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PMID: 985635 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Abnormal or absent beta mRNA in betao Ferrara and gene deletion in delta beta thalassaemia.

Nature ·Vol. 263 ·No. 5577 ·1976-10-07 ·Pages 471-5

Ramirez F, O'Donnell JV, Marks PA, Bank A, Musumeci S, Schilirò G, Pizzarelli G, Russo G, Luppis B, Gambino R

Abstract

In patients with betao thalassaemia from Ferrara, beta globin mRNA sequences are either absent or structurally abnormal while in betao thalassaemia in Catania, beta globin mRNA sequences are present. In deltabeta thalassaemia there is a deletion of beta-like globin genes, while in betao Catania DNA, no beta globin gene deletion is detectable.

MeSH Terms

Child Child, Preschool Chromosome Deletion Genes Humans Nucleic Acid Hybridization RNA, Messenger/analysis,deficiency,metabolism Thalassemia/genetics,metabolism

Chemicals

RNA, Messenger

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Ramirez F

O'Donnell J V

Marks P A

Bank A

Musumeci S

Schilirò G

Pizzarelli G

Russo G

Luppis B

Gambino R

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/263471a0

Published

1976-10-07

Pages

471-5

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/263471a0 View journal details

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Abnormal or absent beta mRNA in betao Ferrara and gene deletion in delta beta thalassaemia.

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