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When loss is gain: truncating mutations in additional sex combs (ASXL) gene f...

Nakamura(Y),Nguyen(T),Mor(N),Torio(CJ),Thu... Trends Genet 2026-07-00

...ASXL2, and ASXL3, first described as the additional sex combs (Asx) in Drosophila. The encoded proteins scaffold BAP1-me...

BAP1 dysregulation impairs trophoblast differentiation and contributes to pla...

Doria-Borrell(P),Ferrero-Micó(A),Navarro-S... Cell Death Dis 2026-03-26

...ASXL2 and ASXL3 as upregulated in EO-PE placentas. Enforced BAP1 expression in human trophoblast stem cells reinforced e...

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2-EZH2-Mediated Microtub...

Yin(J),Zhang(M),Liu(W),Shen(W),Li(D),Miao(... Adv Sci (Weinh) 2026-05-00

...ASXL2)-enhancer of zeste homolog 2 (EZH2) axis. Hypoxia downregulates ASXL2 expression, which reduces EZH2 binding to th...

Phosphorylation of a Tumor-Derived ASXL2 Epitope Remodels the HLA-Bound Pepti...

Zhang(J),Lv(L),Chen(B),Yi(X) Comput Struct Biotechnol J None

...ASXL2)-derived epitope supported by confident tandem mass spectrometry-based phosphosite localization and detected acros...

Neonatal muscle-derived extracellular vesicles containing miR-542-3p rejuvena...

Yuan(F),Chen(Y),Li(W),Zhang(L),Du(R),Xu(S)... Bioact Mater 2026-11-00

...Asxl2-PPARγ, leading to reduced lipid accumulation. At the same time, it suppressed Eef1a1 to activate the AMPK pathway,...

Integrating genomic features for prognosis in Chinese patients with diffuse l...

Han(S),Zhou(L),Zheng(H),Zhao(Y),Cai(Z),He(... Ann Hematol 2026-06-03

...ASXL2 (HR = 2.20; P = 0.048) were significantly associated with poor PFS. A five-gene mutation risk score combined with ...

Assessing Pubertal Timing, Duration, and Related Characteristics in ASXL-Rela...

Piring(A),Hicks(R),Sloan(J),Ramires-Sanche... Am J Med Genet A 2026-01-00

...ASXL2), or Bainbridge-Ropers syndrome (BRS) (ASXL3). Our findings showed evidence for parental and perceived provider co...

ASXL2 Modulates Chromatin Remodeling to Direct Osteogenesis and Multiple Cell...

Yang(T),Zhou(Y),Han(R),Hu(M),Zeng(B),Shi(H... Int Dent J 2025-10-00

...ASXL2 emerges as a pivotal epigenetic target for craniofacial regeneration. Strategic modulation of ASXL2 activity may o...

Shashi-Pena syndrome with late-onset specific hypogammaglobinaemia and autoim...

Al Ali(A),Saidalani(A),Yeganeh(M),Russell(... BMJ Case Rep 2025-08-04

...ASXL2 gene, presented with a spectrum of manifestations. These encompassed intellectual disability, severe scoliosis, un...

Unconventional structure and function of PHD domains from additional sex comb...

Reddington(CJ),Walsh(AR),Kleffmann(T),Göbl... FEBS J 2025-12-00

...ASXL2 PHD and MBD6 MBD domains, and is required for stable complex formation. Overall, these data suggest an unconventio...

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