(L),Andersen(AS),Touborg(T),Emmanuel(T… Int J Mol Sci 2026-01-28

...NFKBIZ regulation in human dermal fibroblasts in vitro and integrates spatial transcriptomics to determine NFKBIZ expres...

Linalool targets NR3C2 to inhibit NF-κB-mediated gastric cancer progression.

Hu(Y),Chen(S),Wang(Y),Liu(L),Zhang(C),Chen(H… Cell Div 2026-05-18

...NFKBIZ and inhibited NF-κB signaling, and restoring NFKBIZ expression reversed GC progression caused by NR3C2 deficiency...

Regulation of lymphoid-myeloid lineage bias through regnase-1/3-mediated contro…

Uehata(T),Yamada(S),Ori(D),Vandenbon(A),Gila… Blood 2024-00-18

...Nfkbiz. Consistently, an antisense oligonucleotide designed to inhibit Reg1- and Reg3-mediated Nfkbiz mRNA degradation p...

IκBζ controls NLRP3 inflammasome activation via upregulation of the Nlrp3 gene.

Kim(J),Ahn(H),Yu(S),Ahn(JH),Ko(HJ),Kweon(MN)… Cytokine 2020-00-00

...Nfkbiz gene depletion mice presented a defect in NLRP3 inflammasome activation. In addition, the Nfkbiz+/- and Nfkbiz-/-...

NFKBIZ in Psoriasis: Assessing the association with gene polymorphisms and repo…

Coto-Segura(P),Gonzalez-Lara(L),Gómez(J),Eir… Hum Immunol 2017-00-00

The IκBζ protein (NFKBIZ gene) is a nuclear inhibitor of NF-κB and plays an important role in the pathogenesis of Psoria...

Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis.

Kakiuchi(N),Yoshida(K),Uchino(M),Kihara(T),A… Nature 2020-00-00

...Nfkbiz-mutant mice and cell competition was compromised by disruption of NFKBIZ in human colorectal cancer cells. Our re...

IκBζ is essential for natural killer cell activation in response to IL-12 and I…

Miyake(T),Satoh(T),Kato(H),Matsushita(K),Kum… Proc Natl Acad Sci U S A 2010-10-12

...Nfkbiz(-/-) NK cells. Acetylation of histone 3 K9 on Ifng regions was also abrogated in Nfkbiz(-/-) NK cells. IκBζ was r...

Epithelial Regnase-1 inhibits colorectal tumor growth by regulating IL-17 signa…

Iguchi(E),Takai(A),Oe(N),Fujii(Y),Omatsu(M),… Proc Natl Acad Sci U S A 2025-06-10

...Nfkbiz knockout mouse model demonstrated that the tumor-suppressive effect of Regnase-1 depended on Nfkbiz expression. R...

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