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PMID: 9835538 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Examination of methicillin-resistant and methicillin-susceptible Staphylococcus aureus mutants with low-level fluoroquinolone resistance.

Antimicrobial agents and chemotherapy ·Vol. 42 ·No. 12 ·1998-12-00 ·Pages 3317-9

Sulavik MC, Barg NL

Abstract

For Staphylococcus aureus, stepwise mutations result in high-level quinolone resistance. Methicillin-resistant and -susceptible quinolone-resistant, first-step mutants generated in vitro were obtained and found to be no different than those recovered from murine abscesses. Approximately 10% of all first-step mutants were resistant to ethidium bromide, and selected strains had mutations that mapped to flqB. NorA-mediated resistance among first-step mutants may be more prevalent than previously reported.

MeSH Terms
Animals Anti-Infective Agents/pharmacology Chromosome Mapping DNA, Bacterial/analysis,genetics Drug Resistance, Microbial Fluoroquinolones Genetic Linkage Methicillin/pharmacology Methicillin Resistance Mice Microbial Sensitivity Tests Mutation Penicillins/pharmacology Phenotype Staphylococcus aureus/drug effects,genetics,isolation & purification
Chemicals
Anti-Infective Agents DNA, Bacterial Fluoroquinolones Penicillins Methicillin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sulavik M C
Department of Medicine, Division of Infectious Diseases, University of Michigan Medical School, and Department of Veterans Affairs Medical Center, Ann Arbor, Michigan, USA.
Barg N L
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.42.12.3317
Published
1998-12-00
Pages
3317-9
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC106046
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.42.12.3317 PMC Full Text View journal details
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