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PMID: 9973271 Published · ppublish English Journal Article Review

Biological implications of the DNA structures associated with disease-causing triplet repeats.

American journal of human genetics ·Vol. 64 ·No. 2 ·1999-02-00 ·Pages 346-53

Sinden RR

Abstract

暂无摘要

MeSH Terms
Animals DNA/chemistry DNA-Binding Proteins/metabolism Humans Neurodegenerative Diseases/genetics Nucleic Acid Conformation Nucleic Acid Heteroduplexes Trinucleotide Repeat Expansion Trinucleotide Repeats
Chemicals
DNA-Binding Proteins Nucleic Acid Heteroduplexes DNA
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Sinden R R
Center for Genome Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX 77030-3303, USA. rsinden@ibtmail. tamu.edu
References (27)
27 references, click to expand
  1. DNA structure, mutations, and human genetic disease.
    Curr Opin Biotechnol. 1992 Dec;3(6):612-22 PMID: 1369117
  2. On the deletion of inverted repeated DNA in Escherichia coli: effects of length, thermal stability, and cruciform formation in vivo.
    Genetics. 1991 Dec;129(4):991-1005 PMID: 1783300
  3. Preferential DNA secondary structure mutagenesis in the lagging strand of replication in E. coli.
    Nature. 1991 Aug 8;352(6335):544-7 PMID: 1865910
  4. Pausing in simian virus 40 DNA replication by a sequence containing (dG-dA)27.(dT-dC)27.
    Nucleic Acids Res. 1988 Aug 25;16(16):8077-94 PMID: 2843810
  5. Unusual sequence element found at the end of an amplicon.
    Mol Cell Biol. 1987 Jul;7(7):2636-40 PMID: 3039353
  6. Effect of myotonic dystrophy trinucleotide repeat expansion on DMPK transcription and processing.
    Genomics. 1995 Jul 1;28(1):1-14 PMID: 7590731
  7. Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli.
    Nat Genet. 1995 Jun;10(2):213-8 PMID: 7663518
  8. Expanded CTG triplet blocks from the myotonic dystrophy gene create the strongest known natural nucleosome positioning elements.
    Genomics. 1995 Jan 20;25(2):570-3 PMID: 7789994
  9. Alternative structures in duplex DNA formed within the trinucleotide repeats of the myotonic dystrophy and fragile X loci.
    Biochemistry. 1996 Apr 16;35(15):5041-53 PMID: 8664297
  10. Nucleosome assembly on methylated CGG triplet repeats in the fragile X mental retardation gene 1 promoter.
    J Biol Chem. 1996 Oct 4;271(40):24325-8 PMID: 8798682
  11. Long CCG triplet repeat blocks exclude nucleosomes: a possible mechanism for the nature of fragile sites in chromosomes.
    J Mol Biol. 1996 Nov 8;263(4):511-6 PMID: 8918933
  12. Mechanisms of triplex-caused polymerization arrest.
    Nucleic Acids Res. 1997 Apr 1;25(7):1339-46 PMID: 9060427
  13. Trinucleotide repeats associated with human disease.
    Nucleic Acids Res. 1997 Jun 15;25(12):2245-54 PMID: 9171073
  14. Flexible DNA: genetically unstable CTG.CAG and CGG.CCG from human hereditary neuromuscular disease genes.
    J Biol Chem. 1997 Jul 4;272(27):16783-92 PMID: 9201983
  15. Hairpin formation during DNA synthesis primer realignment in vitro in triplet repeat sequences from human hereditary disease genes.
    J Biol Chem. 1997 Jul 4;272(27):16798-806 PMID: 9201985
  16. Human MSH2 binds to trinucleotide repeat DNA structures associated with neurodegenerative diseases.
    Hum Mol Genet. 1997 Jul;6(7):1117-23 PMID: 9215683
  17. Trinucleotide repeats affect DNA replication in vivo.
    Nat Genet. 1997 Nov;17(3):298-304 PMID: 9354793
  18. The GAA triplet-repeat expansion in Friedreich ataxia interferes with transcription and may be associated with an unusual DNA structure.
    Am J Hum Genet. 1998 Jan;62(1):111-21 PMID: 9443873
  19. Structural analysis of slipped-strand DNA (S-DNA) formed in (CTG)n. (CAG)n repeats from the myotonic dystrophy locus.
    Nucleic Acids Res. 1998 Feb 1;26(3):816-23 PMID: 9443975
  20. Secondary structures in d(CGG) and d(CCG) repeat tracts.
    J Mol Biol. 1998 Jan 9;275(1):3-16 PMID: 9451434
  21. CTG repeats associated with human genetic disease are inherently flexible.
    J Mol Biol. 1998 Jan 23;275(3):405-11 PMID: 9466918
  22. Inhibitory effects of expanded GAA.TTC triplet repeats from intron I of the Friedreich ataxia gene on transcription and replication in vivo.
    J Biol Chem. 1998 Jun 5;273(23):14588-95 PMID: 9603975
  23. Expansion of CTG repeats from human disease genes is dependent upon replication mechanisms in Escherichia coli: the effect of long patch mismatch repair revisited.
    J Mol Biol. 1998 Jun 26;279(5):1101-10 PMID: 9642087
  24. NGG-triplet repeats form similar intrastrand structures: implications for the triplet expansion diseases.
    Nucleic Acids Res. 1998 Sep 1;26(17):4078-85 PMID: 9705522
  25. Transcriptional properties of RNA polymerase II within triplet repeat-containing DNA from the human myotonic dystrophy and fragile X loci.
    J Biol Chem. 1998 Oct 9;273(41):26998-7008 PMID: 9756950
  26. Flexing DNA: HMG-box proteins and their partners.
    Am J Hum Genet. 1998 Dec;63(6):1573-7 PMID: 9837808
  27. Myotonic dystrophy: the role of RNA CUG triplet repeats.
    Am J Hum Genet. 1999 Feb;64(2):360-4 PMID: 9973273
Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
DOI
10.1086/302271
Published
1999-02-00
Pages
346-53
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1377743
Subset
IM
External Links
PubMed source DOI: 10.1086/302271 PMC Full Text View journal details
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