Recent advances in gene expression using alphavirus vectors.

Current opinion in biotechnology ·Vol. 9 ·No. 5 ·1998-10-00 ·Pages 464-9

Garoff H, Li KJ

Abstract

Alphavirus vectors use RNA replication in the cell cytoplasm to direct gene expression. New developments of vectors put persistency of expression and infection of specific cells in focus. Furthermore, a new application shows that the system can be used for production of retrovirus vectors carrying genes with introns and control/regulatory regions.

MeSH Terms

Alphavirus/genetics Animals Biotechnology Cytopathogenic Effect, Viral DNA, Recombinant/genetics Gene Expression Genetic Vectors Humans RNA/genetics Replicon Retroviridae/genetics

Chemicals

DNA, Recombinant RNA, recombinant RNA

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Garoff H

Department of Biosciences at Novum, Huddinge, Sweden. henrik.garoff@cbt.ki.se

Li K J

Article Info

Journal

Current opinion in biotechnology

Abbr.

Curr Opin Biotechnol

ISSN

0958-1669

DOI

10.1016/s0958-1669(98)80030-x

henrik.garoff@cbt.ki.se

Published

1998-10-00

Pages

464-9

Language

English

Region

England

NLM ID

9100492

Subset

External Links

PubMed source DOI: 10.1016/s0958-1669(98)80030-x View journal details

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