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PMID: 9829958 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A family of stability determinants in pathogenic bacteria.

Journal of bacteriology ·Vol. 180 ·No. 23 ·1998-12-00 ·Pages 6415-8

Hayes F

Abstract

A novel segregational stability system was identified on plasmid R485, which originates from Morganella morganii. The system is composed of two overlapping genes, stbD and stbE, which potentially encode proteins of 83 and 93 amino acids, respectively. Homologs of the stbDE genes were identified on the enterotoxigenic plasmid P307 from Escherichia coli and on the chromosomes of Vibrio cholerae and Haemophilus influenzae biogroup aegyptius. The former two homologs also promote plasmid stability in E. coli. Furthermore, the stbDE genes share homology with components of the relBEF operon and with the dnaT gene of E. coli. The organization of the stbDE cassette is reminiscent of toxin-antitoxin stability cassettes.

MeSH Terms
Amino Acid Sequence Bacterial Proteins/genetics Base Sequence Chromosome Mapping DNA, Bacterial/genetics Enterobacteriaceae/genetics,pathogenicity Escherichia coli/genetics Genes, Bacterial Haemophilus influenzae/genetics Molecular Sequence Data Multigene Family Open Reading Frames Plasmids/genetics Sequence Homology, Amino Acid Vibrio cholerae/genetics Virulence/genetics
Chemicals
Bacterial Proteins DNA, Bacterial StbD protein, Morganella morganii StbE protein, Morganella morganii
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hayes F
Microbiology Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, England, UK. Finbarr.hayes@mail.bi.umist.ac.uk
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/JB.180.23.6415-6418.1998
Email
finbarr.hayes@mail.bi.umist.ac.uk
Published
1998-12-00
Pages
6415-8
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC107735
Subset
IM
Grants
Wellcome Trust · United Kingdom
Databases
GENBANK
AF072126
External Links
PubMed source DOI: 10.1128/JB.180.23.6415-6418.1998 PMC Full Text View journal details
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