The effect of low-dose pre-operative X-irradiation of implanted mouse mammary carcinomas on local recurrence and metastasis.

British journal of cancer ·Vol. 34 ·No. 4 ·1976-10-00 ·Pages 401-7

Sheldon PW, Fowler JF

Abstract

Pre-operative X-irradiation of s.c. implanted first-generation mammary tumours in C3H mice, using either 500 rad or two fractions of 350 rad, produced no improvement in the success of surgery in causing local control or in reduction of distant metastases. The metastasis rate was just significantly higher after the two-fraction treatment of the implanted tumour than after surgical removal alone. The results are in agreement with previously published results on carcinomas and a sarcoma but contrast with those for murine lymphomas.

MeSH Terms

Animals Lung Neoplasms Male Mammary Neoplasms, Experimental/radiotherapy,surgery Mice Mice, Inbred C3H Neoplasm Metastasis Neoplasm Recurrence, Local Radiotherapy Dosage

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Sheldon P W

Fowler J F

References (13)

13 references, click to expand

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Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1038/bjc.1976.183

Published

1976-10-00

Pages

401-7

Language

English

Region

England

NLM ID

0370635

PMCID

PMC2025262

Subset

External Links

PubMed source DOI: 10.1038/bjc.1976.183 PMC Full Text View journal details

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The effect of low-dose pre-operative X-irradiation of implanted mouse mammary carcinomas on local recurrence and metastasis.

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