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PMID: 9878611 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems.

Virology ·Vol. 252 ·No. 2 ·1998-12-20 ·Pages 324-30

García-Sastre A, Egorov A, Matassov D, Brandt S, Levy DE, Durbin JE, Palese P, Muster T

Abstract

The NS1 protein is the only nonstructural protein encoded by influenza A virus. It has been proposed that the NS1 performs several regulatory functions during the viral replication cycle, including the regulation of synthesis, transport, splicing, and translation of mRNAs. Through the use of reverse genetics, a viable transfectant influenza A virus (delNS1) which lacks the NS1 gene has been generated. Our results indicate that the NS1 of influenza A virus is an auxiliary (virulence) factor which plays a crucial role in inhibiting interferon-mediated antiviral responses of the host.

MeSH Terms
Animals Cell Line Chick Embryo Chlorocebus aethiops DNA-Binding Proteins/genetics,physiology Dogs Gene Deletion Influenza A virus/genetics,physiology Kidney Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Orthomyxoviridae Infections/genetics,physiopathology STAT1 Transcription Factor Signal Transduction Trans-Activators/genetics,physiology Transfection Vero Cells Viral Nonstructural Proteins/genetics,metabolism Virus Replication
Chemicals
DNA-Binding Proteins INS1 protein, influenza virus STAT1 Transcription Factor Stat1 protein, mouse Trans-Activators Viral Nonstructural Proteins
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
García-Sastre A
Department of Microbiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York, 10029, USA.
Egorov A
Matassov D
Brandt S
Levy D E
Durbin J E
Palese P
Muster T
Article Info
Journal
Virology
Abbr.
Virology
ISSN
0042-6822
DOI
10.1006/viro.1998.9508
Published
1998-12-20
Pages
324-30
Language
English
Region
United States
NLM ID
0110674
Subset
IM
External Links
PubMed source DOI: 10.1006/viro.1998.9508 View journal details
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