The role of adhesion molecules in allergic inflammation and their suitability as targets of antiallergic therapy.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology ·Vol. 28 Suppl 3 ·1998-08-00 ·Pages 15-23

Schleimer RP, Bochner BS

Abstract

Adhesion molecules on leukocytes and tissue-resident cells are now known to mediate steps of the allergic inflammation response. Blockade of adhesion pathways is being actively explored as a potential strategy to therapeutically manage allergic diseases. The various adhesion molecules and their counterligands are discussed with respect to evidence supporting their role in allergic inflammation and suitability as therapeutic targets.

MeSH Terms

Animals Antibodies, Monoclonal/pharmacology Antigens, CD/immunology Asthma/immunology Cell Adhesion Molecules/drug effects,immunology Guinea Pigs Haplorhini Humans Hypersensitivity/immunology,therapy Integrins/analysis,immunology Intercellular Adhesion Molecule-1/immunology Leukocyte-Adhesion Deficiency Syndrome/immunology Mice Mice, Knockout Phenotype Platelet Endothelial Cell Adhesion Molecule-1/immunology Rabbits Rats Selectins/analysis,immunology Sheep

Chemicals

Antibodies, Monoclonal Antigens, CD Cell Adhesion Molecules ICAM2 protein, human Integrins Platelet Endothelial Cell Adhesion Molecule-1 Selectins Intercellular Adhesion Molecule-1

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Schleimer R P

Johns Hopkins University School of Medicine at the Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224-6801, USA.

Bochner B S

Article Info

Journal

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Abbr.

Clin Exp Allergy

ISSN

0954-7894

Published

1998-08-00

Pages

15-23

Language

English

Region

England

NLM ID

8906443

Subset

External Links

PubMed source View journal details

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The role of adhesion molecules in allergic inflammation and their suitability as targets of antiallergic therapy.

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