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题目:: Normal epithelial cells modulating HLA class I surface molecules are susceptible to lysis mediated by CD3(+) and CD3(-) "nonspecific" killer cells.
作者:: Semino(C),Pietra(G),Semino(A),Falco(M),Varaldo(M),Melioli(G)
状态:: 发布时间1999-02-02 , 更新时间 2004-11-17
期刊:: Cell Immunol
摘要:: Natural killer (NK) cells and NK-like T cells have been described as efficiently lysing neoplastic cells derived from hematopoietic tumors. By modulating the expression of HLA class I surface molecules on normal epithelial cells, we also observed that nonneoplastic cells can efficiently be lysed by "nonspecific" effectors. Clonal analysis clearly demonstrates that the presence of HLA-specific inhibitory NK receptors, such as CD94, CD158a, and CD158b, described on NK cells, is responsible for the inhibitory signal. Thus, NK cells, as well as NK-like T cells, in the absence of HLA surface molecules on normal target cells, efficiently lyse epithelial cells.
语言:: eng
DOI:: 10.1006/cimm.1998.1392

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