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PMID: 9770535 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Free recombination within Helicobacter pylori.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 95 ·No. 21 ·1998-10-13 ·Pages 12619-24

Suerbaum S, Smith JM, Bapumia K, Morelli G, Smith NH, Kunstmann E, Dyrek I, Achtman M

Abstract

Sequences of three gene fragments (flaA, flaB, and vacA) from Helicobacter pylori strains isolated from patients in Germany, Canada, and South Africa were analyzed for diversity and for linkage equilibrium by using the Homoplasy Test and compatibility matrices. Horizontal genetic exchange in H. pylori is so frequent that different loci and polymorphisms within each locus are all at linkage equilibrium. These results indicate that H. pylori is panmictic. Comparisons with sequences from Escherichia coli, Neisseria meningitidis, and Drosophila melanogaster showed that recombination in H. pylori was much more frequent than in other species. In contrast, when multiple family members infected with H. pylori were investigated, some strains were indistinguishable at all three loci. Thus, H. pylori is clonal over short time periods after natural transmission.

MeSH Terms
Alleles Bacterial Proteins/genetics Base Sequence DNA Primers Flagellin/genetics Helicobacter pylori/genetics Molecular Sequence Data Phylogeny Recombination, Genetic Species Specificity
Chemicals
Bacterial Proteins DNA Primers VacA protein, Helicobacter pylori Flagellin flaA protein, bacteria flaB flagellin
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Suerbaum S
Department of Medical Microbiology, Ruhr-Universität Bochum, D-44780 Bochum, Germany. suerbaum@ruhr-uni-bochum.de
Smith J M
Bapumia K
Morelli G
Smith N H
Kunstmann E
Dyrek I
Achtman M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.95.21.12619
Email
suerbaum@ruhr-uni-bochum.de
Published
1998-10-13
Pages
12619-24
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC22880
Subset
IM
Grants
Wellcome Trust · United Kingdom
Databases
GENBANK
AJ009170, AJ009171, AJ009172, AJ009173, AJ009174, AJ009175, AJ009176, AJ009177, AJ009178, AJ009179, AJ009180, AJ009181, AJ009182, AJ009183, AJ009184, AJ009185, AJ009186, AJ009187, AJ009188, AJ009189, AJ009190, AJ009191, AJ009192, AJ009193, AJ009194, AJ009195, AJ009196, AJ009197, AJ009198, AJ009199
External Links
PubMed source DOI: 10.1073/pnas.95.21.12619 PMC Full Text View journal details
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