| GeneLibs

题目:: Identification of germ-line E-cadherin mutations in gastric cancer families of European origin.
作者:: Gayther(S A),Gorringe(K L),Ramus(S J),Huntsman(D),Roviello(F),Grehan(N),Machado(J C),Pinto(E),Seruca(R),Halling(K),MacLeod(P),Powell(S M),Jackson(C E),Ponder(B A),Caldas(C)
状态:: 发布时间1998-10-01 , 更新时间 2006-11-15
期刊:: Cancer Res
摘要:: E-cadherin germ-line mutations have recently been described as a molecular basis for early-onset familial gastric cancer in Maori kindred. We screened 18 gastric cancer families of European origin for germ-line mutations to determine the proportion in which E-cadherin mutations occur and the clinical characteristics of the affected families. Truncating mutations were identified in three kindred with familial diffuse gastric cancer. In these families, the age of onset of gastric cancer was variable, the penetrance was incomplete, and one kindred contained individuals with cancers at other sites. Here, we show that a proportion of diffuse gastric cancer families of European origin have germ-line E-cadherin mutations; however, these mutations are absent in intestinal gastric cancer families.
语言:: eng
DOI:

文献库文献相关信息