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Integrated Network Pharmacology and Molecular Docking Uncover Multi-Target Ac...

Nazeer(AA),Al-Sabri(AE),Sorrori(SN),Arif(I... Int J Mol Sci 2026-02-07

...TP53, CASP8, and EGFR were identified using protein-protein interaction (PPI) network analysis. Analysis of gene-disease...

Exome-Wide Association Analysis Identifies Rare Germline Susceptibility Varia...

Bu(R),Iqbal(K),Parvathareddy(SK),Azam(S),Q... Int J Mol Sci 2026-02-11

...TP53 (4.9% vs. 0.36%; OR = 14.3; p = 5.39 × 10-8) demonstrated strong associations. Sequence Kernel Association Test (SK...

Naringin Alleviates Knee Osteoarthritis by Targeting TNF-α and PTGS2: An Inte...

Zhou(H),Zhou(J),Lu(Y),Luo(H),Hu(W),Xie(J),... Int J Mol Sci 2026-02-13

...TP53, CASP3, and PPARG were recognized as core targets. Functional enrichment indicated these targets were primarily ass...

FOXM1 Signaling Network Transcriptionally Upregulates Expression of Proteins ...

Rida(P),Andreae(R),Bikhazi(N),Jackson(B),W... Int J Mol Sci 2026-02-14

...TP53 mutations. These features fuel therapy resistance, metastases, and poor clinical outcomes. An integrated framework ...

Chronic lymphocytic leukemia with IGH/BCL2 fusion and clonal heterogeneity: p...

Zhang(T),Liu(D),Ren(F),Hao(J),Ye(F),Chen(Y... Ann Hematol 2026-02-11

...TP53, KMT2A, KMT2C, and KMT2D gave rise to two distinct subclones: one (CD5 + CD23+CD200+) CLL driven by mutations in TN...

Concurrent Germline-Somatic Alterations and Associations with Cancer Outcomes...

Pal(LR),Schäffer(AA),Avila(S),Wooten(J),Bu... Res Sq 2026-02-02

...TP53 and germline BRCA1/somatic TP53 (n=40 and n=38 studies, respectively). Statistical testing was performed in 41.6% (...

HDAC1-modified lamin A/C drives nuclear deformation in RB1-deficient lung ade...

Li(H),Chen(Y),Wei(L),Wu(P),Fang(F),Li(F),L... Lung Cancer 2026-04-00

...TP53 and RB1 exhibited enhanced tumor invasion characteristics and a poor clinical prognosis. Our findings demonstrated ...

A novel approach to defining progression in MDS and precursor myeloid conditi...

DeZern(AE),Gillis(N),Otterstatter(M),Abel(... Blood Adv 2026-04-28

...TP53 mutation, and poor/very poor cytogenetic score. Based on these prospective data, guidelines for clinical management...

Prognostic Model Combining Mutational and Cytogenetic Profiles in Acute Myelo...

Drekolias(D),Tuz Zahra(F),Fileni(C),Sallma... Blood Cancer Discov 2026-05-05

...TP53, KRAS, JAK2, U2AF1, CBL, and cytogenetic lesions del(7q)/-7, del(17p)/-17/i(17q), del(20q), and MECOM rearrangement...

Genomic landscape of stage 0-IA lung adenocarcinoma identified by on-site ref...

Ilié(M),Heeke(S),Rignol(G),Pirlog(R),Goffi... Lung Cancer 2026-03-00

...TP53 mutations. Significant associations were observed between genomic alterations, histologic subtypes, and tumor grade...

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