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Emerging evidence on micro- and nanoplastics carcinogenicity: mechanisms, mod...

Alaraby(M),Abass(D),Marcos(R),Hernández(A) Mol Cancer 2026-04-02

...TP53, caspases, and XIAP, activating apoptosis, necroptosis, and fibrosis. Compensatory antioxidant responses are activa...

Mutant p53 Directs PARP to Regulate Replication Stress and Drive Breast Cance...

Xiao(G),Annor(GK),Harmon(KW),Chavez(V),Lev... bioRxiv 2026-03-28

...tp53 mediates mtp53-PARP and mtp53-Poly (ADP-ribose) (PAR) interactions that facilitate S phase progression [4, 5]. The ...

Pan-cancer proteogenomic interrogation of the Ubiquitin Proteasome System.

González-Robles(TJ),Khan(M),Sastourné(P),T... bioRxiv 2026-05-10

...TP53 loss) produce coherent UPS protein-quantitative trait locus (pQTL) signatures. Two case studies (UBR5 and TRIM28) i...

Isoform-Specific Functions of p73 Drive Survival and Chemoresistance in Diffu...

Hassan(HM),Varney(ML),Weisenburger(DD),Sin... bioRxiv 2026-03-27

...TP53 family member located on chromosome 1p36, encodes both transcriptionally active (TAp73) and dominant-negative (ΔNp7...

Pembrolizumab for high TMB castration-resistant prostate cancer: A precision ...

Terrano(V),Perri(E),Cioffo(C),Mastroianni(... Int Cancer Conf J 2026-04-00

...TP53. Due to the high TMB, off-label Pembrolizumab was initiated. Radiological evaluations at 3 and 6 months showed a ma...

Mechanistic overview and suggested strategies to overcome BCL-2 inhibitor res...

Iqbal(U),Shallis(RM) Front Cell Dev Biol None

...TP53-mutated AML based on clinical outcomes comparable to other available standards of care. However, TP53-mutated AML i...

Results and Exploratory Biomarker Analyses of a Phase II Study CHANGEABLE: Co...

Zhang(J),Du(Y),Meng(Y),Jin(Y),Lin(M),Shao(... MedComm (2020) 2026-04-00

...TP53 mutations significantly correlated with shorter PFS, while ASXL1 mutations correlated with longer PFS. This chemoth...

Isocitrate Dehydrogenase-Mutant Astrocytomas: Risk Stratification and Therape...

Wei(S),Xu(X),Bao(J),Pan(Z) MedComm (2020) 2026-04-00

...TP53) and by later events linked to malignant transformation (e.g., CDKN2A/B homozygous deletion). Despite integrated gr...

Measurement of mitochondria amount and clearance using flow cytometry: effect...

Kořánová(T),Grebeňová(D),Kuželová(K) Cancer Metab 2026-04-03

...TP53, as well as the adherent cell line HS-5. RESULTS: Repeated analyses confirmed high sensitivity and reproducibility ...

The role of germline mutations in non-small cell lung cancer: A systematic re...

Gentile(G),Gelibter(A),De Marchis(L),Pappa... Crit Rev Oncol Hematol 2026-07-00

...TP53, PALB2, CHEK2, and EGFR. Prevalence rates varied by gene, cohort characteristics, ethnicity, and histology with spe...

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