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PMID: 9847381 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Nuclear magnetic resonance analysis of solution conformations in C4-V3 hybrid peptides derived from human immunodeficiency virus (HIV) type 1 gp120: relation to specificity of peptide-induced anti-HIV neutralizing antibodies.

Journal of virology ·Vol. 73 ·No. 1 ·1999-01-00 ·Pages 746-50

Vu HM, Myers D, de Lorimier R, Matthews TJ, Moody MA, Heinly C, Torres JV, Haynes BF, Spicer L

Abstract

Immunogenic peptides containing epitopes of the gp120 C4 and V3 regions from human immunodeficiency virus strains MN and EV91 have been studied by nuclear magnetic resonance and molecular modeling and used as immunogens in rhesus monkeys. The results, combined with those for other peptides, suggest a correlation between solution conformation and immunologic cross-reactivity.

MeSH Terms
Amino Acid Sequence Animals Cross Reactions HIV Antibodies/biosynthesis HIV Envelope Protein gp120/chemistry,immunology Macaca mulatta Magnetic Resonance Spectroscopy Models, Biological Molecular Sequence Data Protein Conformation Structure-Activity Relationship
Chemicals
HIV Antibodies HIV Envelope Protein gp120
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Vu H M
Departments of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.
Myers D
de Lorimier R
Matthews T J
Moody M A
Heinly C
Torres J V
Haynes B F
Spicer L
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31 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.73.1.746-750.1999
Published
1999-01-00
Pages
746-50
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC103882
Subset
IM
Grants
NIAID NIH HHS · AI07392-06 · United States
NIAID NIH HHS · T32 AI007392 · United States
NIAID NIH HHS · AI135351 · United States
NIGMS NIH HHS · GM 41829 · United States
NIAID NIH HHS · T32 AI007217 · United States
External Links
PubMed source DOI: 10.1128/JVI.73.1.746-750.1999 PMC Full Text View journal details
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