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PMID: 9765578 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Influence of the MexAB-OprM multidrug efflux system on quorum sensing in Pseudomonas aeruginosa.

Journal of bacteriology ·Vol. 180 ·No. 20 ·1998-10-00 ·Pages 5443-7

Evans K, Passador L, Srikumar R, Tsang E, Nezezon J, Poole K

Abstract

Pseudomonas aeruginosa nalB mutants which hyperexpress the MexAB-OprM multidrug efflux system produce reduced levels of several extracellular virulence factors known to be regulated by quorum sensing. Such mutants also produce less acylated homoserine lactone autoinducer PAI-1, consistent with an observed reduction in lasI expression. These data suggest that PAI-1 is a substrate for MexAB-OprM, and its resulting exclusion from cells hyperexpressing MexAB-OprM limits PAI-1-dependent activation of lasI and the virulence genes.

MeSH Terms
4-Butyrolactone/analogs & derivatives,biosynthesis Bacterial Proteins/biosynthesis,metabolism Biological Transport Drug Resistance, Multiple/genetics Gene Expression Regulation, Bacterial Pheromones/biosynthesis Pseudomonas aeruginosa/pathogenicity,physiology Pyocyanine/biosynthesis Signal Transduction/genetics Virulence/genetics
Chemicals
Bacterial Proteins LasI protein, Pseudomonas aeruginosa Pheromones N-(3-oxohexanoyl)-3-aminodihydro-2(3H)-furanone Pyocyanine 4-Butyrolactone
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Evans K
Department of Microbiology and Immunology, Queen's University, Kingston, Ontario K7L 3N6, Canada.
Passador L
Srikumar R
Tsang E
Nezezon J
Poole K
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/JB.180.20.5443-5447.1998
Published
1998-10-00
Pages
5443-7
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC107595
Subset
IM
External Links
PubMed source DOI: 10.1128/JB.180.20.5443-5447.1998 PMC Full Text View journal details
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