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Inhibitors of mammalian G1 cyclin-dependent kinases.
Genes Dev. 1995 May 15;9(10):1149-63
PMID: 7758941
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A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer.
Nat Genet. 1995 Jan;9(1):70-4
PMID: 7704028
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Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27.
Science. 1995 Aug 4;269(5224):682-5
PMID: 7624798
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Translational control of p27Kip1 accumulation during the cell cycle.
Science. 1996 Mar 29;271(5257):1861-4
PMID: 8596954
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p27/Kip1 mutation found in breast cancer.
Cancer Res. 1996 May 15;56(10):2400-4
PMID: 8625318
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Inactivation of p27Kip1 by the viral E1A oncoprotein in TGFbeta-treated cells.
Nature. 1996 Mar 21;380(6571):262-5
PMID: 8637577
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Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle.
Science. 1996 May 10;272(5263):877-80
PMID: 8629023
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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors.
Cell. 1996 May 31;85(5):707-20
PMID: 8646779
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Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).
Cell. 1996 May 31;85(5):721-32
PMID: 8646780
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A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice.
Cell. 1996 May 31;85(5):733-44
PMID: 8646781
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Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
Nature. 1996 Jul 25;382(6589):325-31
PMID: 8684460
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Novel mutations detected in the TSC2 gene from both sporadic and familial TSC patients.
Hum Mol Genet. 1996 Feb;5(2):249-56
PMID: 8824881
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The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase.
EMBO J. 1996 Oct 1;15(19):5280-9
PMID: 8895573
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Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients.
Nat Med. 1997 Feb;3(2):222-5
PMID: 9018243
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Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer.
Nat Med. 1997 Feb;3(2):227-30
PMID: 9018244
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Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.
Nat Med. 1997 Feb;3(2):231-4
PMID: 9018245
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Aberrant p27kip1 expression in endocrine and other tumors.
Am J Pathol. 1997 Feb;150(2):401-7
PMID: 9033255
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The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2.
Genes Dev. 1997 Feb 15;11(4):492-503
PMID: 9042862
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The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis.
J Biol Chem. 1997 Mar 7;272(10):6097-100
PMID: 9045618
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Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest.
J Biol Chem. 1997 Mar 14;272(11):7093-8
PMID: 9054402
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The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas.
Cancer Res. 1997 Apr 1;57(7):1259-63
PMID: 9102210
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Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.
Nature. 1997 May 22;387(6631):422-6
PMID: 9163430
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Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27(Kip1) binding to newly formed complexes.
Oncogene. 1997 May 22;14(20):2373-81
PMID: 9188852
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Cyclin E-CDK2 is a regulator of p27Kip1.
Genes Dev. 1997 Jun 1;11(11):1464-78
PMID: 9192873
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Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1.
Mol Cell Biol. 1997 Jul;17(7):3850-7
PMID: 9199319
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Cyclin-dependent kinase inhibitor p27KIP1 in lymphoid tissue: p27KIP1 expression is inversely proportional to the proliferative index.
Am J Pathol. 1997 Jul;151(1):151-60
PMID: 9212741
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Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34.
Science. 1997 Aug 8;277(5327):805-8
PMID: 9242607
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Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer.
Cancer Res. 1997 Aug 15;57(16):3381-5
PMID: 9270000
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Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts.
Mol Cell Biol. 1997 Sep;17(9):5348-58
PMID: 9271412
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Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins.
EMBO J. 1997 Sep 1;16(17):5322-33
PMID: 9311992
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Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27.
EMBO J. 1997 Sep 1;16(17):5334-44
PMID: 9311993
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Molecular genetic and phenotypic analysis reveals differences between TSC1 and TSC2 associated familial and sporadic tuberous sclerosis.
Hum Mol Genet. 1997 Nov;6(12):2155-61
PMID: 9328481
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Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase.
J Biol Chem. 1997 Nov 14;272(46):29301-8
PMID: 9361010
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Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes.
Oncogene. 1997 Nov 20;15(21):2561-76
PMID: 9399644
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Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma.
Cancer Res. 1998 Feb 1;58(3):542-8
PMID: 9458103
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Reduced levels of the cell-cycle inhibitor p27Kip1 in epithelial dysplasia and carcinoma of the oral cavity.
Am J Pathol. 1998 Feb;152(2):585-90
PMID: 9466585
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Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma.
Cancer Res. 1998 Apr 15;58(8):1730-5
PMID: 9563491
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Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products.
Hum Mol Genet. 1998 Jun;7(6):1053-7
PMID: 9580671
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Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells.
Oncogene. 1998 May;16(20):2575-83
PMID: 9632134
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Association of p27Kip1 levels with recurrence and survival in patients with stage C prostate carcinoma.
J Natl Cancer Inst. 1998 Jun 17;90(12):916-20
PMID: 9637141
-
Protein expression of the cell-cycle inhibitor p27Kip1 in malignant melanoma: inverse correlation with disease-free survival.
Am J Pathol. 1998 Jul;153(1):305-12
PMID: 9665492
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A novel function of adenovirus E1A is required to overcome growth arrest by the CDK2 inhibitor p27(Kip1).
EMBO J. 1998 Oct 15;17(20):5987-97
PMID: 9774342
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The murine gene p27Kip1 is haplo-insufficient for tumour suppression.
Nature. 1998 Nov 12;396(6707):177-80
PMID: 9823898
-
Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2.
Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15653-8
PMID: 9861025
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Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer.
Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):327-31
PMID: 8419937
-
Identification and characterization of the tuberous sclerosis gene on chromosome 16.
Cell. 1993 Dec 31;75(7):1305-15
PMID: 8269512
-
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
Genes Dev. 1994 Jan;8(1):9-22
PMID: 8288131
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Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients.
Nat Genet. 1994 Feb;6(2):193-6
PMID: 8162074
-
Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity.
J Biol Chem. 1995 Jul 7;270(27):16409-14
PMID: 7608212
-
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21.
Cell. 1994 Jul 15;78(1):67-74
PMID: 8033213
-
Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene.
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11413-6
PMID: 7972075
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Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias.
Cancer Res. 1995 Mar 15;55(6):1206-10
PMID: 7882309
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p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors.
Cancer Res. 1995 Mar 15;55(6):1211-4
PMID: 7882310