Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors.

Genomics ·Vol. 52 ·No. 2 ·1998-09-01 ·Pages 223-9

Tan CP, McKee KK, Liu Q, Palyha OC, Feighner SD, Hreniuk DL, Smith RG, Howard AD

Abstract

Growth hormone secretagogues (GHS) are a group of synthetic peptide and nonpeptide molecules that potently stimulate the release of GH from the anterior pituitary gland through the activation of a novel G-protein-coupled receptor (GPC-R), the GHS-R. In our search for GHS-R family members, we recently described the cloning of two related GPC-Rs, GPR38 and 39. In the present report, we detail the isolation of a new GPC-R (FM-3) from human and mouse with moderate sequence identity to both the GHS-R and neurotensin-R. FM-3 is expressed in a diverse set of tissues.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Cell Line Cloning, Molecular DNA/chemistry,genetics DNA, Complementary/chemistry,genetics GTP-Binding Proteins/metabolism Gene Expression Humans Membrane Proteins Mice Molecular Sequence Data RNA, Messenger/genetics,metabolism Receptors, Cell Surface/genetics,metabolism Receptors, G-Protein-Coupled Receptors, Ghrelin Receptors, Neurotensin/genetics Receptors, Neurotransmitter Sequence Analysis, DNA Sequence Homology, Amino Acid T-Lymphocytes/chemistry,metabolism Tissue Distribution Transfection

Chemicals

DNA, Complementary Membrane Proteins RNA, Messenger Receptors, Cell Surface Receptors, G-Protein-Coupled Receptors, Ghrelin Receptors, Neurotensin Receptors, Neurotransmitter neuromedin U receptor DNA GTP-Binding Proteins

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Tan C P

Department of Biochemistry and Physiology, Merck Research Laboratories, Building RY-80Y-265, Rahway, New Jersey, 07065, USA.

McKee K K

Liu Q

Palyha O C

Feighner S D

Hreniuk D L

Smith R G

Howard A D

Article Info

Journal

Genomics

Abbr.

Genomics

ISSN

0888-7543

DOI

10.1006/geno.1998.5441

Published

1998-09-01

Pages

223-9

Language

English

Region

United States

NLM ID

8800135

Subset

Databases

GENBANK

AF044600, AF044601

External Links

PubMed source DOI: 10.1006/geno.1998.5441 View journal details

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Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors.

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