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PMID: 9813779 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Finding specific genes that cause autism: a combination of approaches will be needed to maximize power.

Journal of autism and developmental disorders ·Vol. 28 ·No. 5 ·1998-10-00 ·Pages 439-45

Folstein SE, Bisson E, Santangelo SL, Piven J

Abstract

Although autism is clearly inherited, it may be challenging to find the genes involved: The mechanism of inheritance is unknown, families with an autistic child are usually small, parent-child pairs are rare, and a fairly large number of genes may be involved, some or all of which may have a small effect on the phenotype. We discuss several strategies for finding genes, all of which may be used in combination to find the relevant genes.

MeSH Terms
Autistic Disorder/genetics Family Genetic Linkage Genetic Markers Humans Phenotype Research Design
Chemicals
Genetic Markers
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Folstein S E
Department of Psychiatry, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA.
Bisson E
Santangelo S L
Piven J
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Article Info
Journal
Journal of autism and developmental disorders
Abbr.
J Autism Dev Disord
ISSN
0162-3257
DOI
10.1023/a:1026008606672
Published
1998-10-00
Pages
439-45
Language
English
Region
United States
NLM ID
7904301
Subset
IM
Grants
NIMH NIH HHS · MH 01338 · United States
NIMH NIH HHS · MH 55135 · United States
External Links
PubMed source DOI: 10.1023/a:1026008606672 View journal details
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