Cell cycle: oiling the gears of anaphase.

Current biology : CB ·Vol. 8 ·No. 18 ·1998-09-10 ·Pages R636-9

Wolf DA, Jackson PK

Abstract

The anaphase-promoting complex (APC) or cyclosome directs the ubiquitination and destruction of proteins that control specific steps in mitosis. Recent studies show that APC activity requires WD40 domain proteins, and that one of these proteins is part of the checkpoint control that ensures accurate chromosome segregation.

MeSH Terms

Anaphase/physiology Anaphase-Promoting Complex-Cyclosome Animals Cell Cycle/physiology Cyclic AMP-Dependent Protein Kinases Cyclin-Dependent Kinases/metabolism Fungal Proteins/physiology Ligases/physiology Mitosis Models, Biological Proteins/metabolism Ubiquitin-Protein Ligase Complexes Ubiquitin-Protein Ligases Ubiquitins/metabolism

Chemicals

Fungal Proteins Proteins Ubiquitins Ubiquitin-Protein Ligase Complexes Anaphase-Promoting Complex-Cyclosome Ubiquitin-Protein Ligases Cyclic AMP-Dependent Protein Kinases Cyclin-Dependent Kinases Ligases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wolf D A

Department of Pathology, Stanford University School of Medicine, Palo Alto, California 94305, USA.

Jackson P K

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(07)00410-1

Published

1998-09-10

Pages

R636-9

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(07)00410-1 View journal details

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