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PMID: 9851926 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Promotion of trophoblast stem cell proliferation by FGF4.

Science (New York, N.Y.) ·Vol. 282 ·No. 5396 ·1998-12-11 ·Pages 2072-5

Tanaka S, Kunath T, Hadjantonakis AK, Nagy A, Rossant J

Abstract

The trophoblast cell lineage is essential for the survival of the mammalian embryo in utero. This lineage is specified before implantation into the uterus and is restricted to form the fetal portion of the placenta. A culture of mouse blastocysts or early postimplantation trophoblasts in the presence of fibroblast growth factor 4 (FGF4) permitted the isolation of permanent trophoblast stem cell lines. These cell lines differentiated to other trophoblast subtypes in vitro in the absence of FGF4 and exclusively contributed to the trophoblast lineage in vivo in chimeras.

MeSH Terms
Animals Blastocyst/cytology Cell Differentiation Cell Division Cell Line Cell Lineage Chimera Culture Media, Conditioned Embryo, Mammalian/cytology Female Fibroblast Growth Factor 4 Fibroblast Growth Factors/pharmacology,physiology Fibroblasts/cytology Gene Expression Regulation, Developmental Genetic Markers Karyotyping Male Mice Models, Biological Proto-Oncogene Proteins/pharmacology,physiology Signal Transduction Stem Cells/cytology,metabolism Trophoblasts/cytology,metabolism
Chemicals
Culture Media, Conditioned Fgf4 protein, mouse Fibroblast Growth Factor 4 Genetic Markers Proto-Oncogene Proteins Fibroblast Growth Factors
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Tanaka S
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Kunath T
Hadjantonakis A K
Nagy A
Rossant J
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.282.5396.2072
Published
1998-12-11
Pages
2072-5
Language
English
Region
United States
NLM ID
0404511
Subset
IM
External Links
PubMed source DOI: 10.1126/science.282.5396.2072 View journal details
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