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PMID: 9781519 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease.

Neurology ·Vol. 51 ·No. 4 ·1998-10-00 ·Pages 993-9

Jack CR, Petersen RC, Xu Y, O'Brien PC, Smith GE, Ivnik RJ, Tangalos EG, Kokmen E

Abstract

To determine the annual rates of volumetric change of the hippocampus and temporal horn in cognitively normal elderly control subjects and individually matched patients with AD, and to test the hypothesis that these rates were different. Cross-sectional studies consistently reveal cerebral atrophy in elderly nondemented subjects compared with healthy young adults, and greater atrophy in patients with AD relative to elderly control subjects. However, rates of atrophy are estimated most accurately by performing serial measurements in the same individuals. MRI-based volumetric measurements of the hippocampi and temporal horns were performed in 24 cognitively normal subjects aged 70 to 89 years who were individually matched with respect to gender and age with 24 patients with AD. Each subject underwent an MRI protocol twice, separated by 12 months or more. The mean annual rate of hippocampal volume loss among control subjects was -1.55+/-1.38% and the temporal horns increased in volume by 6.15+/-7.69% per year. These rates were significantly greater among AD patients: hippocampus, -3.98+/-1.92% per year, p < 0.001; temporal horn, 14.16+/-8.47% per year, p = 0.002. A statistically significant yearly decline in hippocampal volume and an increase in temporal horn volume was identified in elderly control subjects who represent typical aging individuals. These rates were approximately 2.5 times greater in patients with AD than in individually age- and gender-matched control subjects.

MeSH Terms
Aged Aged, 80 and over Aging/pathology Alzheimer Disease/epidemiology,genetics,pathology Apolipoproteins E/genetics Atrophy Comorbidity Diabetes Mellitus, Type 1/epidemiology Female Genotype Hippocampus/pathology Hormone Replacement Therapy Humans Hypertension/epidemiology Male Myocardial Ischemia/epidemiology Prevalence Reproducibility of Results Risk Factors Temporal Lobe/pathology
Chemicals
Apolipoproteins E
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Jack C R
Department of Diagnostic Radiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
Petersen R C
Xu Y
O'Brien P C
Smith G E
Ivnik R J
Tangalos E G
Kokmen E
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Article Info
Journal
Neurology
Abbr.
Neurology
ISSN
0028-3878
DOI
10.1212/wnl.51.4.993
Published
1998-10-00
Pages
993-9
Language
English
Region
United States
NLM ID
0401060
PMCID
PMC2768817
Subset
IM
Grants
NIA NIH HHS · P30 AG008031-099004 · United States
NIA NIH HHS · R01 AG011378 · United States
NIA NIH HHS · AG-06786 · United States
NIA NIH HHS · NIH-NIA-AG11378 · United States
NIA NIH HHS · U01 AG006786-14 · United States
NIA NIH HHS · R01 AG011378-10 · United States
NIA NIH HHS · U01 AG006786 · United States
NIA NIH HHS · AG-08031 · United States
External Links
PubMed source DOI: 10.1212/wnl.51.4.993 PMC Full Text View journal details
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