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PMID: 9874813 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Diversity and molecular evolution of the RPS2 resistance gene in Arabidopsis thaliana.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 96 ·No. 1 ·1999-01-05 ·Pages 302-6

Caicedo AL, Schaal BA, Kunkel BN

Abstract

The RPS2 gene in Arabidopsis thaliana governs resistance to strains of the bacterial pathogen, Pseudomonas syringae pv. tomato, that express the avrRpt2 gene. The two loci are involved in a gene-for-gene interaction. Seventeen accessions of A. thaliana were sequenced to explore the diversity present in the coding region of the RPS2 locus. An unusually high level of nucleotide polymorphisms was found (1.26%), with nearly half of the observed polymorphisms resulting in amino acid changes in the RPS2 protein. Seven haplotypes (alleles) were identified and their evolutionary relationships deduced. Several of the alleles conferring resistance were found to be closely related, whereas susceptibility to disease was conferred by widely divergent alleles. The possibility of selection at the RPS2 locus is discussed.

MeSH Terms
Arabidopsis/genetics Arabidopsis Proteins Evolution, Molecular Genes, Plant Genetic Variation Haplotypes Plant Diseases/genetics Plant Proteins/genetics Pseudomonas Selection, Genetic Sequence Analysis, DNA
Chemicals
Arabidopsis Proteins Plant Proteins RPS2 protein, Arabidopsis
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Caicedo A L
Department of Biology, Washington University, St. Louis, MO 63130, USA. alcaiced@artsci.wustl.edu
Schaal B A
Kunkel B N
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.96.1.302
Email
alcaiced@artsci.wustl.edu
Published
1999-01-05
Pages
302-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC15134
Subset
IM
Grants
NIGMS NIH HHS · GM52536 · United States
External Links
PubMed source DOI: 10.1073/pnas.96.1.302 PMC Full Text View journal details
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